In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market and why people conceal their infectious diseases before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if susceptibility and disease severity are inheritable traits, if vaccination during pregnancy protects neonates or leads to adverse effects, the effectiveness of a monovalent XBB.1.5 against disease resulting from infection with Omicron variants, whether vaccination in the same or opposite arms effect antibody protection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how SARS-CoV-2 infection may alter one’s sleep patterns, what the health and economic burdens of mild disease are, and if there are predictors for recovery from fatigue and cognitive deficits following SARS-CoV-2 infection. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode <ul> <li>Do you <a href= "https://jamanetwork.com/journals/jama-health-forum/fullarticle/2814360%20https:/www.cidrap.umn.edu/covid-19/pandemic-resulted-high-healthcare-worker-turnover">want a job in</a> healthcare? (JAMA)</li> <li>Why people <a href= "https://journals.sagepub.com/doi/abs/10.1177/09567976231221990">don’t tell the truth</a> about infectious diseases (Psychological Science)</li> <li>Respiratory  <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC)</li> <li>RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a>  (CDC)</li> <li>RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC)</li> <li>Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC)</li> <li>Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC)</li> <li>COVID-19  <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC)</li> <li>COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC)</li> <li>COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot)</li> <li><a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC)</li> <li><a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC)</li> <li>Is <a href= "https://www.nature.com/articles/s41467-023-44250-7">susceptibility and severity</a> of COVID-19 inheritabile (Nat Comm)</li> <li><a href= "https://jamanetwork.com/journals/jama/fullarticle/2814537"> Neonates</a> of vaccinated mothers (JAMA)</li> <li>How is the <a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7304a2.htm?s_cid=mm7304a2_e&ACSTrackingID=USCDC_921-DM121333&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2073%2C%20February%201%2C%202024&deliveryName=USCDC_921-DM121333">monovalent XBB.1.5 vaccine</a> effectiveness against symptomatic infection  Sept 2023-Jan 2024 (MMWR)</li> <li>Second dose in the <a href= "https://www.jci.org/articles/view/176411">opposite arm</a> improves antibody response (JCI)</li> <li>Virus specific <a href= "https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00308-0/fulltext">immune repsonses</a> following contralateral or ipsilateral immunication (eBioMedicine)</li> <li><a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC)</li> <li>To rebound or to <a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a1.htm?s_cid=mm7251a1_e&ACSTrackingID=USCDC_921-DM119319&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2072%2C%20December%2022%2C%202023&deliveryName=USCDC_921-DM119319">not rebound</a> (MMWR)</li> <li><a href= "https://esmed.org/MRA/mra/article/view/3041">Know your</a> COVID-19 tools (ESMED)</li> <li><a href="https://www.paxlovid.com/paxcess">How to pay</a> for Paxlovid (PAXCESS)</li> <li>Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV)</li> <li>Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety)</li> <li>Steroids,<a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID)</li> <li><a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org)</li> <li>How COVID-19 <a href= "https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1281012/full">affected your sleep</a> (Frontiers in Public Health)</li> <li><a href= "https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03235-5"> Health and economic burden</a> of COVID-19 after illness (BMC Medicine)</li> <li><a href= "https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00035-X/fulltext"> Predicting recovery</a> from fatigue and cognitive deficits after COVID-19 (eClinical Medicine)</li> <li>Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a></li> <li><a title="" href= "https://www.microbe.tv/twiv/twiv-1086-letters/">Letters read</a> on TWiV 1086</li> <li>Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+12-21-2023.pdf">pdf</a>)</li> <li>Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks!</li> </ul> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv

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TWiV 1086: Clinical update with Dr. Daniel Griffin

This Week in Virology