In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode <ul> <li>Respiratory <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC)</li> <li>RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a>  (CDC)</li> <li>RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC)</li> <li>RSV <a href= "https://www.cidrap.umn.edu/avian-influenza-bird-flu/quick-takes-good-uptake-rsv-vaccines-moms-and-infants-%20first-avian-flu-wv">vaccination stats</a> (CIDRAP)</li> <li>Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC)</li> <li>Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC)</li> <li>COVID-19  <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC)</li> <li>COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC)</li> <li>COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot)</li> <li><a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC)</li> <li><a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC)</li> <li>ACIP <a href= "https://www.cidrap.umn.edu/covid-19/cdc-advisers-recommend-spring-covid-booster-seniors">COVID vaccination for seniors</a> recommendations (CIDRAP)</li> <li>Additional vaccine doses for <a href= "https://www.cdc.gov/media/releases/2024/s-0228-covid.html">older adults</a> (CDC)</li> <li><a href= "https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2024-02-28-29/06-COVID-Wallace-508.pdf"> Evidence based advice</a> from the ACIP (CDC)</li> <li>State mandates <a href= "https://www.pnas.org/doi/abs/10.1073/pnas.2313610121">did NOT</a> influence primary vaccination rates only boosters (PNAS)</li> <li><a href= "https://www.cdc.gov/vaccines/acip/meetings/downloads/agenda-archive/agenda-2024-02-28-29-508.pdf"> No nOPV2</a>? (CDC)</li> <li><a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC)</li> <li>To rebound or to <a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a1.htm?s_cid=mm7251a1_e&ACSTrackingID=USCDC_921-DM119319&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2072%2C%20December%2022%2C%202023&deliveryName=USCDC_921-DM119319">not rebound</a> (MMWR)</li> <li><a href= "https://esmed.org/MRA/mra/article/view/3041">Know your</a> COVID-19 tools (ESMED)</li> <li><a href="https://www.paxlovid.com/paxcess">How to pay</a> for Paxlovid (PAXCESS)</li> <li>Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV)</li> <li><a href= "https://www.nature.com/articles/s41467-024-45641-0">Molunpiravir plus antibody therapy</a> for at-risk outpatients (Nat Comm)</li> <li>Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety)</li> <li>Steroids, <a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID)</li> <li><a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org)</li> <li><a href= "https://www.science.org/doi/10.1126/sciadv.adi9379">Spontaneous release</a> of IFN-g in Long COVID (Science Advances)</li> <li><a href= "https://www.nature.com/articles/s41593-024-01576-9">Blood-brain-barrier compromise</a> in long COVID associated cognitive impairment (Nat Neuroscience)</li> <li><a href= "https://www.nature.com/articles/s41586-024-07029-4">Persistent community</a> SARS-CoV-2 RNA (Nature)</li> <li><a href= "https://www.nature.com/articles/s41598-022-15565-0">Hyberbaric oxygen therapy</a> improves post COVID neurocognition (Scientific Reports)</li> <li>Medical study questionnaire, <a href= "https://www.brandeis.edu/roybal/docs/SF-36_website_PDF.pdf">the SHORT form</a> (Brandeis)</li> <li><a href= "https://www.nature.com/articles/s41598-024-53091-3">Long term effects</a> of hyperbaric oxygen post COVID (Scientific Reports)</li> <li>Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a></li> <li><a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1092-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/"> read</a> on TWiV 1092</li> <li>Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+12-21-2023.pdf">pdf</a>)</li> <li>Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks!</li> </ul> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv

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TWiV 1092: Clinical update with Dr. Daniel Griffin

This Week in Virology