Neurologist <a href="https://profiles.stanford.edu/michelle-monje-deisseroth">Michelle Monje</a> studies the close relationship between cancer and the nervous system, particularly in an aggressive brain cancer that often strikes in childhood. Her research shows that the cancer cells are electrically integrated into the brain itself and these connections actually help the cancer to grow. Monje and collaborators have now developed an immunotherapy that has shown great promise in mice and early human trials. One patient had a “complete response” and is cancer-free four years after treatment, Monje tells host <a href="https://profiles.stanford.edu/russ-altman">Russ Altman</a> on this episode of Stanford Engineering’s The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to <a href="mailto:thefutureofeverything@stanford.edu">thefutureofeverything@stanford.edu</a>.Episode Reference Links:<ul><li>Stanford Profile: <a href="https://profiles.stanford.edu/michelle-monje-deisseroth">Michelle Monje</a></li></ul>Connect With Us:<ul><li>Episode Transcripts >>> <a href="https://engineering.stanford.edu/magazine/collection/future-everything-podcast">The Future of Everything Website</a></li><li>Connect with Russ >>> <a href="https://www.threads.net/@russbaltman">Threads</a> / <a href="https://bsky.app/profile/rbaltman.bsky.social">Bluesky</a> / <a href="https://mastodon.social/@rbaltman">Mastodon</a></li><li>Connect with School of Engineering >>> <a href="https://twitter.com/stanfordENG">Twitter/X</a> / <a href="https://www.instagram.com/stanfordeng/">Instagram</a> / <a href="https://www.linkedin.com/school/stanford-university-school-of-engineering/posts/?feedView=all&viewAsMember=true">LinkedIn</a> / <a href="https://www.facebook.com/stanford.engineering/">Facebook</a></li></ul>Chapters:(00:00:00) IntroductionRuss Altman introduces guest Michelle Monje, a professor of pediatric neurology at Stanford University.(00:03:39) Focus on Cancer ResearchMonje’s clinical observations led to exploring cancer-neuron interactions.(00:05:28) Neurons and Glial CellsThe role of neurons and glial cells in brain function and disease.(00:08:32) Gliomas in ChildrenAn overview of gliomas and their origins in glial precursor cells.(00:10:12) Rethinking Brain Cancer BehaviorHow gliomas don’t just grow—they integrate with brain circuits.(00:14:49) Mechanisms of Tumor GrowthTwo primary mechanisms by which cancer exploits the nervous system.(00:16:32) Synaptic Integration of Cancer CellsThe discovery that glioma cells form synapses with neurons.(00:20:06) CAR T-Cell TherapyAdapting CAR T-cell immunotherapy to target brain tumors.(00:22:52) Targeting GD2 AntigenIdentification of a surface marker enables precision CAR T-cell therapy.(00:24:35) Immune Access to the BrainThe ability of CAR T-cells to reach the brain, despite prior understanding.(00:26:16) First Clinical Trial ResultsThe significant tumor reduction and response from CAR T-cell therapy.(00:28:21) Combined TherapiesPairing immune therapy with neural signaling blockers for better outcomes.(00:30:35) Conclusion
Connect With Us:Episode Transcripts >>> <a href="https://engineering.stanford.edu/magazine/collection/future-everything-podcast">The Future of Everything Website</a>Connect with Russ >>> <a href="https://www.threads.net/@russbaltman">Threads</a> / <a href="https://bsky.app/profile/rbaltman.bsky.social">Bluesky</a> / <a href="https://mastodon.social/@rbaltman">Mastodon</a>Connect with School of Engineering >>><a href="https://twitter.com/stanfordENG">Twitter/X</a> / <a href="https://www.instagram.com/stanfordeng/">Instagram</a> / <a href="https://www.linkedin.com/school/stanford-university-school-of-engineering/posts/?feedView=all&viewAsMember=true">LinkedIn</a> / <a href="https://www.facebook.com/stanford.engineering/">Facebook</a>

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