Your biological age can drop by over three years in just eight weeks, and the tools to do it are already in your kitchen. This episode breaks down the&nbsp;cutting-edge&nbsp;science of methylation, polyphenols, Yamanaka mimetics, and epigenetic reprogramming that is rewriting what we know about anti-aging, longevity, and human performance.&nbsp;&nbsp;-Watch this episode on YouTube for the full video experience:&nbsp;<a href="https://www.youtube.com/@DaveAspreyBPR" rel="noopener noreferrer" target="_blank">https://www.youtube.com/@DaveAspreyBPR</a>&nbsp;Host Dave Asprey sits down with Dr. Kara Fitzgerald, ND, IFMCP, a leading voice in functional medicine and epigenetic aging research. Her award-winning clinical studies published in&nbsp;Aging&nbsp;(2021, 2023, and 2025) proved that targeted diet and lifestyle interventions can measurably reverse biological age on validated epigenetic clocks. She is the author of&nbsp;Younger You, an IFM faculty member and Certified Practitioner, and one of the most rigorously credentialed researchers working at the intersection of functional medicine, nutrition, and longevity science today.&nbsp;Together, they go deep on Yamanaka factors, the Nobel Prize-winning discovery that can wind back a 90-year-old cell to its 20s, and the emerging class of compounds called Yamanaka mimetics, polyphenol-based supplements that may replicate some of those same cellular rejuvenation effects without the risks. They cover why polyphenols do the heavy lifting in biological age reversal, how AI is accelerating longevity research, and why the dark matter of nutrition may matter more than macros, carnivore protocols, or ketosis for long-term health. They also get into oxalates, mitochondria, fibroids, ovarian rejuvenation, and why the original Horvath clock may be more relevant than scientists thought.&nbsp;This is&nbsp;essential&nbsp;listening&nbsp;for&nbsp;anyone serious about biohacking, longevity, supplements, functional medicine, anti-aging, brain optimization, human performance, and using&nbsp;smarter&nbsp;not harder strategies to take control of your biology.&nbsp;You'll&nbsp;Learn:&nbsp;<ul><li>How diet, supplements, and meditation reversed biological age by over three years in eight weeks in a randomized controlled trial&nbsp;</li><li>What Yamanaka factors are and why scientists are calling partial cellular reprogramming the future of anti-aging&nbsp;</li><li>Which polyphenols do the heaviest lifting for epigenetic rejuvenation, including EGCG, urolithin A, rosemary, marjoram, and yarrow&nbsp;</li><li>Why the Horvath epigenetic clock may&nbsp;actually be&nbsp;touching on programmatic aging rather than just&nbsp;exposomic&nbsp;wear and tear&nbsp;</li><li>How AI is unlocking patterns in longevity data that no human researcher could find alone&nbsp;</li><li>The problem with high-oxalate superfoods and how to get polyphenol benefits without the inflammatory downside&nbsp;</li><li>Why ovarian rejuvenation may be the highest-leverage Yamanaka application for women's longevity and brain health&nbsp;</li><li>How compounds like AKG, sodium butyrate, and forskolin may act as Yamanaka mimetics already available today&nbsp;</li><li>What the PRC2&nbsp;polycomb&nbsp;clock reveals about programmatic aging and why it matters more than second-generation clocks&nbsp;</li><li>Why perimenopause does not have to be painful, and how functional medicine addresses it at the root&nbsp;</li></ul>&nbsp;Thank you to our sponsors!&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;-&nbsp;Screenfit&nbsp;| Get your at-home eye training program for 40% off using code DAVE at&nbsp;<a href="https://www.screenfit.com/dave" rel="noopener noreferrer" target="_blank">https://www.screenfit.com/dave</a>.&nbsp;-&nbsp;Viome&nbsp;| Check it out at <a href="https://www.viome.com" rel="noopener noreferrer" target="_blank">viome.com</a> and use code 10DAVE for 10% off.&nbsp;It’s&nbsp;time to stop guessing and start knowing your body.&nbsp;- STEMREGEN | Go to stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order.&nbsp;- Caldera + Lab | Go to&nbsp;<a href="https://calderalab.com/DAVE" rel="noopener noreferrer" target="_blank">https://calderalab.com/DAVE</a>&nbsp;and use code DAVE at checkout for 20% off your first order.&nbsp;Dave Asprey&nbsp;is a four-time New York Times bestselling author, founder of&nbsp;Bulletproof Coffee, and the&nbsp;father of biohacking. With over 1,000 interviews and 1 million monthly listeners,&nbsp;The Human Upgrade&nbsp;brings you the knowledge to take control of your biology, extend your longevity, and&nbsp;optimize&nbsp;every system in your body and mind. Each episode delivers&nbsp;cutting-edge&nbsp;insights&nbsp;inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.&nbsp;New episodes are released every&nbsp;Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.&nbsp;Keywords:&nbsp;Kara Fitzgerald, biological age reversal, epigenetics, DNA methylation, Yamanaka factors, polyphenols, EGCG, urolithin A, anti-aging, longevity, biohacking, functional medicine, supplements, mitochondria, epigenetic clock, cellular reprogramming, AKG, sodium butyrate, methylation, Steve Horvath, Vittoria Sebastiano, coleus, perimenopause, ovarian rejuvenation, pluripotent stem cells, PRC2, dark matter of nutrition, TRIM study, dihydroxyflavone, BDNF,&nbsp;Prenuvo, chemical cellular rejuvenation&nbsp;Resources:&nbsp;&nbsp;&nbsp;•&nbsp;Learn more about all of Dr. Fitzgerald’s work at:&nbsp;<a href="https://www.drkarafitzgerald.com/" rel="noopener noreferrer" target="_blank">https://www.drkarafitzgerald.com/</a>&nbsp;• Get My 2026 Clean Nicotine Roadmap | Enroll for free at&nbsp;<a href="https://daveasprey.com/2026-clean-nicotine-roadmap/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-clean-nicotine-roadmap/</a>&nbsp;• Dave Asprey's Latest News | Go to&nbsp;<a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/</a>&nbsp;to&nbsp;join&nbsp;Inside Track&nbsp;today.&nbsp;&nbsp;• Danger Coffee:&nbsp;<a href="https://dangercoffee.com/discount/dave15" rel="noopener noreferrer" target="_blank">https://dangercoffee.com/discount/dave15</a>&nbsp;&nbsp;&nbsp;• My Daily Supplements:&nbsp;<a href="https://www.shopsuppgradelabs.com/discount/DAVE15" rel="noopener noreferrer" target="_blank">SuppGrade Labs</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;• Favorite Blue Light Blocking Glasses:&nbsp;<a href="https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop" rel="noopener noreferrer" target="_blank">TrueDark</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;• Dave Asprey’s BEYOND Conference:&nbsp;<a href="https://beyondconference.com/" rel="noopener noreferrer" target="_blank">https://beyondconference.com</a>&nbsp;&nbsp;&nbsp;• Dave Asprey’s New Book –&nbsp;Heavily Meditated:&nbsp;<a href="https://daveasprey.com/heavily-meditated" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated</a>&nbsp;&nbsp;• Join My Substack (Live Access&nbsp;To&nbsp;Podcast Recordings):&nbsp;<a href="https://substack.daveasprey.com/" rel="noopener noreferrer" target="_blank">https://substack.daveasprey.com/</a>&nbsp;• Upgrade Labs:&nbsp;<a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a>&nbsp;&nbsp;&nbsp;Timestamps:&nbsp;&nbsp;0:00 – Trailer&nbsp;1:28 – Explaining Study&nbsp;3:45 – What Is The Diet&nbsp;6:49 – Age Reversal&nbsp;8:17 – Polyphenols vs. Supplements&nbsp;9:27 – Food vs. Supplement Dosing&nbsp;12:41 – Oxalate & Polyphenol Trade-offs&nbsp;18:41 – Yamanaka Factors Explained&nbsp;28:59 – Chemical Cocktails&nbsp;32:15 – PRC2 Clocks & Programmatic Aging&nbsp;40:28 – Seasonal Eating&nbsp;43:40 – Carnivore Diet: Short vs. Long Term&nbsp;45:31 – Inuit Diet&nbsp;46:39 – Flavones & Brain-Crossing Compounds&nbsp;48:50 – Why Only Men in the Study?&nbsp;51:05 – Women, Perimenopause & the Protocol&nbsp;53:20 – Fibroids & Gaps in Women's Research&nbsp;See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.

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Eat These Foods + Spices for 8 Weeks To Get 3 Years Younger | Kara Fitzgerald : 1461

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