In this episode we discuss:
 
<ul>
<li>
How glucose and insulin decrease glycation
</li>
<li>
Why ketogenic diets can be worse than high-carb diets when it comes to AGE formation
</li>
<li>
How autophagy helps to clear AGEs, but increasing autophagy is not the answer
</li>
<li>
The true primary drivers of AGE accumulation
</li>
<li>
The best diet and supplements for minimizing glycation
</li>
</ul>
 
Check out the Energy Balance Solution program here: <a href='https://www.jayfeldmanwellness.com/solution/'>https://www.jayfeldmanwellness.com/solution/</a> 
 
Click here to check out the show notes: 
<a href='https://www.jayfeldmanwellness.com/eb-138-low-carb-diets-increase-glycation-and-what-to-do-instead/'>https://www.jayfeldmanwellness.com/eb-138-low-carb-diets-increase-glycation-and-what-to-do-instead/</a> 

 

Timestamps:
0:00 – intro 
0:57 – how glycation products are detoxified and cleared from the body 
4:03 – glycation detoxification is impaired by oxidative stress and inflammation, as seen in type 2 diabetes 
7:56 – the benefits of carbohydrates for the detoxification of glycation products 
10:42 – the benefits of insulin for the detoxification of glycation products 
12:45 – how AGEs are cleared 
14:36 – increasing autophagy via hormesis is not the answer for clearing AGEs 
19:09 – autophagy can drive disease 
20:50 – ATP protects against oxidative stress and allows for proper autophagy when needed 
24:37 – impaired mitochondrial along with fatty acid oxidation impairs autophagy and increases oxidative stress 
26:54 – carbohydrates do NOT inhibit autophagy 
29:18 – adequate thyroid hormone supports proper autophagy 
30:15 – adequate ATP and mitochondrial function is needed for the UPS (ubiquitin proteasome system) 
32:56 – do high-carb diets actually impair metabolism and insulin sensitivity 
35:26 – is fructose really worse for blood sugar regulation and glycation? 
37:16 – are low-carb or ketogenic diets the solution to reduce glycation? 
40:32 – increased glycation and oxidative stress on ketogenic diets 
44:09 –low-carb diets don’t prevent glucose exposure 
47:56 – there are still considerable insulin and glucose excursions on low-carb diets 
50:06 – gluconeogenesis leads to same glycolytic intermediates as glucose metabolism 
51:52 –the main driver of AGE formation and impaired AGE clearance 
53:40 – the role of vitamin B1 (thiamine) and mitochondrial energy production in decreasing AGEs 
56:27 –endotoxin as a driver of glycation and increased AGE production 
58:12 – hypothyroidism as a driver of glycation and AGE accumulation 
59:37 – dietary solutions for reducing glycation and AGEs 
1:03:33 – how to support the glyoxalase pathway to support the detoxification of glycation products 
1:05:56 – avoid calorie restriction, low-carb diets, fasting, resveratrol, cold exposure, excess exercise, and iron overload to decrease glycation and AGEs 
1:07:33 – iron as a double-edged sword for oxidative stress

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EB. 138: How Low-Carb Diets Worsen AGE Formation (and What to Do Instead)

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