What happens when AI agents can design experiments, collect data, and improve — without a human in the loop? Andrej Karpathy joins Sarah Guo on the state of models, the future of engineering and education, thinking about impact on jobs, and his project AutoResearch: where agents close the loop on a piece of AI research (experimentation, training, and optimization, autonomously).

00:00 Andrej Karpathy Introduction
02:55 What Capability Limits Remain?
06:15 What Mastery of Coding Agents Looks Like
11:16 Second Order Effects of Natural Language Coding
15:51 Why AutoResearch 
22:45 Relevant Skills in the AI Era
28:25 Model Speciation
32:30 Building More Collaboration Surfaces for Humans and AI
37:28 Analysis of Jobs Market Data
48:25 Open vs. Closed Source Models
53:51 Autonomous Robotics
1:00:59 MicroGPT and Agentic Education
1:05:40 Conclusion

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Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI

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