TWiM describes Shigella infection is facilitated by interaction of human enteric α-defensin 5 with a colonic epithelial receptor, and an amino acid change in RNA polymerase that leads to resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism Hosts: <a href= "https://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" rel="noopener">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank" rel="noopener">Michael Schmidt</a>, <a href= "https://biology.wustl.edu/people/petra-levin" target="_blank" rel= "noopener">Petra Levin</a> and <a href= "https://medschool.umich.edu/profile/2682/michele-s-swanson" target="_blank" rel="noopener">Michele Swanson</a>. Subscribe to TWiM (free) on <a href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener">Apple Podcasts</a>, <a title= "TWiM on Google Podcasts" href= "https://open.spotify.com/show/6IFqZ6DJQ9lo4HcAOI4CeI" target= "_blank" rel="noopener noreferrer">Spotify</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> Become a <a href="http://www.microbe.tv/contribute" target= "_blank" rel="noopener">patron</a> of TWiM. Music used on TWiM is composed and performed by <a href= "http://ronaldjenkees.com/" target="_blank" rel="noopener">Ronald Jenkees</a> and used with permission. Links for this episode <ul> <li>National Black <a href= "https://www.cdc.gov/nchhstp/director-letters/national-black-hiv-aids-awareness-day-2024.html#:~:text=February%207%20is%20National%20Black,people)%20in%20the%20United%20States." target="_blank" rel="noopener">HIV/AIDS awareness day</a> (CDC)</li> <li><a href="https://www.nature.com/articles/s41564-024-01901-9" target="_blank" rel="noopener">Shigella infection and human enteric alpha-defensin 5</a> (Nature Microbio)</li> <li><a href= "https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00039-7" target="_blank" rel="noopener">RNA polymerase amino acid change and resistance to beta-lactams</a> (Cell Rep)</li> <li><a href="https://asm.org/twimpoll" target="_blank" rel= "noopener">Take the TWiM Listener surve</a><a href= "https://asm.org/twimpoll" target="_blank" rel= "noopener">y!</a></li> </ul> Send your microbiology questions and comments (email or recorded audio) to <a href= "mailto:twim@microbe.tv">twim@microbe.tv</a>

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