Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback <ul> <li>Complete Revascularization for Acute MI Meta-analysis https://doi.org/10.1016/S0140-6736(25)02170-1</li> </ul> II A Sea Change in the Treatment of Carotid Artery Disease — CREST-2 Published <ul> <li>ECST-2 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00107-3/fulltext</li> <li>SPACE-2 https://pubmed.ncbi.nlm.nih.gov/36115360/</li> <li>CREST-2 Trial www.nejm.org/doi/full/10.1056/NEJMoa2508800</li> <li>CREST Protocol paper https://pmc.ncbi.nlm.nih.gov/articles/PMC5987521/</li> </ul> III Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt <ul> <li>PLATO trial https://www.nejm.org/doi/full/10.1056/NEJMoa0904327</li> <li>Ticagrelor or prasugrel vs clopidogrel in PCI https://eurointervention.pcronline.com/article/ticagrelor-or-prasugrel-versus-clopidogrel-in-patients-undergoing-percutaneous-coronary-intervention-for-chronic-coronary-syndromes</li> <li>ISAR-REACT 5 trial https://www.nejm.org/doi/full/10.1056/NEJMoa1908973</li> </ul> IV Another Coffee and AF study Can Coffee Cut the Risk for Atrial Fibrillation? https://www.medscape.com/viewarticle/can-coffee-cut-risk-atrial-fibrillation-2025a1000w11 A Coffee a Day to Keep the AFib Away? The DECAF Trial Discussed https://www.medscape.com/viewarticle/coffee-day-keep-afib-away-decaf-trial-discussed-2025a1000v5z <ul> <li>DECAF trial https://jamanetwork.com/journals/jama/fullarticle/2841253</li> </ul> You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

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Nov 21 2025 This Week in Cardiology

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