Talk Python To Me podcast

Talk Python To Me

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.

 

#544

#545: OWASP Top 10 (2025 List) for Python Devs

The OWASP Top 10 just got a fresh update, and there are some big changes: supply chain att... more

16 Apr 2026

1 HR 06 MINS

1:06:03

16 Apr 2026


#543

#544: Wheel Next + Packaging PEPs

When you pip install a package with compiled code, the wheel you get is built for CPU feat... more

10 Apr 2026

1 HR 11 MINS

1:11:17

10 Apr 2026


#542

#543: Deep Agents: LangChain's SDK for Agents That Plan and Delegate

When you type a question into ChatGPT, the model only has what you typed to work with. But... more

01 Apr 2026

1 HR 03 MINS

1:03:53

01 Apr 2026


#541

#542: Zensical - a modern static site generator

If you've built documentation in the Python ecosystem, chances are you've used Martin Dona... more

25 Mar 2026

1 HR 04 MINS

1:04:03

25 Mar 2026


#540

#541: Monty - Python in Rust for AI

When LLMs write code to accomplish a task, that code has to actually run somewhere. And ri... more

19 Mar 2026

1 HR 05 MINS

1:05:44

19 Mar 2026


#539

#540: Modern Python monorepo with uv and prek

Monorepos -- you've heard the talks, you've read the blog posts, maybe you've seen a few t... more

13 Mar 2026

1 HR 02 MINS

1:02:13

13 Mar 2026


#538

#539: Catching up with the Python Typing Council

You're adding type hints to your Python code, your editor is happy, autocomplete is workin... more

06 Mar 2026

1 HR 01 MINS

1:01:41

06 Mar 2026


#537

#538: Python in Digital Humanities

Digital humanities sounds niche, until you realize it can mean a searchable archive of U.S... more

28 Feb 2026

1 HR 12 MINS

1:12:27

28 Feb 2026


#536

#537: Datastar: Modern web dev, simplified

You love building web apps with Python, and HTMX got you excited about the hypermedia appr... more

21 Feb 2026

1 HR 16 MINS

1:16:37

21 Feb 2026


#535

#536: Fly inside FastAPI Cloud

You've built your FastAPI app, it's running great locally, and now you want to share it wi... more

10 Feb 2026

1 HR 07 MINS

1:07:00

10 Feb 2026


#534

#535: PyView: Real-time Python Web Apps

Building on the web is like working with the perfect clay. It’s malleable and can become a... more

23 Jan 2026

1 HR 07 MINS

1:07:56

23 Jan 2026


#533

#534: diskcache: Your secret Python perf weapon

Your cloud SSD is sitting there, bored, and it would like a job. Today we’re putting it to... more

13 Jan 2026

1 HR 14 MINS

1:14:00

13 Jan 2026


#532

#533: Web Frameworks in Prod by Their Creators

Today on Talk Python, the creators behind FastAPI, Flask, Django, Quart, and Litestar get ... more

05 Jan 2026

1 HR 01 MINS

1:01:58

05 Jan 2026


#531

#532: 2025 Python Year in Review

Python in 2025 is in a delightfully refreshing place: the GIL's days are numbered, packagi... more

29 Dec 2025

1 HR 18 MINS

1:18:32

29 Dec 2025


#530

#531: Talk Python in Production

Have you ever thought about getting your small product into production, but are worried ab... more

18 Dec 2025

1 HR 21 MINS

1:21:13

18 Dec 2025


#529

#530: anywidget: Jupyter Widgets made easy

For years, building interactive widgets in Python notebooks meant wrestling with toolchain... more

13 Dec 2025

1 HR 11 MINS

1:11:21

13 Dec 2025


#528

#529: Computer Science from Scratch

A lot of people building software today never took the traditional CS path. They arrived t... more

03 Dec 2025

1 HR 17 MINS

1:17:00

03 Dec 2025


#527

#528: Python apps with LLM building blocks

In this episode, I’m talking with Vincent Warmerdam about treating LLMs as just another AP... more

30 Nov 2025

1 HR 16 MINS

1:16:46

30 Nov 2025


#526

#527: MCP Servers for Python Devs

Today we’re digging into the Model Context Protocol, or MCP. Think LSP for AI: build a sma... more

10 Nov 2025

1 HR 06 MINS

1:06:25

10 Nov 2025


#525

#526: Building Data Science with Foundation LLM Models

Today, we’re talking about building real AI products with foundation models. Not toy demos... more

01 Nov 2025

1 HR 07 MINS

1:07:24

01 Nov 2025


#524

#525: NiceGUI Goes 3.0

Building a UI in Python usually means choosing between "quick and limited" or "powerful an... more

27 Oct 2025

1 HR 17 MINS

1:17:46

27 Oct 2025


#523

#524: 38 things Python developers should learn in 2025

See the full show notes for this episode on the website at [talkpython.fm/524] (https://ta... more

20 Oct 2025

1 HR 09 MINS

1:09:15

20 Oct 2025


#522

#523: Pyrefly: Fast, IDE-friendly typing for Python

See the full show notes for this episode on the website at [talkpython.fm/523] (https://ta... more

13 Oct 2025

1 HR 07 MINS

1:07:00

13 Oct 2025


#521

#522: Data Sci Tips and Tricks from CodeCut.ai

See the full show notes for this episode on the website at [talkpython.fm/522] (https://ta... more

06 Oct 2025

1 HR 09 MINS

1:09:32

06 Oct 2025