ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson podcast

ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson

A single scientific breakthrough changed the future of humanity, setting off the third great revolution of modern times. As with any revolution, things didn’t happen neatly or quietly. One figure stood at the center of it all: Jennifer Doudna, the Nobel Prize-winning biochemist who co-created CRISPR. Her invention signified the arrival of a newfound ability to edit our genes, as simply as we edit a sentence, with a word processor. From Walter Isaacson - the bestselling biographer behind Musk, Einstein and Steve Jobs – and journalist Evan Ratliff (Mastermind, co-host of the beloved Longform podcast) comes a behind the scenes look at the story of Jennifer Doudna. Her personal trajectory, and that of her collaborators and competitors, tells the story of how we arrived at this new frontier of gene editing. It’s a story filled with global stakes and fiery competition. And a story that touches upon the ethical considerations that gene editing brings. Season 2: He didn’t have a role in Hamilton, but America wouldn’t be the same without him! From Walter Isaacson– the bestselling biographer behind Musk, Einstein and Steve Jobs– and journalist Evan Ratliff (Mastermind, co-host of the beloved Longform podcast) comes a behind the scenes look at the story of Ben Franklin, and how his genius shaped our national character. From Franklin’s adventures as a mischievous apprentice, to his evolution over 84 years into America’s best writer, inventor,scientist, diplomat, and business strategist… as well as Founding Father, Isaacson covers everything from the wit behind Poor Richard’s Almanac to the wisdom behind the Declaration of Independence; not to mention, how a former slave owner evolved into the shepherd of a near-perfect Constitution. In this intimate behind the scenes interview, Isaacson provides a look at how he came to understand Franklin’s remarkable life, how it shaped America’s national identity, and why Ben Franklin matters so much right now. Season 1: What is it like to shadow Elon Musk for two years? To sit courtside as he builds a rocket? Or tears apart an engineer? Or couch surfs at the homes of billionaires? And how on earth do you make sense of it all? Walter Isaacson is the biographer of giants: DaVinci, Franklin, Doudna, Jobs...and now Musk, former enfant terrible, rocket launcher, electric car innovator, and Twitter—er, X—disruptor, to put it gently. In this four-part series, author Evan Ratliff (“Mastermind,” “Longform” Podcast) sits down with Isaacson to draw out the behind-the-scenes stories of this epic biography, and what the writer has learned as an outsider inside Silicon Valley.

A single scientific breakthrough changed the future of humanity, setting off the third great revolution of modern times. As with any revolution, things didn’t happen neatly or quietly. One figure stood at the center of it all: Jennifer Doudna, the Nobel Prize-winning biochemist who co-created CRISPR. Her invention signified the arrival of a newfound ability to edit our genes, as simply as we edit a sentence, with a word processor. From Walter Isaacson - the bestselling biographer behind Musk, Einstein and Steve Jobs – and journalist Evan Ratliff (Mastermind, co-host of the beloved Longform podcast) comes a behind the scenes look at the story of Jennifer Doudna. Her personal trajectory, and that of her collaborators and competitors, tells the story of how we arrived at this new frontier of gene editing. It’s a story filled with global stakes and fiery competition. And a story that touches upon the ethical considerations that gene editing brings. Season 2: He didn’t have a role in Hamilton, but America wouldn’t be the same without him! From Walter Isaacson– the bestselling biographer behind Musk, Einstein and Steve Jobs– and journalist Evan Ratliff (Mastermind, co-host of the beloved Longform podcast) comes a behind the scenes look at the story of Ben Franklin, and how his genius shaped our national character. From Franklin’s adventures as a mischievous apprentice, to his evolution over 84 years into America’s best writer, inventor,scientist, diplomat, and business strategist… as well as Founding Father, Isaacson covers everything from the wit behind Poor Richard’s Almanac to the wisdom behind the Declaration of Independence; not to mention, how a former slave owner evolved into the shepherd of a near-perfect Constitution. In this intimate behind the scenes interview, Isaacson provides a look at how he came to understand Franklin’s remarkable life, how it shaped America’s national identity, and why Ben Franklin matters so much right now. Season 1: What is it like to shadow Elon Musk for two years? To sit courtside as he builds a rocket? Or tears apart an engineer? Or couch surfs at the homes of billionaires? And how on earth do you make sense of it all? Walter Isaacson is the biographer of giants: DaVinci, Franklin, Doudna, Jobs...and now Musk, former enfant terrible, rocket launcher, electric car innovator, and Twitter—er, X—disruptor, to put it gently. In this four-part series, author Evan Ratliff (“Mastermind,” “Longform” Podcast) sits down with Isaacson to draw out the behind-the-scenes stories of this epic biography, and what the writer has learned as an outsider inside Silicon Valley.

 

#17

ON CRISPR Episode 5: The Conversation

In the four years since the book’s publication, CRISPR has revolutionized the world ... more

08 Oct 2025

59 MINS

59:01

08 Oct 2025


#16

ON CRISPR Episode 4: Franken Monsters

As the gene editing field kept growing, so did the dangers. Back in 2018, Jennifer Doudna ... more

01 Oct 2025

36 MINS

36:47

01 Oct 2025


#15

ON CRISPR Episode 3: Patent Wars

Jennifer Doudna thought she had won the race. She thought she had beaten out all scientifi... more

24 Sep 2025

27 MINS

27:19

24 Sep 2025


#14

ON CRISPR Episode 2: The Discovery

Back in the 1990s, a young microbiologist in Alicante, Spain became obsessed with a strang... more

17 Sep 2025

30 MINS

30:50

17 Sep 2025


#13

ON CRISPR Episode 1: Beginnings

Earlier this year, when the world learned the news of baby KJ successfully undergoing the ... more

10 Sep 2025

26 MINS

26:29

10 Sep 2025


#12

ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson

Walter Isaacson - bestselling biographer behind Musk, Einstein and Steve Jobs - in convers... more

04 Sep 2025

03 MINS

03:27

04 Sep 2025


#11

ON BENJAMIN FRANKLIN Episode 5: Legacy

In this final episode of our series, host Evan Ratliff and biographer Walter Isaacson disc... more

03 Oct 2024

35 MINS

35:46

03 Oct 2024


#10

ON BENJAMIN FRANKLIN Episode 4: The Statesman

After retiring at the age of 42, Ben Franklin immersed himself in politics, taking on enor... more

19 Sep 2024

37 MINS

37:46

19 Sep 2024


#9

ON BENJAMIN FRANKLIN Episode 3: Industry

Few people remember that Benjamin Franklin was America’s wealthiest self-made man. After b... more

12 Sep 2024

29 MINS

29:10

12 Sep 2024


#8

ON BENJAMIN FRANKLIN Episode 2: The Great American Character

From writing under pen names in the newspaper as a teenager, to the Poor Richard maxims we... more

05 Sep 2024

32 MINS

32:33

05 Sep 2024


#7

ON BENJAMIN FRANKLIN Episode 1: Ingenuity

From Walter Isaacson– the bestselling biographer behind Musk, Einstein and Steve Jobs– and... more

29 Aug 2024

27 MINS

27:55

29 Aug 2024


#6

Introducing Season 2: ON Benjamin Franklin with Walter Isaacson

Introducing ON Benjamin Franklin with Walter Isaacson - an intimate behind the scenes inte... more

22 Aug 2024

02 MINS

02:48

22 Aug 2024


#5

ON Musk Episode Four: What is Musk’s Legacy?

Which of Musk’s efforts will mark his legacy? Will it be Starship and his work bringing Am... more

12 Dec 2023

43 MINS

43:24

12 Dec 2023


#4

ON Musk Episode Three: Storytelling and Hot Takes

Be a storyteller, not a preacher. That was novelist Walker Percy’s legendary advice to a y... more

12 Dec 2023

44 MINS

44:40

12 Dec 2023


#3

ON Musk Episode Two: Demons

What kind of titan of industry has a "giddy mode"? Or a "demon mode"? The two aspects of M... more

12 Dec 2023

42 MINS

42:54

12 Dec 2023


#2

ON Musk Episode One: Genius

Space travel, electric vehicles, future-powering batteries—the ability to push technology ... more

12 Dec 2023

31 MINS

31:45

12 Dec 2023


#1

Introducing: On Musk with Walter Isaacson

See [omnystudio.com/listener] (https://omnystudio.com/listener) for privacy information.

05 Dec 2023

03 MINS

03:23

05 Dec 2023