Your butt is not about aesthetics. It is a longevity organ that directly&nbsp;impacts&nbsp;metabolism, brain optimization, resilience, and how long you stay strong as you age. In this episode,&nbsp;you’ll&nbsp;learn why strength training and protein intake matter more than body fat percentage, how mitochondria drive human performance and recovery, and why building muscle protects your brain, stabilizes mood, and supports long-term longevity. This conversation&nbsp;reframes&nbsp;biohacking, anti-aging, and health from weight loss to muscle span, the length of time you live with strong, functional skeletal muscle.&nbsp;Watch this episode on YouTube for the full video experience:&nbsp;<a href="https://www.youtube.com/@DaveAspreyBPR" rel="noopener noreferrer" target="_blank">https://www.youtube.com/@DaveAspreyBPR</a>&nbsp;Host Dave Asprey sits down with Gabrielle Lyon, an accomplished physician and New York Times bestselling author of Forever Strong: A New, Science-Based Strategy for Aging Well, and author of the upcoming The Forever Strong Playbook, releasing January 27, 2026. Dr. Lyon pioneered the Muscle-Centric Medicine® approach, which places muscle at the center of disease prevention, metabolic health, and true vitality. She has trained elite athletes, military operatives, and public figures, while also&nbsp;living&nbsp;this philosophy at home as a mother of two with her husband, a retired Navy SEAL.&nbsp;Together, they break down why intermuscular fat may matter more than body fat percentage, how skeletal muscle drives insulin sensitivity and lowers inflammation, and why becoming physically stronger improves brain function and neuroplasticity. They explore protein needs across the lifespan, fasting, ketosis, carnivore-style nutrition, supplements, sleep optimization, and the real tradeoffs of GLP-1 drugs, including the risk of accelerated muscle loss if strength and protein are neglected. The conversation also covers mindset, hormesis, and why physical resilience creates emotional regulation and clearer decision-making in a world increasingly shaped by AI and convenience.&nbsp;This episode is essential listening for anyone serious about biohacking, hacking human performance, longevity, mitochondria, neuroplasticity, nootropics, metabolism, functional medicine, anti-aging strategies, supplements, and living Smarter Not Harder, ideally with a cup of Danger Coffee in hand.&nbsp;You’ll&nbsp;Learn:&nbsp;• Why your glutes and skeletal muscle are critical drivers of longevity and brain health&nbsp;• Why intermuscular fat can matter more than body fat percentage for metabolic dysfunction&nbsp;• How strength training improves neuroplasticity, cognition, and emotional resilience&nbsp;• Why protein needs increase with age and why outdated limits can hold you back&nbsp;• What GLP-1 drugs get right, where they fail, and how to protect muscle span&nbsp;• Why progressive stimulus beats lifting heavy for long-term strength and injury prevention&nbsp;• How sleep optimization and recovery support mitochondria and human performance&nbsp;• How building muscle creates clarity, resilience, and better decision-making&nbsp;Dave Asprey is a&nbsp;four time&nbsp;New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and&nbsp;optimize&nbsp;every system in the body and mind. Each episode features&nbsp;cutting edge&nbsp;insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.&nbsp;Thank you to our sponsors!&nbsp;<ul><li>Quantum Upgrade | Support your brain, energy, focus, sleep, and recovery with Quantum Upgrade, a 24/7 streaming quantum energy service designed to work continuously in the background. Try it free for&nbsp;15 days&nbsp;with no credit card&nbsp;required:&nbsp;<a href="https://quantumupgrade.io/DAVE" rel="noopener noreferrer" target="_blank">https://quantumupgrade.io/DAVE</a>&nbsp;</li><li>Screenfit&nbsp;| Get your at-home eye training program for 40% off using code DAVE at&nbsp;<a href="https://www.screenfit.com/dave" rel="noopener noreferrer" target="_blank">https://www.screenfit.com/dave</a>&nbsp;</li><li>BrainTap&nbsp;| Go to&nbsp;<a href="http://braintap.com/dave" rel="noopener noreferrer" target="_blank">http://braintap.com/dave</a>&nbsp;to&nbsp;get $100 off the&nbsp;BrainTap&nbsp;Power Bundle.&nbsp;</li><li>KillSwitch&nbsp;| If&nbsp;you’re&nbsp;ready for the best sleep of your life, order now at&nbsp;<a href="https://www.switchsupplements.com/" rel="noopener noreferrer" target="_blank">https://www.switchsupplements.com</a>&nbsp;and use code DAVE for 20% off.&nbsp;</li></ul>Dave Asprey&nbsp;is a four-time New York Times bestselling author, founder of&nbsp;Bulletproof Coffee, and the&nbsp;father of biohacking. With over 1,000 interviews and 1 million monthly listeners,&nbsp;The Human Upgrade&nbsp;brings you the knowledge to take control of your biology, extend your longevity, and&nbsp;optimize&nbsp;every system in your body and mind. Each episode delivers&nbsp;cutting-edge&nbsp;insights&nbsp;in&nbsp;health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.&nbsp;New episodes are released every&nbsp;Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.&nbsp;Keywords:&nbsp;muscle longevity organ, glutes brain health, strength training longevity podcast, muscle span aging, intermuscular fat metabolism, IMAT insulin resistance, skeletal muscle brain function, neuroplasticity strength training, protein intake aging, high protein diet longevity, metabolism muscle health, mitochondria muscle brain, muscle centric medicine podcast,&nbsp;gabrielle&nbsp;lyon&nbsp;podcast, forever strong playbook, women strength training longevity, GLP-1 muscle loss, sarcopenia aging prevention, resistance training brain health, sleep optimization muscle recovery, fasting ketosis muscle health, carnivore diet muscle metabolism, functional medicine muscle health, biohacking strength longevity, human performance muscle, anti-aging strength training, supplements muscle recovery, progressive stimulus training, blood flow restriction training, muscle resilience mindset&nbsp;Resources:&nbsp;&nbsp;&nbsp;•&nbsp;Get Gabrielle’s NEW book Forever Strong:&nbsp;<a href="https://drgabriellelyon.com/forever-strong/" rel="noopener noreferrer" target="_blank">https://drgabriellelyon.com/forever-strong/</a>&nbsp;•&nbsp;Gabrielle’s Website:&nbsp;<a href="https://drgabriellelyon.com/" rel="noopener noreferrer" target="_blank">https://drgabriellelyon.com/</a>&nbsp;• Follow Gabrielle’s Instagram:&nbsp;<a href="https://www.instagram.com/drgabriellelyon/" rel="noopener noreferrer" target="_blank">https://www.instagram.com/drgabriellelyon/</a>&nbsp;• Gabrielles&nbsp;Youtube:&nbsp;<a href="https://www.youtube.com/@DrGabrielleLyon" rel="noopener noreferrer" target="_blank">https://www.youtube.com/@DrGabrielleLyon</a>&nbsp;• Get My 2026 Biohacking Trends Report:&nbsp;<a href="https://daveasprey.com/2026-biohacking-trends-report/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-biohacking-trends-report/</a>&nbsp;• Join My Low-Oxalate 30-Day Challenge:&nbsp;<a href="https://daveasprey.com/2026-low-ox-reset/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-low-ox-reset/</a>&nbsp;• Dave Asprey's Latest News | Go to&nbsp;<a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/</a>&nbsp;to&nbsp;join&nbsp;Inside Track&nbsp;today.&nbsp;&nbsp;• Danger Coffee:&nbsp;<a href="https://dangercoffee.com/discount/dave15" rel="noopener noreferrer" target="_blank">https://dangercoffee.com/discount/dave15</a>&nbsp;&nbsp;&nbsp;• My Daily Supplements:&nbsp;<a href="https://www.shopsuppgradelabs.com/discount/DAVE15" rel="noopener noreferrer" target="_blank">SuppGrade Labs</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;• Favorite Blue Light Blocking Glasses:&nbsp;<a href="https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop" rel="noopener noreferrer" target="_blank">TrueDark</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;• Dave Asprey’s BEYOND Conference:&nbsp;<a href="https://beyondconference.com/" rel="noopener noreferrer" target="_blank">https://beyondconference.com</a>&nbsp;&nbsp;&nbsp;• Dave Asprey’s New Book –&nbsp;Heavily Meditated:&nbsp;<a href="https://daveasprey.com/heavily-meditated" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated</a>&nbsp;&nbsp;• Upgrade Collective:&nbsp;<a href="https://www.ourupgradecollective.com/" rel="noopener noreferrer" target="_blank">https://www.ourupgradecollective.com</a>&nbsp;&nbsp;&nbsp;• Upgrade Labs:&nbsp;<a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a>&nbsp;&nbsp;&nbsp;&nbsp;Timestamps:&nbsp;0:00&nbsp;– Introduction&nbsp;1:01&nbsp;– The Playbook vs Workbook&nbsp;3:47&nbsp;– Protein & Metabolic Health&nbsp;6:21&nbsp;– Mindset & Negativity&nbsp;7:20&nbsp;– Histamines & Hot Flashes&nbsp;10:49&nbsp;– Women & Strength Training&nbsp;13:40&nbsp;– Connective Tissue & EDS&nbsp;16:15&nbsp;– Muscle Span & Aging&nbsp;19:41&nbsp;– Training for Kids&nbsp;21:55&nbsp;– Pain Cave & Discomfort&nbsp;25:25&nbsp;– Emotional Regulation&nbsp;29:46&nbsp;– Resilience & Dating&nbsp;32:11&nbsp;– Building Friction & Discernment&nbsp;35:47&nbsp;– Self-Denial vs Awareness&nbsp;41:03&nbsp;– Mitochondria & Energy&nbsp;42:46&nbsp;– Bigger Booty, Bigger Brain&nbsp;44:52&nbsp;– Body Fat vs IMAT&nbsp;49:01&nbsp;– Measuring Muscle Health&nbsp;52:08&nbsp;– GLP-1s & Muscle Loss&nbsp;56:12&nbsp;– Protein Absorption Myths&nbsp;59:30&nbsp;– mTOR & Protein&nbsp;1:01:29&nbsp;– Closing Thoughts&nbsp;See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.

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Your Butt is a Longevity Organ (Here’s how to train it!) | Gabrielle Lyon : 1405

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