Where does your Python code actually run? A server in Virginia? A container in Frankfurt? Pyodide put Python into the browser. Cloudflare put the browser into the server. Combine the two and you get Python Workers, now generally available. My guests are Hood Chatham, Gyeongjae Choi, and Dominik Picheta from Cloudflare. Hood and Gyeongjae maintain Pyodide. Dominik got Python running in Cloudflare Workers in the first place. Your FastAPI app ships as plain Python files. It runs on CPython compiled to WebAssembly, inside V8, at over 350 locations worldwide. 
 
Episode sponsors 
 
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<h2 class="links-heading mb-4">Links from the show</h2>
<div>Guests 
Gyeongjae Choi: <a href="https://www.linkedin.com/in/gyeongjae-choi-b259b0163?featured_on=talkpython" target="_blank" >linkedin.com</a> 
Hood Chatham 
Dominik Picheta 
 
Pyodide: <a href="https://pyodide.com?featured_on=talkpython" target="_blank" >pyodide.com</a> 
Python Everywhere: The State of Python on WebAssembly - Hood Chatham, Gyeongjae Choi: <a href="https://www.youtube.com/watch?v=HklunTc9giA" target="_blank" >www.youtube.com</a> 
PEP 783: <a href="https://peps.python.org/pep-0783/?featured_on=talkpython" target="_blank" >peps.python.org</a> 
D1 Databases: <a href="https://www.cloudflare.com/products/d1/?featured_on=talkpython" target="_blank" >www.cloudflare.com</a> 
Hyperdrive: <a href="https://www.cloudflare.com/products/hyperdrive/?featured_on=talkpython" target="_blank" >www.cloudflare.com</a> 
R2 Object Storage: <a href="https://www.cloudflare.com/products/r2/?featured_on=talkpython" target="_blank" >www.cloudflare.com</a> 
Queues: <a href="https://developers.cloudflare.com/queues/?featured_on=talkpython" target="_blank" >developers.cloudflare.com</a> 
AI: <a href="https://www.cloudflare.com/products/workers-ai/?featured_on=talkpython" target="_blank" >www.cloudflare.com</a> 
now generally available: <a href="https://blog.cloudflare.com/python-workers-ga/?featured_on=talkpython" target="_blank" >blog.cloudflare.com</a> 
Memory Snapshots for CPython (Python Language Summit 2026\): <a href="https://blog.python.org/2026/09/language-summit-2026-memory-snapshots/?featured_on=talkpython" target="_blank" >blog.python.org</a> 
Cloudflare Worker Limits: <a href="https://developers.cloudflare.com/workers/platform/limits/?featured_on=talkpython" target="_blank" >developers.cloudflare.com</a> 
Litestream: <a href="https://litestream.io?featured_on=talkpython" target="_blank" >litestream.io</a> 
workerd: <a href="https://github.com/cloudflare/workerd?featured_on=talkpython" target="_blank" >github.com</a> 
Are we PEP 783 yet?: <a href="https://pyodide.github.io/are-we-pep783-yet/?featured_on=talkpython" target="_blank" >pyodide.github.io</a> 
The Birth & Death of JavaScript: <a href="https://www.destroyallsoftware.com/talks/the-birth-and-death-of-javascript?featured_on=talkpython" target="_blank" >www.destroyallsoftware.com</a> 
 
Watch this episode on YouTube: <a href="https://www.youtube.com/watch?v=Kgh9-p7yb9A" target="_blank" >youtube.com</a> 
Episode #568 deep-dive: <a href="https://talkpython.fm/episodes/show/568/cloudflare-python-workers#takeaways-anchor" target="_blank" >talkpython.fm/568</a> 
Episode transcripts: <a href="https://talkpython.fm/episodes/transcript/568/cloudflare-python-workers" target="_blank" >talkpython.fm</a> 
 
Theme Song: Developer Rap 
🥁 Served in a Flask 🎸: <a href="https://talkpython.fm/flasksong" target="_blank" >talkpython.fm/flasksong</a> 
 
---== Don't be a stranger ==--- 
YouTube: <a href="https://talkpython.fm/youtube" target="_blank" > youtube.com/@talkpython</a> 
 
Bluesky: <a href="https://bsky.app/profile/talkpython.fm" target="_blank" >@talkpython.fm</a> 
Mastodon: <a href="https://fosstodon.org/web/@talkpython" target="_blank" > @talkpython@fosstodon.org</a> 
X.com: <a href="https://x.com/talkpython" target="_blank" > @talkpython</a> 
 
Michael on Bluesky: <a href="https://bsky.app/profile/mkennedy.codes?featured_on=talkpython" target="_blank" >@mkennedy.codes</a> 
Michael on Mastodon: <a href="https://fosstodon.org/web/@mkennedy" target="_blank" > @mkennedy@fosstodon.org</a> 
Michael on X.com: <a href="https://x.com/mkennedy?featured_on=talkpython" target="_blank" > @mkennedy</a> </div>

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