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The Human Upgrade: Biohacking for Longevity & Performance podcast

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The Human Upgrade: Biohacking for Longevity & Performance

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  Dave Asprey  

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

 

All

Progress

Duration

Release Date

#1543

It's Weird, But It Turns On Your Body's Anti-Aging Switch Fast : 1487

Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/ Tr... more

Yesterday

15 MINS

15:34

Yesterday

#1542

Sugar-Free Backlash, Taurine Fail, Copper Brain Therapy, Childhood Biohacking, Strength Training : 1...

Sugar-Free Diets Disrupted Gut Microbiome and Metabolism A 16-week sucrose-free, low-fat d... more

19 Jun 2026

11 MINS

11:33

19 Jun 2026

#1541

BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin : 1486

Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most p... more

18 Jun 2026

1 HR 01 MINS

1:01:02

18 Jun 2026

#1540

The Skin Mistakes That Age You Fast and Kill You Slow | Dr. Michael Christopher : 1485

Skin Cancer Prevention, Anti-Aging Biohacking, and the Melanoma Detection Gap Mostdermatol... more

16 Jun 2026

44 MINS

44:40

16 Jun 2026

#1539

Just 1 Gram Activates Your Deep Focus Switch (Take THIS) : 1484

Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/ Tr... more

14 Jun 2026

11 MINS

11:53

14 Jun 2026

#1538

World Cup, Sunscreen, Hair Regrowth, Caffeine Chewing Gum, and more... : 1483

Semaglutide Slows Biological Aging A randomized, placebo-controlled study published in Nat... more

12 Jun 2026

11 MINS

11:03

12 Jun 2026

#1537

Brain Fog, Memory Loss, and Alzheimer's Prevention | Dr. Majid Fotuhi : 1482

How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzhe... more

11 Jun 2026

1 HR 19 MINS

1:19:53

11 Jun 2026

#1536

The Foods That Starve Cancer | William Li : 1481

Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health Your ... more

09 Jun 2026

1 HR 03 MINS

1:03:09

09 Jun 2026

#1535

I Drink Fat To Look Shredded (Lost 100lbs) : 1480

I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90... more

07 Jun 2026

07 MINS

07:35

07 Jun 2026

#1534

Putin Longevity, Pancreatic Cancer Cure, AI Therapy, GLP-1 Breast Cancer... : 1479

Pancreatic Cancer Halted by Virus Injection Researchers injected an engineered virus direc... more

05 Jun 2026

10 MINS

10:06

05 Jun 2026

#1533

How to Get Microplastics Out of Your Body | Mara Labs : 1478

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal Microplastics arebui... more

04 Jun 2026

1 HR 01 MINS

1:01:21

04 Jun 2026

#1532

Peptide Power Without Needles: Smarter Dosing for Longevity | Justin Kirkland : 1477

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Pat... more

02 Jun 2026

54 MINS

54:44

02 Jun 2026

#1531

Brain Fog Starts in Your Feet (Scientifically Proven) : 1476

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily,... more

31 May 2026

08 MINS

08:26

31 May 2026

#1530

NASCAR Death, Steroid Olympics, Genetic Age Truth, and Gut Depression... : 1475

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" Th... more

29 May 2026

08 MINS

08:38

29 May 2026

#1529

Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD... more

28 May 2026

1 HR 23 MINS

1:23:33

28 May 2026

#1528

The Doctor With Answers To Your Mystery Symptoms | Jessica Peatross : 1473

The Hidden Causes of Brain Fog, Anxiety, and Chronic Illness: Mold, Parasites, Histamine, ... more

26 May 2026

1 HR 16 MINS

1:16:51

26 May 2026

#1527

The EXACT Japanese Formula To Live Past 100+ (Simple Steps) : 1471

In this video, I break down the exact biological mechanisms keeping men in Okinawa, Japan,... more

24 May 2026

09 MINS

09:32

24 May 2026

#1526

This Epic Device Gives You A SUPERBRAIN : 1472

Light Therapy, 40Hz Gamma & Brainwave Entrainment: HowBrainTapResets Sleep, Clears Brain F... more

22 May 2026

15 MINS

15:00

22 May 2026

#1525

The Biblical Anti-Aging Fruit That Scientists Are Obsessed With : 1470

The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals ca... more

21 May 2026

53 MINS

53:06

21 May 2026

#1524

How To Hack Your Brain's Missing Youth Molecule | Molly Maloof : 1469

Your relationships are reshaping your biology in ways that diet and exercise alone cannot ... more

19 May 2026

50 MINS

50:39

19 May 2026

#1523

The 4,000-Year-Old Asian Focus Drug That Is Not A Drug : 1468

Most guys over 40 rely on coffee just to survive the day, completely unaware that they are... more

17 May 2026

13 MINS

13:54

17 May 2026

#1522

Semen Switch, Chewing Gum, Creatine Cheat, Cancer Plants, and Bedtime Risk : 1467

One Creatine Dose Kept Sleep-Deprived Brains 12% Sharper A randomized, double-blind crosso... more

15 May 2026

10 MINS

10:50

15 May 2026

#1521

Stop Wasting Your Gym Sweat (40 Minutes of This Wins Every Time) | Will Harlow : 1466

Ifyou'reover 50 and still doing cardio to stay healthy,you'rewasting your time and mayactu... more

14 May 2026

1 HR 04 MINS

1:04:33

14 May 2026