For most of human history, people went about their daily lives with a worm or two (or fifty) in their guts. Only in the past century, with pharmaceuticals and sanitation practices, have we made significant strides towards deworming the whole of humanity. And that’s typically been thought of as a good thing, because having too many worms in your body can–quite literally–suck the life out of you.
But is it possible to have… too few worms? Science wonders if deworming ourselves has actually led to an increase in certain chronic diseases. On this episode, we dive into Necator americanus, a.k.a. the American Hookworm, and its mysterious relationship with each of us.
We trace the hookworm’s 118-year journey from a demonized economic depressant, to its use as a desperate D.I.Y. immunosuppressant, to its potential as a medical treatment for a number of chronic diseases, everything from asthma to MS.
We’re bringing back two stories  from our 2009 episode <a href="https://radiolab.org/podcast/91689-parasites" rel="noopener noreferrer">Parasites</a> plus new research on hookworms and autoimmune diseases, reported by Molly Webster
Special thanks to Ethan Hein for the use of his remix of Mozart's Piano Concerto No. 21. Plus, Doris Pierce, and Dan and Alice Hadley.
EPISODE CREDITS: 
Reported by - Pat Walters and Molly Webster
 with help from - {{wREPORTERS}}
Produced by - Matt Kielty
with help from - Rebecca Rand
Fact-checking by - Diane A. Kelly
and Edited by  - Arianne Wack
EPISODE CITATIONS:
Articles - 
<a href="https://pubmed.ncbi.nlm.nih.gov/37495576/" rel="noopener noreferrer">Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes</a> (<a href="https://pubmed.ncbi.nlm.nih.gov/37495576/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/37495576/</a>) by Giacomin PR et al. Nat Commun. 2023 Jul 26
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