Rose Byrne has taken many forms on-screen. In Mary Bronstein&rsquo;s new film <a href="https://www.fandango.com/if-i-had-legs-id-kick-you-2025-241791/movie-overview">If I Had Legs I&rsquo;d Kick You</a>, she delivers a career-defining performance as a Long Island therapist and mother slowly unraveling under the weight of her child&rsquo;s mysterious illness. &nbsp; We begin by discussing the maternal madness at the heart of this new film from A24 (6:30), the long, collaborative road to shaping the character (10:00), and what it was like to have Conan O&rsquo;Brien as a scene partner (13:30). Then, Byrne reflects on her debut performance in Dallas Doll (19:45), the plays and poems that inspired her as a teenager (22:30), and a formative role in the cult classic Two Hands, opposite the late Heath Ledger (26:00). &nbsp; In the back half, we unpack the sexism she faced in Hollywood in the aughts (32:40), her unexpected comedic breakthrough in Bridesmaids and Neighbors (37:15), and the fruitful collaborations with Seth Rogen that followed (39:50). To close, Byrne pays tribute to two of her enduring artistic influences&mdash;filmmaker David Lynch (45:00) and playwright Arthur Miller (47:00). &nbsp; Thoughts or future guest ideas? Email us at talkeasypod@gmail.com.See <a href="https://omnystudio.com/listener">omnystudio.com/listener</a> for privacy information.

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