Dr. O'Leary explores the history of clozapine, highlighting its initial revolutionary impact as the first atypical antipsychotic, followed by a ban on its use, followed by its re-emergences as a strictly monitored medication, and then culminating in new recommendations that greatly encourage its use. The discussion details the severe side effects that led to its initial discontinuation,  and then emphasizes other critical but often overlooked adverse effects, such as metabolic syndrome, sialorrhea, and especially severe gastrointestinal hypomotility, which can be life-threatening. Please leave feedback at <a href='https://www.psydactic.com'>https://www.psydactic.com</a> or send any comments to feedback@psydactic.com. References and readings (when available) are posted at the end of each episode transcript, located at <a href='https://psydactic.buzzsprout.com'>psydactic.buzzsprout.com</a>. All opinions expressed in this podcast are exclusively those of the person speaking and should not be confused with the opinions of anyone else. We reserve the right to be wrong. Nothing in this podcast should be treated as individual medical advice.

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