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a16z Podcast podcast

a16z Podcast

The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

 

#250

Crypto Security and the New Web3 Mindsets for Users

Today’s episode is all about crypto security — that is, the new mindsets and the new strategies for storing crypto assets safely while also allowing holders control and access. As a reminder, none of the following should be taken as investment advice, please see a16z.com/disclosures for more important information. We’ve covered security trends more broadly a ton in our content, which you can find at a16z.com/security, as well as crypto-related trends including NFTs, and the creator and ownership economies; you can find all of that at a16z.com/nfts But as more people enter crypto lately — thanks to the boom in NFTs, decentralized finance, and much more — we share specific best practices and options for securing crypto as well as discussing how it all fits this next evolution of the internet: web3. Our expert today is a16z crypto data scientist Eddy Lazzarin, who joins host Zoran Basich to cover practical approaches ranging from passwords to crypto wallets and what users can do; the evolution of crypto briefly; and the big picture mindset shifts involved here as well. We quickly begin with the practical shift crypto security represents compared to how people interact with traditional financial institutions, and then we go into the big picture trends in security when it comes to abstraction and usability. ... Read more

15 Oct 2021

31 MINS

31:09

15 Oct 2021


#249

Cloud Wars and Company Wars: Play Nice But Win

There are lots of challenges in being public while trying to innovate, and limits to being a private company as well; but it's rare to see a company go public then private then back to public again. As is the case with Dell Technologies, one of the largest tech companies -- which went private 2012-2013 and then also pulled off one of the most epic mergers of all time with Dell + EMC + VMWare 2015-2016 (and which we wrote about [here] (https://a16z.com/2015/10/26/dell-emc-vmware/) at the time). Is there a method to the madness? How does one not just start, but keep, and transform, their company and business? Especially as it adapts to broader, underlying tech platform shifts. Michael Dell shares all this in his upcoming new book, Play Nice to Win: A CEO's Journey from Founder to Leader... he also, tellingly, may be one of the longest-standing founder-CEOs (37 years so far). Because this is really a story about innovation, who decides, who judges, who does it, and where: In the markets, in public, in private; in the both the big picture and the inner detailed workings of a business beyond "cells in a spreadsheet"; and even in fighting -- or harnessing! -- narratives, whether it's the demise-of-PC or cloud wars 1.0 /2.0... And where trends like the [cost paradox of cloud] (https://a16z.com/2021/05/27/cost-of-cloud-paradox-market-cap-cloud-lifecycle-scale-growth-repatriation-optimization/) , and " [end of cloud] (https://a16z.com/2019/11/15/the-end-of-cloud-computing-2/) " edge computing, among others like AI & ML, also come in. In this special [book-launch] (https://a16z.com/tag/book-launches/) episode of the a16z Podcast with Marc Andreessen, Martin Casado, and Sonal Chokshi debate the Cloud Wars to the Company Wars (along with some behind-scenes stories and even some star wars) with Michael Dell... and whether you can really play nice to win.   image: [Dell EMC World 2016] (https://www.flickr.com/photos/dellphotos/30312975412/) / © Dell Inc.   The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information. ... Read more

02 Oct 2021

52 MINS

52:57

02 Oct 2021


#248

Uncontrolled Spread: Science, Policy, Institutions, Infrastructure

There's no question technology played a huge role in the recent/current pandemic, including especially in the [plug-and-play] (https://a16z.com/2020/08/14/vaccines-vaccinology-renaissance-covid-pandemic-beyond/) engineering and incredibly fast development [behind] (https://future.a16z.com/podcasts/moderna-covid-vaccine-mrna-technology/) the mRNA vaccines... But is there an even bigger role for the private sector, not just government, to play (and partner) when it comes to key infrastructure for future such emergencies, and even beyond? Especially given how faulty the translation of institutional science to policy and public health measures turned out to be -- for instance, with "6 feet" of social distancing, or with fomite (vs. aerosol) transmission of COVID. And why are we still talking about the same, not specific, vaccine booster for the Delta variant? What can we learn about real-world evidence, other clinical trial approaches, and progressive (vs. binary) EUA approvals when it comes to public health emergencies? Are capabilities like genomic surveillance and mapping strains -- which require layers of technology, real time -- sitting in the right places? In this special [book-launch] (https://a16z.com/tag/book-launches/) episode of the a16z Podcast, former FDA commissioner Dr. Scott Gottlieb -- author of the upcoming [new book] (https://www.harpercollins.com/products/uncontrolled-spread-scott-gottlieb) , Uncontrolled Spread: Why COVID-19 Crushed Us, and How We Can Defeat the Next Pandemic -- shares insights on the above, and revealing stories from behind the scenes. Do we need a new entity to manage public health through a national security lens, and is the government capable? Gottlieb debates this and other probing questions from a16z co-founder Marc Andreessen (who famously wrote " [It's time to build] (https://a16z.com/2020/04/18/its-time-to-build/) "); a16z bio general partner Vineeta Agarwala MD, Phd (who has spoken about [the trials of clinical trials] (https://a16z.com/2021/05/18/bio-eats-world-the-trials-of-clinical-trials/) , practiced medicine during the pandemic, and more); and founding a16z bio general partner Vijay Pande PhD (who, among other things, founded the distributed computing project [Folding@Home ] (https://a16z.com/2020/06/14/folding-at-home-supercomputer-protein-dynamics/) which pivoted to COVID proteins). One thing's for sure -- with this COVID crisis, we're at an inflection point between old and new technology -- whether it's in how we make vaccines, or how we apply the fields of synthetic biology and genetic epidemiology in public health response. So now's the time to look both backward, and forward, to really change things... ... Read more

20 Sep 2021

56 MINS

56:17

20 Sep 2021


#247

Systems Leadership for Disruptors and Incumbents

There's been a false dichotomy in technology and management lore over the past decade, between "brain" and "brawn", digital and physical, independence and interdependence, software culture versus industrial culture… or so observes Stanford Graduate School of Business lecturer, former big-company executive, and startup founder Robert Siegel in his [new book] (https://www.gsb.stanford.edu/faculty-research/books/brains-brawn-company-how-leading-organizations-blend-best-digital-physical) , The Brains and Brawn Company: How leading organizations blend the best of digital and physical. Whether you're an early startup or a Fortune 500 company, we live in an increasingly complex world -- which means embracing digitization is not enough. But logistics, supply chains, and infrastructure are messy, ugly, and hard. So today's leaders have to think completely differently, in terms of ecosystems; and they're often in the position of having to influence but not have control. So when and how do they assert power in an ecosystem? When do they try to shape it? When do they sit back? What to do if their channel partner suddenly changes? When do you want to stay frenemies and when do you wanna be enemies? These are just some of the hard questions companies today have to wrestle with... All boiling down to when and where to partner, when to go it alone? So in this hallway-style discussion among Siegel and fellow Stanford b-school lecturers Jeffrey Immelt (former CEO of GE) and a16z general partner Jeff Jordan -- in conversation with host Sonal Chokshi -- the group wrestles with these questions, spinning through several different company examples such as Instacart and Stripe to Apple and Android/Google to Disney, Peloton, and others. But we talk too much about the outliers; we need to also talk more about the tools, and mindsets, that leaders of all kinds -- not just the once-in-a-generation leaders! -- can use. After all, argues Siegel, "Incumbents are not doomed and disruptors are not ordained."   The views expressed here are those of the AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.   ... Read more

24 Jul 2021

48 MINS

48:01

24 Jul 2021


#246

NFT Use Cases, Today and Tomorrow

Recently, a16z and the [Stanford Center for Blockchain Research] (https://cbr.stanford.edu/) hosted the NFT Virtual Summit, which brought together leading thinkers and builders on the topic of NFTs, or non-fungible tokens — these tokens are enabling new creator and ownership economies to emerge. We’ve covered NFTs in [other podcasts and articles] (https://a16z.com/tag/nfts/) , including a curated list of reading resources, and you can watch [all the videos] (https://a16z.com/2021/05/18/nft-virtual-summit-by-a16z-and-stanford-the-videos/) from the summit.  Today we’re sharing one of the discussions from that virtual summit (all of which were also published on our [a16z Live] (https://a16z.com/a16z-live/) feed) — this episode features General Partner Katie Haun chatting with Devin Finzer, cofounder of NFT marketplace [OpenSea] (https://opensea.io/) , on the topic of NFT “Use Cases, Today, and Tomorrow” — they cover the "tokenization of everything." ### The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information. ... Read more

19 May 2021

19 MINS

19:07

19 May 2021


#245

Man, Mosquito, Malaria Vaccine

Playing out against the backdrop of a global pandemic (including recent massive surges in regions around the world) is the [news that came out] (https://www.ox.ac.uk/news/2021-04-23-malaria-vaccine-becomes-first-achieve-who-specified-75-efficacy-goal) a week ago that a candidate "malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal”. While the findings are still in [preprint] (https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3830681) with The Lancet, the resulting buzz and phrases quoted included everything from “unprecedented”, “groundbreaking work”, and “very exciting” to “high expectations”, “highly effective”, and “a hugely significant extra weapon”... A "weapon" in the war against malaria that is -- a disease that is estimated to cause over 400,000 deaths each year globally, and predominantly in children under the age of five. So in this special 2x explainer episode of 16 Minutes (also running on the a16z Podcast), we -- [Rajeev Venkayya] (https://www.takeda.com/who-we-are/company-information/executive-leadership/rajeev-venkayya/) of Takeda Pharmaceuticals, a16z bio general partner Jorge Conde, and Sonal Chokshi -- dig into what's hype/ what's real about this news, beyond the headlines and beyond the buzz. What does the data tell us, what does the current study phase mean, and [what's left] (https://www.nature.com/articles/d41586-021-01096-7) to get to widespread, real-world use? How does this candidate vaccine (R21 from Jenner Institute/ Oxford University) compare to the other malaria vaccine (RTS,S from GlaxoSmithKline)? How do, and don't, advances in and around COVID vaccines play here? And why has it been so hard to develop vaccines for this particular disease? Because we also cover (as is the premise of the show) where we are on the long arc of innovation... and this is an innovation story that's been [nearly a century] (https://academic.oup.com/cid/article/60/6/930/497479) in the making.  ... Read more

02 May 2021

36 MINS

36:20

02 May 2021


#244

Crypto, an Oral Essay

This is a special episode of the a16z podcast — it's an audio history, told through the voices of the a16z crypto team, about what crypto is, how it really works, and why it matters. This "innovation overview" is meant as a resource, and it features hallway-style conversations with the a16z team as well as outside experts. In brief segments, we’ll take you from the ground up — from the basics, to the most current developments, and beyond that to a look at what we might see in the future.  Here are the topics and voices you'll hear: The Beginning ---Introduction — Zoran Basich, a16z crypto editor ---Before bitcoin: previous attempts to create digital money, 1:45 — Dan Boneh, computer science professor at Stanford and a16 advisor  ---The core innovations of Satoshi’s white paper, 3:36 — Dan Boneh  ---Proof of work, 5:36 — Alex Pruden, chief strategy officer at Aleo Systems and former a16z crypto partner  ---Mining and why it’s important, 7:10 — Alex Pruden  ---The history of mining, 8:20 — Alex Pruden  ---Value in monetary systems, or why bitcoin is worth anything, 9:53 — Arianna Simpson, a16z crypto partner  ---Bitcoin as store of value, 11:30 — Arianna Simpson  ---Security in crypto, 12:45 — Alex Pruden  Expansion ---Why is it called a blockchain? 14:00 — Eddy Lazzarin, a16z data scientist  ---Why the blockchain matters and what you can do with it, 15:09 — Chris Dixon, a16z general partner  ---Beyond bitcoin, 17:01 — Eddy Lazzarin  ---Ethereum as logical extension of open source, 17:36 — Eddy Lazzarin  ---Tokens: What are they? 19:04 — Eddy Lazzarin  ---Tokens and the functions they serve, 19:53 — Scott Kupor, a16z managing partner ---Tokens and the ownership economy, 21:19 — Jesse Walden, Variant Fund founder, former a16z partner, and Mediachain founder  ---What tokens enable for creators, 22:18 — Ali Yahya, a16z general partner  Right Now ---What DeFi means, 23:58 — Eddy Lazzarin  ---Yield farming: What is it? 25:16 — Eddy Lazzarin  ---NFTs: What they are and why they matter, 27:15 — Linda Xie, Scalar Capital managing director, and Jesse Walden  ---Developer ecosystems, crypto, and composability, 30:17 — Jesse Walden  ---Decentralized networks, value capture, and what it means for builders, 33:05 — Ali Yahya  The Future ---The big picture, web3, and DAOs, 35:38 — Chris Dixon  For more crypto resources, please see our [Crypto Startup School] (https://a16z.com/crypto-startup-school/) page, our [documentary] (https://www.youtube.com/watch?v=jVehCoqJgYQ) about the program, and our [NFT Canon] (https://a16z.com/2021/04/02/nfts-readings-resources/) . ### The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information. ... Read more

17 Apr 2021

38 MINS

38:34

17 Apr 2021


#243

On Monetizing Community with Patreon Cofounder Sam Yam

It's clear from the growth of Patreon, Substack, TikTok, Clubhouse and many more that the power of the [Creator Economy] (https://a16z.com/tag/creator-economies/) continues to build. These platforms share one thing in common: They all enable independent creators to monetize their skills and products like never before. It's a trend that’s become increasingly relevant as the demand for virtual work grows. In this episode, first published a year ago, Patreon cofounder Sam Yam, Atelier Ventures' Li Jin (formerly a16z), and host Lauren Murrow discuss monetizing community, why creators today are effectively making more money off fewer fans, and what all of this means for the future of work. The discussion is based on [The Passion Economy and the Future of Work] (https://a16z.com/2019/10/08/passion-economy/) , a popular essay that first ran on a16z.com in October 2019. Check out that post and more creator content at:  [a16z.com/creatoreconomy] (https://a16z.com/tag/creator-economies/) . ... Read more

08 Apr 2021

26 MINS

26:15

08 Apr 2021


#242

The Creator Economy: NFTs and Beyond

In today’s episode of the a16z Podcast, we’re talking about the Creator Economy, and how NFTs (but not just NFTS!) are making it possible for artists, musicians, videogamers, game developers, and writers to create entirely new markets to make money from their work and engage with their fans. Part of this emerging picture is social tokens, which share a crypto foundation with NFTs, but unlike NFTs (which are non-fungible tokens, in which each token is unique), social tokens are typically fungible, meaning each token has the same value. (Listen to our explainer episode " [All About NFTs] (https://a16z.com/2021/03/27/nfts-explainer-faqs-hype-reality-innovation-crypto-creator-economy/) " with Sonal Choksi, Jesse Walden, and Linda Xie, or see our curated [NFT Canon] (https://a16z.com/2021/04/02/nfts-readings-resources/) for much more info on NFTs!) This hallway-style chat features a16z General Partner and crypto investor Chris Dixon, talking with Kevin Chou, who founded Kabam, and is the founder of Rally, an open network on Ethereum where creators can launch social tokens; and Jesse Walden, the founder of MediaChain, a music rights protocol that was acquired by Spotify; he’s now the founder of crypto venture fund Variant. They’ll talk about how musicians, artists, and writers can think about NFTs and social tokens as well, and how those different types of assets can interact to create models that haven’t existed before. But Chris starts off the discussion by talking about the emergence of crypto tokens, and a look at how videogames and gamers were early to the idea of community engagement and digital assets, and how that model is beginning to spread outward.   ... Read more

03 Apr 2021

33 MINS

33:44

03 Apr 2021


#241

All about NFTs

This episode is all about NFTs. It seems like nothing has caught on and spread into mainstream interest like NFTs, where one hears everything from "I've never seen anything like this before" to "is this like ICOs all over again" to "it's just a jpg I don't get it" to "but what about the energy use!" So, in this special deep-dive episode from the a16z Podcast network, we break down everything you need or want to know about NFTs -- while cutting through the noise for what’s hype/ what’s real, as well as where are on the long arc (and sometimes seemingly sudden tipping point!) of innovation (apparently, Google trends data [showed that] (https://thecontrol.co/stories-scarcity-and-mimetic-desire-c4a344fa74e1) interest in NFTs recently surpassed interest in cryptocurrency). Editor in chief Sonal Chokshi interviews friends of a16z crypto Linda Xie, co-founder of Scalar Capital and former Product Manager at Coinbase; and Jesse Walden, founder at Variant Fund and former co-founder of Mediachain Labs (which was acquired by Spotify, where he was then an R&D lead). Posted on both the a16z Podcast show and 16 Minutes -- as one of our "2-3x explainer episodes" of topics that keep coming up over and over again in the news (past such episodes have covered everything from [Section 230] (https://a16z.com/2020/05/31/16mins-section-230-communications-decency-act-content-moderation-free-speech-internet-past-present-future/) and [Tiktok] (https://a16z.com/2020/09/18/16mins-tiktok-seeing-like-an-algorithm-friendly-design-creativity-network-effects-video/) to [GPT-3] (https://a16z.com/2020/07/29/16mins-gpt3-natural-language-neural-net-deep-learning-few-shot-zero-shot/) and the [opioid crisis] (https://a16z.com/2019/08/04/16mins-news-opioid-crisis-dea-database/) ) -- this episode covers: ---what NFTs (non-fungible tokens) are -- as well as the properties of crypto that enable them, just to set some big-picture context; ---what forms they take, and what is and ISN’T an NFT -- including where “social tokens” and the [creator economy] (https://a16z.com/tag/creator-economies/) do and don’t come in; ---common myths and misconceptions -- from ‘just a jpg’ to the frequent question of energy use & NFTs; ---how they work -- as well as the broader ecosystem around NFTs, and different players; ---various applications, now and next -- touching briefly on how to think about NFTs, whether you’re an artist/ creator, developer, or institution. ...This episode is for everyone! transcript available at: https://a16z.com/2021/03/27/nfts-explainer-faqs-hype-reality-innovation-crypto-creator-economy image: [Mona Lisa] (https://commons.wikimedia.org/wiki/File:Da_Vinci%27s_Mona_Lisa_with_original_colors_approximation.jpg) / [Creative Commons 4.0] (https://creativecommons.org/licenses/by-sa/4.0/deed.en) ; changes made by Greg Truesdell per Sonal Chokshi, who dubbed it "The First 500 Years" [as a nod to] (https://onlineonly.christies.com/s/beeple-first-5000-days/lots/2020) Beeple's "The First 5000 Days" The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.   ... Read more

28 Mar 2021

56 MINS

56:23

28 Mar 2021


#240

The Next Wave of Marketplace Startups

In the tech world, marketplaces are a hot topic. That term—marketplace—encompasses a huge swath of services we use every day, from grocery delivery to online shopping to remote learning. How have marketplace dynamics changed since pre-pandemic, and what COVID-propelled consumer behaviors will persist into 2021 and beyond?   In this episode, we discuss the most promising marketplace companies and categories on the rise, based on data from the [Marketplace 100] (https://a16z.com/marketplace-100/) , a ranking of the largest and fastest-growing consumer-facing marketplace startups and private companies. The report provides rich fodder for looking ahead at the future of marketplaces: Which companies are on a tear and which are locked in close competition? Which marketplace categories are poised for growth, and which may make a comeback? Host [Lauren Murrow] (https://a16z.com/author/lauren-murrow/) is joined by a16z consumer team partners [Connie Chan] (https://a16z.com/author/connie-chan/) , [D’Arcy Coolican] (https://a16z.com/author/darcy-coolican/) , [Jeff Jordan] (https://a16z.com/author/jeff-jordan/) , and [Sriram Krishnan] (https://a16z.com/author/sriram-krishnan/) .   ... Read more

24 Mar 2021

27 MINS

27:01

24 Mar 2021


#239

The Third Vaccine, and Vaccine Choice

https://a16z.com/2021/03/15/16-minutes-58-the-johnson-johnson-vaccine-and-covid-efficacy-rates/ ... Read more

18 Mar 2021

12 MINS

12:48

18 Mar 2021


#238

Companies & Culture: What You Do Is Who You Are

This podcast -- which was recorded at the Computer History Museum in a live event, before the pandemic (first published in December 2019) is all about how companies create culture: A lot's changed... and a lot hasn't.  a16z editor in chief Sonal Chokshi interviews a16z co-founder Ben Horowitz -- author of [the book] (https://www.amazon.com/What-You-Do-Who-Are/dp/1094028649) What You Do Is Who You Are -- on whether companies and people can change; how the very thing that is your strength can also be your weakness; how startups evolve from pirates to the navy; actions vs words and values; and more. The discussion also covers common tropes that often come up in Silicon Valley folklore -- whether it’s “fake it til you make it” and the “reality distortion fields” of visionaries… vs. liars.  Drawing on historical themes and examples from a thousand years ago to today -- spanning empires, wars, revolutions, hip-hop, and prisons -- the discussion covers key themes and nuances, as well as practical advice, on creating company culture. Please note -- especially if you’re listening on smart speakers at home with children or with kids in a car -- that the discussion that follows includes various mentions of violence.  100% of the proceeds of the book go to anti-recidivism as well as towards helping Haiti.      Nick Quah, writer and publisher of Hot Pod (also at Vulture) joins a16z general partner Connie Chan -- and editor in chief (and showrunner of the a16z Podcast) Sonal Chokshi -- to talk about all this and more in this hallway-style jam.  ... Read more

09 Mar 2021

59 MINS

59:47

09 Mar 2021


#237

Boss Talk with Ben Horowitz

Boss Talk is a  weekly live show on Clubhouse, where a16z cofounder Ben Horowitz and Databricks CEO Ali Ghodsi discuss CEO stuff, leadership stuff, management stuff… you know, boss stuff. Here we share the second installment; in it, they explain Conway’s Law and shipping your org chart; how to transition from a boss to a boss of bosses; and their predictions for Silicon Valley post-pandemic. For more episodes of Boss Talk and other conversations from a16z, check out our separate feed, a16z Live. ... Read more

28 Feb 2021

59 MINS

59:38

28 Feb 2021


#236

All About Ransomware

In just the last couple years, ransomware has grown into a multibillion dollar industry. It has evolved from taking systems and servers hostage to stealing data, and it has proven capable of shutting down global organizations. In recent months, ransomware groups directly shut down Kia Motors North American IT systems; indirectly may have contributed to the death of a patient due to hospital ransomware; and allegedly stole sensitive files from a law firm whose clients include former President Trump. In this explainer episode, Tom Hofmann, the SVP of Intelligence at Flashpoint Intel (which monitors ransomware criminal syndicates and assists organizations with prevention and response) and a16z security operating partner cover: how ransomware works, from the anatomy of a hack to how the groups operate; the role of nation-states, insurers, and regulators; and what to do if your stuff is taken hostage. For more on cybersecurity, check out our coverage of organized cybercrime and hacks and our 16 step guide to protecting your data. ... Read more

25 Feb 2021

35 MINS

35:48

25 Feb 2021


#235

One on One with Marc and Ben

On social audio app Clubhouse, Marc Andreessen and Ben Horowitz are hosting a new live show called "One on One with A and Z", where they go deep on questions submitted via Twitter. The show is based in part by a newspaper column that Andy Grove did in the 80s, where readers sent in questions for him to answer in his column.  In this mega-episode of the a16z Podcast, we've combined their first two episodes into almost three hours of discussion and debate about some of the most important topics in entrepreneurship, tech, and culture. Each of these episodes also initially aired on our new show, a16z Live, which captures and share many of the live discussions and events featuring, hosted, or co-hosted by a16z partners (with outside voices too) on Clubhouse and beyond.  ... Read more

17 Feb 2021

3 HR 01 MINS

3:01:14

17 Feb 2021


#234

Amazon Narratives: Memos, Working Backwards from Release, More

When you hear stories about Amazon's "invention machine" -- which led to a company with not just one or two products but several successful diverse lines of business -- we often hear about things like: Memos, six pages exactly and no powerpoints at all!; or, the idea of just "work backwards from the press release"; and other such "best practices"... But what's often lost in hearing about these is the context and the details behind them -- the what, the how (as well as their origin stories) -- not to mention how they all fit together. Knowing this can give us insight into  how all companies and leaders, not just Amazon and Bezos, can define their cultures and ways especially as they scale. After all, Amazon was once a small startup, too. So in this a16z Podcast with Sonal Chokshi -- the very first podcast for the [new book] (https://www.amazon.com/Working-Backwards-Insights-Stories-Secrets/dp/1250788056) Working Backwards: Insights, Stories, and Secrets from Inside Amazon (out February 9) -- authors Colin Bryar and Bill Carr share not only how Amazon did it, but how other companies can do it, too, drawing on their combined 27 years of firsthand observations and experiences from being in "the room" where it happens. Bill was vice president of digital media, founded and led Amazon Music, Amazon Video, Amazon Studios; and Colin started out in the software group, was a technical vice president, and then, notably, was one of Jeff Bezos' earliest shadows -- the shadow before him was in fact Andy Jassy, president and CEO of Amazon Web Services (soon to be CEO of Amazon). The two share not only the early inside stories behind (ultimately) big business moves like AWS, Kindle, Prime -- but more importantly, the leadership principles, decision making practices, AND operational processes that got them there. Because "working backwards" is much, much more than being obsessed with your customers, or having company values like "are right a lot”, "insist on the highest standards", "think big", "bias for action", and more. The discussion also touches on hot-topic debates like to lean-MVP-or-not-to-be; the internal [API economy] (https://a16z.com/tag/the-api-economy/) ; do you even need a chief product officer; and if you need less, not more, coordination as you grow. Can startups really be like Amazon? Yes: and it comes down to how leaders, organizations, and people at all levels decide, build, invent... using the power of narratives and more. --- The views expressed here are those of the AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information. ... Read more

08 Feb 2021

1 HR 03 MINS

1:03:34

08 Feb 2021


#233

Anatomy of the SolarWinds Hack: Who What Where When How

In this special “3x”-long episode of our (otherwise shortform) news analysis show 16 Minutes -- past such 2-3X explainer episodes have covered [section 230] (https://a16z.com/2020/05/31/16mins-section-230-communications-decency-act-content-moderation-free-speech-internet-past-present-future/) , [Tiktok] (https://a16z.com/2020/09/18/16mins-tiktok-seeing-like-an-algorithm-friendly-design-creativity-network-effects-video/) , [ GPT-3] (https://a16z.com/2020/07/29/16mins-gpt3-natural-language-neural-net-deep-learning-few-shot-zero-shot/) , [the opioid crisis] (https://a16z.com/2019/08/04/16mins-news-opioid-crisis-dea-database/) , more -- we cover the SolarWinds hack, one of the largest (if not the largest!) publicly known hacks of all time... and the ripple effects are only now starting to be revealed. Just this week, the U.S. Cybersecurity and Infrastructure Security Agency shared ( [as reported in] (https://www.wsj.com/articles/suspected-russian-hack-extends-far-beyond-solarwinds-software-investigators-say-11611921601) the Wall Street Journal) that approximately 30% of both private-sector and government victims linked to the hack had no direct connection to SolarWinds. So who was compromised, do they even know, can they even know?! Because this hack is a supply-chain compromise involving various third-party software and services all connected together in a "chain of chains", the knock-on effects of it will be revealed (or not!) for years to come. So what do companies -- whether large enterprise, mid-sized startup, or small business -- do? What actually happened, and when does the timeline really begin? While first publicly revealed in December 2020 -- we first covered the news in [episode #49 here] (https://a16z.com/2020/12/15/16mins-us-treasury-hackers-ethereum-eth20-defi-scaling/) when it first [ broke] (https://www.reuters.com/article/us-usa-cyber-treasury-exclsuive/exclusive-u-s-treasury-breached-by-hackers-backed-by-foreign-government-sources-idINKBN28N0PG) , and there have been countless headlines since (about early known government [agency victims] (https://www.washingtonpost.com/national-security/dhs-is-third-federal-agency-hacked-in-major-russian-cyberespionage-campaign/2020/12/14/41f8fc98-3e3c-11eb-8bc0-ae155bee4aff_story.html) , [company investigations] (https://msrc-blog.microsoft.com/2020/12/31/microsoft-internal-solorigate-investigation-update/) , [other tool investigations] (https://www.nytimes.com/2021/01/06/us/politics/russia-cyber-hack.html) , [debates over who and how] (https://www.axios.com/solarwinds-hack-russia-trump-blame-game-683eca31-ff57-4582-b6a7-5e31c0787c94.html) and so on) -- the hack actually began not just a few months but years earlier, involving [early tests] (https://news.yahoo.com/hackers-last-year-conducted-a-dry-run-of-solar-winds-breach-215232815.html) , legit domains, and a very long game. We help cut through the headline fatigue of it all, tease apart what's hype/ what's real, and do an "anatomy of a hack" step-by-step teardown -- the who, what, where, when, how; from the chess moves to technical details -- in an in-depth yet accessible way with Sonal Chokshi in conversation with a16z expert and former CSO Joel de la Garza and outside expert Steven Adair, founder and president of [Volexity] (https://www.volexity.com/) . The information security firm (which specializes in incident response, digital forensics/ memory analysis, network monitoring, and more) not only posted [guidance for responding] (https://www.volexity.com/blog/2020/12/16/responding-to-the-solarwinds-breach/) to such attacks, but also [an analysis] (https://www.volexity.com/blog/2020/12/14/dark-halo-leverages-solarwinds-compromise-to-breach-organizations/) based on working three separate incidents involving the SolarWinds hackers. But how did they know it was the same group? And why was it not quite the perfect crime? image: Heliophysics Systems Observatory spacecraft characterize, in the highest cadence, the constant stream of particles exploding from the sun affect Earth, the planets, and beyond via [NASA Goddard Space Flight Center] (https://www.flickr.com/photos/gsfc/16149052746/) / [Flickr] (https://creativecommons.org/licenses/by/2.0/) ... Read more

01 Feb 2021

47 MINS

47:55

01 Feb 2021


#232

Psychedelics: Striking a Balance Between Benefits and Side Effects

In recent years, there’s been a shift in how we think about psychedelics – from drugs of abuse and recreation, to powerful drugs for treating neuropsychiatric conditions such as depression, addiction, and PTSD.   But there’s still a lot we don't know about how they work, and how we can maximize their therapeutic benefits while minimizing their adverse side effects. So this episode of Journal Club discusses a method for striking that balance, from a paper published in Nature last month, “ [A non-hallucinogenic psychedelic analogue with therapeutic potential] (https://doi.org/10.1038/s41586-020-3008-z) “... which could represent a major step forward in psychedelic medicine.  This episode first appeared on Bio Eats World: https://a16z.com/2021/01/21/journal-club-safer-psychedelic/ ... Read more

23 Jan 2021

26 MINS

26:19

23 Jan 2021


#231

Developers as Creatives

The rise of developers -- as buyers, as influencers, as a creative class -- is a direct result of "software eating the world", and of key shifts in IT from on-prem to cloud & SaaS to [the API economy] (https://a16z.com/tag/the-api-economy/) , where application programming interfaces are essentially building blocks for innovation. Developers therefore not only play an outsized role in high-performing tech companies -- but managing and motivating them is actually critical in ALL companies, since every company is a tech company (whether they know it or not). As every industry turns digital, and a company's interface to their customers IS software, "asking" one's developer is the key to solving business problems and to thriving not just surviving, argues Jeff Lawson, CEO and co-founder of cloud communications platform-as-a-service company [Twilio] (https://www.twilio.com/) , in his  [new book] (https://www.askyourdeveloper.com/) , Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century. So in this episode of the a16z Podcast in conversation with Sonal Chokshi and David Ulevitch (who previously argued " [the developer's way] (https://a16z.com/2020/01/09/the-developers-way/) " is the future of work), Lawson shares hard-earned lessons learned, mindsets, strategies, and tactics -- from "build vs. buy" to "build vs. die", to the art and science of small teams ("mitosis") -- for leaders and companies of all sizes. But what does it mean to truly treat developers as creatives within an organization? What does it mean to be "developer first"? And how does this affect customers, product, go-to-market? All this and more in this episode. ... Read more

13 Jan 2021

33 MINS

33:19

13 Jan 2021


#230

Section 230: Everything You Need to Know -- Tweets, Free Speech, Beyond

All about section 230 of the Communications Decency Act -- in what Wired senior writer (and host of the Get Wired podcast) [described] (https://twitter.com/LaurenGoode/status/1321201684232630272) as "one of the clearest-but-still-nuanced explainers I've heard - worth listening to".  So what does and doesn't it say? How does this law play out against broader questions and debates around platforms, content moderation, and free speech? This conversation between Mike Masnick (founder and editor in chief of Techdirt) and a16z editor in chief Sonal Chokshi was [originally published] (https://a16z.com/2020/05/31/16mins-section-230-communications-decency-act-content-moderation-free-speech-internet-past-present-future/) on our show 16 Minutes, in the context of previous protests and presidential tweets (and an executive order then to prevent “online censorship”)-- but is exactly as relevant today... perhaps now more than ever. https://a16z.com/2020/05/31/16mins-section-230-communications-decency-act-content-moderation-free-speech-internet-past-present-future/ image: presidential tweet activity/ Wikimedia Commons ... Read more

09 Jan 2021

39 MINS

39:38

09 Jan 2021


#229

Baumol's Cost Disease, in Healthcare... and Where We Go Next

If software’s eating the world -- and more specifically, bringing costs down and increasing productivity through entire industries -- why have some industries, like healthcare, been so resistant? And what could the future look like once technology really gets in?  With a16z co-founder -- and author of the now nearly decade-old thesis of “software eating the world” -- Marc Andreessen, in conversation with a16z bio general partner Vijay Pande. This episode originally ran on our show Bio Eats World, but we’re sharing it here in the new year as it’s very relevant for ANYone interested in, well, the future of software eating the world;)   https://a16z.com/2020/12/14/cost-disease-healthcare-baumol/ ... Read more

06 Jan 2021

30 MINS

30:01

06 Jan 2021


#228

Words of 2020! (and Metaphors, and Interfaces of the Year)

"In a year that left us speechless, 2020 has been filled with new words unlike any other”... so it's unprecedented that for the first time, the Oxford English Dictionary [did NOT] (https://www.theguardian.com/books/2020/nov/23/oed-says-2020-too-many-potential-words-of-the-year-to-name-just-one-oxford-english-dictionary) name a word of the year. But do we really need the dictionaries to tell us what our words of the year are? Especially if the approaches "Big Word" takes may be based on more lagging vs. leading indicators; after all, language is created and constructed as we go. And yet. People want the dictionary to give them permission of "tell me what the words are", observes internet linguist (and author of the NYT bestselling book [Because Internet] (https://gretchenmcculloch.com/book/) : Understanding the New Rules of Language) Gretchen McCulloch. No! We, the people, decide what the words are!! So in this special holiday, end-of-year episode, a16z Podcast showrunner Sonal Chokshi chats with McCulloch about the words of the year in and beyond Oxford's "Words of an Unprecedented Year" [report] (https://languages.oup.com/word-of-the-year/2020/) -- and importantly, the tech shifts and cultural shifts behind them. From remote work portmanteaus to scientific discourse in a pandemic (for better and for worse) to social movements and more -- we take a whirlwind tour through the words of the year, exploring [misplaced analogies] (https://www.tandfonline.com/doi/full/10.1080/10410236.2020.1844989) , shifting metaphors, and even the evolution of interfaces. We dip into the settling of the "Zoomer" generation and "moonshots"; dive into the need for "third places" and [parties] (https://www.wired.com/story/zoom-parties-proximity-chat/) ; debate Dunbar numbers for conversations, and the trend of "proximity chat" -- and discuss the meta story of language, and of writing itself. The English language may have resulted from network effects involving the "loners" who introduce words, and the “leaders” who spread them; but writing is a technology that spreads with the tools, going well beyond medium/message, connecting us across time and place and online spaces.   image: [Andy Simmons] (https://www.flickr.com/photos/andysimmons/4573786830/) / [Flickr] (https://creativecommons.org/licenses/by-nd/2.0/) ... Read more

24 Dec 2020

51 MINS

51:29

24 Dec 2020


#227

The Machine That Made the Vaccine: Company, Platform, Innovation

In this special episode of Bio Eats World -- which aired right after the FDA authorized Moderna's mRNA vaccine for emergency use -- Moderna CEO Stephane Bancel tells the story of not just the vaccine’s development, but the machine that made the vaccine: the platform, the technology, and the moves behind the vaccine’s development. How does this new technology that uses mRNA work; why is this such a fundamental shift in the world of drug development; and where will this technology go next?   https://a16z.com/2020/12/18/moderna-covid-vaccine-mrna-technology/ ... Read more

21 Dec 2020

40 MINS

40:04

21 Dec 2020


#226

The PPP Omnibus: Eminent Domain, Fraud, and Fintech

This episode features two relevant but previously recorded episodes, discussing the relevance of the Paycheck Protection Program (or PPP) from the Small Business Administration and the role of government stimulus/ pandemic relief for the economy as well as where tech comes in.  It combines 2 separate episodes, beginning with one recorded much earlier this year (on our show 16 Minutes), which outlines a useful analogy of "eminent domain" for government-mandated shutdowns of certain businesses and technology considerations; and then is followed by an episode (recorded later this year) on preventing fraud and the role of fintech.  Both episodes feature in common a16z general partner in fintech Alex Rampell, who also wrote about how Small Businesses Depend on the Stimulus Package, and The Stimulus Will Depend on Fintech, which you can find at: a16z.com/pandemicstimulus ... Read more

14 Dec 2020

59 MINS

59:26

14 Dec 2020


#225

The Holy Grail of Social + Fintech

The intersection of social and finance—as well as shifting attitudes around what we share about money online—have given way to an ambitious new wave of financial products. While revealing one’s financial information was once considered taboo, now people are more apt than ever to openly discuss money online, particularly [Gen Z and millennials] (https://a16z.com/2020/10/01/fintech-for-gen-z/) . That’s evident on both ends of the spectrum, whether people are bemoaning their crushing levels of student debt on Twitter and Instagram or bragging about their latest stock trades on WallStreetBets. The repercussions extend far beyond social media, fueling a wave of new social-fintech products like Public, Commonstock, and Doji, among others. In this conversation between fintech partner [Anish Acharya] (https://a16z.com/author/anish-acharya/) , formerly a product manager at Credit Karma, consumer partner [D’Arcy Coolican] (https://a16z.com/author/darcy-coolican/) (who himself is a former founder in this space), and host [Lauren Murrow] (https://a16z.com/author/lauren-murrow/) , we discuss why the “holy grail” of social plus finance is both so challenging and, potentially, so rewarding.  This episode was originally released last year and has been resurfaced as part of [Social Strikes Back] (https://a16z.com/social-strikes-back) , a new series exploring the next generation of social networks and how they’re shaping the future of consumer tech. See more at [a16z.com/social-strikes-back] (https://a16z.com/social-strikes-back) . ... Read more

07 Dec 2020

24 MINS

24:05

07 Dec 2020


#224

On Fear and Leadership: Product to Sales CTOs & CEOs

There's a few ontologies for describing the phases leaders -- and their startups -- go through, whether it's product-sales-etc. or pioneer to settler. In any case, as companies evolve, so must the leaders -- but can the same person transition across all these phases? When and when not; what are the qualities, criteria, and tradeoffs to be made? In this episode of the a16z Podcast, originally recorded as an internal hallway-style chat (pre pandemic!) a16z general partner Martin Casado, who co-founded but decided to remain CTO of Nicira -- and [previously shared] (https://a16z.com/2020/03/06/external-ceo-founders-startups-when-how-nicira-story/) his own journey, lessons learned, and advice for founders about bringing in an external CEO and the question of "to CTO or not to CTO" -- and Armon Dadgar, co-founder (with Mitchell Hashimoto) and CTO of [HashiCorp] (https://www.hashicorp.com/) , chat with Sonal Chokshi about both managing their past psychology through these common questions and decisions. They also share their strategies on managing the specific tactics behind it all: Everything from the "dating" process of finding an external CEO to figuring out swim lanes; handling debates and decisions; who presents, who sells. And while the conversation is a brief glimpse into their longer personal journeys, there's lessons in it for startups and leaders of all kinds on the art of hiring and sales, managing credit and conflict, and more... ... Read more

04 Dec 2020

42 MINS

42:44

04 Dec 2020


#223

On Food As Medicine (A Holiday Snack)

What happens if we treat food as a medicine in the healthcare system: How, where, and who (pays)? What role can technology play in increasing access, distribution, and more?  General partner Julie Yoo talks with the founder and former medical director of Geisinger Fresh Food Farmacy, Dr. Andrea Feinberg, and with the co-founder of food delivery start up Plated in this "holiday" cross-promo of our show Bio Eats World.  ... Read more

26 Nov 2020

20 MINS

20:04

26 Nov 2020


#222

Crypto Creators: On Art Galleries to 'Tokenized' Collectibles

This episode features Q&As with two artists who are exploring crypto-powered auction sites and marketplaces – this is part of our ongoing series on the creator economy. The big picture is that emerging "tokenization" models, especially non-fungible tokens, or NFTs, are creating new ways for collectors and investors to buy, sell, and trade digital art. More broadly, these innovations open the door to the tokenization of any products or collectibles that can be captured and owned digitally.  Marketplaces powered by NFTs open up new revenue streams for creators, because anytime digital work is resold or their tokens traded on these platforms, no matter how many times, the creator gets a percentage of those secondary sales. It's all transparent and governed by code on the blockchain, and it’s a big shift in creator economies. Our first guest is one of the biggest names in crypto art, and one of the most mysterious. Murat Pak is the artist and industrial designer who created the AI-powered image sharing site Archillect. Pak has made it a policy to separate their personal identity from their online work, and prefers to keep their quote-unquote real identity hidden, so we conducted this interview by email and converted Pak’s answers to audio using text-to-speech software. As Pak has expressed in other interviews, it's really the work that matters. And we do know a lot about the work, Pak has sold more than 60 pieces of digital art this year on the auction site SuperRare, for more than $350,000. And that’s just one of the several platforms on which Pak’s work is sold.  In this Q&A, Pak talks with a16z's Zoran Basich about NFTs. These "non-fungible tokens" are unique assets that are not interchangeable. Dollar bills are fungible — each dollar bill is worth exactly the same as every other one. But works of art, for example, or any collectible, can be non-fungible — their value varies based on the market for that particular asset. With crypto, these assets carry digital ownership rights that can be easily exchanged. We start by discussing the whole concept of digital art, and why anyone would pay for something that (seemingly) can be easily copied. Our second interview is with Signe Pierce, a visual, digital, and performance artist whose work has appeared in major galleries in Paris, Los Angeles, and New York. She’s currently featuring her artwork on the creator marketplace Foundation. On that site, in addition to auction-style NFT markets, the price of tokens associated with individual works of art is something like you’d see on a stock market – the pricing is real-time, and dynamic and fluctuates according to demand by buyers, who might be investors, collectors, or fans. Signe discusses why she went from working exclusively with galleries to trying crypto marketplaces, how this move affects her work and her business, and how crypto could change the way she engages with her fans. She also offers advice for creators interested in getting into the world of crypto. She starts off by talking about how social media popularity several years ago opened her eyes to the idea of new monetization models for creators.  ... Read more

22 Nov 2020

20 MINS

20:12

22 Nov 2020


#221

What to Know about Those Vaccines

A vaccine for COVID seems to be (almost) here… or is it? What’s hype/ what’s real beyond the headlines (and beyond the press release), when it comes to the [announcement] (https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against) last week from Pfizer and BioNTech that their vaccine candidate was found to be more than 90% effective in preventing COVID-19 -- and relatedly, the most recent news around Moderna's vaccine candidate?  Of course, this was just the first interim efficacy analysis — so how close or far are we? What’s the significance of the readout and case numbers? How do we put all this in context of all the other (458!) programs in development? And how much should/ shouldn’t we read into the news, given the buzzy excitement and penchant for evaluating "science via press release"? a16z bio general partners Vineeta Agarwala and Jorge Conde recently broke it all down in conversation with Sonal Chokshi on our show 16 Minutes: the math, the science, and the practical considerations — from “vaccine efficacy” vs. efficiency, from cold chains to distribution, from patients to the system… as well as why mRNA matters in the present future of vaccines. ... Read more

20 Nov 2020

21 MINS

21:59

20 Nov 2020