No Priors: Artificial Intelligence | Technology | Startups podcast

No Priors: Artificial Intelligence | Technology | Startups

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.

 

#156

AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus

What happens when you apply the scaling laws of large language models to the physical work... more

03 Apr 2026

29 MINS

29:25

03 Apr 2026


#155

Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI

What happens when AI agents can design experiments, collect data, and improve — without a ... more

20 Mar 2026

1 HR 06 MINS

1:06:31

20 Mar 2026


#154

From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last

Notion isn’t designing AI agents that just use tools. Their agents can autonomously build ... more

12 Mar 2026

29 MINS

29:02

12 Mar 2026


#153

How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil ...

By the end of 2026, AI capital expenditure is projected to hit nearly $700 billion. The qu... more

26 Feb 2026

36 MINS

36:04

26 Feb 2026


#152

From SaaS to AI-First: How Companies Are Reshaping Innovation

In this episode of No Priors, Sarah and Elad dive into the evolving landscape of software,... more

19 Feb 2026

40 MINS

40:41

19 Feb 2026


#151

Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe

Autonomous vehicle technology has moved past human-coded rules and into an era of neural n... more

12 Feb 2026

31 MINS

31:46

12 Feb 2026


#150

Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Ba...

From “virtual doppelgängers” to “real-time dreaming,” online gaming platform Roblox is usi... more

05 Feb 2026

43 MINS

43:44

05 Feb 2026


#149

Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming

What if we could pause biological time to wait for a cure for a disease? Thanks to innovat... more

29 Jan 2026

30 MINS

30:47

29 Jan 2026


#148

No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai

Why are there only a handful of companies in the world with over $10 billion in pure-play ... more

22 Jan 2026

36 MINS

36:37

22 Jan 2026


#147

AI and the Future of Warfare with US Under Secretary of War Emil Michael

Today’s arms race looks a little different from those of the past. Under the Trump adminis... more

15 Jan 2026

44 MINS

44:30

15 Jan 2026


#146

NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative

Even if ChatGPT never existed, the tech giant NVIDIA would still be winning. The end of Mo... more

08 Jan 2026

1 HR 16 MINS

1:16:20

08 Jan 2026


#145

The 2026 AI Forecast: Foundation Models, IPOs, and Robotics with Sarah Guo and Elad Gil

Pundits are screaming about the so-called “AI bubble.” But historically slow-to-adopt indu... more

19 Dec 2025

40 MINS

40:46

19 Dec 2025


#144

The Future of Voice AI: Agents, Dubbing, and Real-Time Translation with ElevenLabs Co-Founder Mati S...

Imagine learning chess from a grand master, or negotiating tactics from an expert FBI host... more

11 Dec 2025

41 MINS

41:37

11 Dec 2025


#143

Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pe...

In just over three years, Harvey has not only scaled to nearly one thousand customers, inc... more

05 Dec 2025

44 MINS

44:17

05 Dec 2025


#142

Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng Chi

The robotics industry is on the cusp of its own “GPT” moment, catalyzed by transformative ... more

19 Nov 2025

39 MINS

39:10

19 Nov 2025


#141

How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara

Bringing new drugs to market is a costly, time-consuming endeavor. On top of that, most me... more

13 Nov 2025

48 MINS

48:13

13 Nov 2025