This episode of Brain Science features the return of molecular biologist <a title="faculty page" href= "https://www.ed.ac.uk/profile/professor-seth-grant" target="_blank" rel="noopener">Seth Grant</a>. We briefly review his decades of research into the complexity of the protein structure of the synapse and then we focus on his most recent paper, which describes how the life-span of synapse proteins appears to change as animals age. Grant reflects of the significance of this finding both for animal research and human medicine.
Papers discussed in this episode:
---Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker, D. G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A., Merino-Serrais, P., Husi, E., Mendive-Tapia, L., Vendrell, M., O'Dell, T. J., DeFelipe, J., Komiyama, N. H., Holtmaat, A., Fransén, E., & Grant, S. G. N. (2022). A brain atlas of synapse protein lifetime across the mouse lifespan. Neuron, 110(24), 4057–4073.e8. <a href= "https://doi.org/10.1016/j.neuron.2022.09.009">https://doi.org/10.1016/j.neuron.2022.09.009</a>
---Cizeron, M., Qiu, Z., Koniaris, B., Gokhale, R., Komiyama, N. H., Fransén, E., & Grant, S. G. N. (2020). A brainwide atlas of synapses across the mouse life span. Science (New York, N.Y.), 369(6501), 270–275. <a href= "https://doi.org/10.1126/science.aba3163">https://doi.org/10.1126/science.aba3163</a>
Seth Grant has previously appeared on Brain Science several times including <a href= "https://brainsciencepodcast.com/bsp/surprising-discoveries-about-synapse-evolution-with-seth-gra.html" target="_blank" rel="noopener">BSP 51</a>, <a href= "https://brainsciencepodcast.com/bsp/2013/synapse-evolution-with-seth-grant-bsp-101" target="_blank" rel="noopener">BSP 101</a>, <a href= "http://brainsciencepodcast.com/bsp/137-seth-grant" target="_blank" rel="noopener">BS 137</a>, <a href= "http://brainsciencepodcast.com/bsp/2018/150-grant-synaptome" target="_blank" rel="noopener">BSP 150</a> and <a href= "https://brainsciencepodcast.com/bsp/2020/seth-grant-talks-about-synapse-complexity-bs-176" target="_blank" rel="noopener">BS 176</a>.
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