Your gray hair, thinning lashes, brain fog, and that low energy feeling after 30 might all trace back to one thing: falling NAD and stressed mitochondria. This episode breaks down what&nbsp;actually happens&nbsp;inside your cells as NAD declines, and what you can do about it using specific compounds from mushrooms, olive oil, and even chocolate.&nbsp;-Watch this episode on YouTube for the full video experience:&nbsp;<a href="https://www.youtube.com/@DaveAspreyBPR" rel="noopener noreferrer" target="_blank">https://www.youtube.com/@DaveAspreyBPR</a>&nbsp;-Grab a generous&nbsp;discount from&nbsp;Wonderfeel&nbsp;by&nbsp;going to:&nbsp;<a href="https://getwonderfeel.com/dave/" rel="noopener noreferrer" target="_blank">https://getwonderfeel.com/dave/</a>&nbsp;Host Dave Asprey sits down with Baran, CEO and co-founder of&nbsp;Wonderfeel&nbsp;Biosciences, to unpack the real science behind NAD, mitochondrial energy, and long-term longevity. Baran is an entrepreneur and inventor who previously led multiple start-ups as CEO and COO, collaborated with leading scientists and medical experts, and developed award-winning products. A UC Berkeley economics graduate and former scholarship athlete, he now focuses on translating&nbsp;cutting-edge&nbsp;bioscience into practical tools that enhance people’s lives.&nbsp;They break down how NAD powers mitochondria, why your body strategically&nbsp;allocates&nbsp;cellular energy away from peak cognitive performance as you age, and how stress accelerates that decline.&nbsp;You’ll&nbsp;hear the differences between niacinamide, NR, and NMN, the FDA confusion around NMN, and why raising NAD is about cellular repair, resilience, and metabolic function, not just “more energy.”&nbsp;The conversation goes deep on&nbsp;hydroxytyrosol, the powerful olive oil polyphenol that acts as a CD38 inhibitor, and ergothioneine, a mushroom-derived antioxidant with its own receptor in the human body that can accumulate in damaged tissues. Baran shares the origin story that pushed him to research ergothioneine, along with anecdotal observations from long-term users reporting improvements in sleep, focus, energy, thicker hair, reduced gray hair, and even eyelash regrowth.&nbsp;You’ll also hear Dave’s practical take on ketosis, fasting, supplements, and metabolism, why he prefers NAD precursors over IV NAD for most people, how methyl donors affect NAD IV tolerance, and why&nbsp;Wonderfeelbuilt a creatine chocolate bar sweetened with allulose to stay keto-friendly and diabetic-friendly. This is biohacking grounded in mechanism, from mitochondria and neuroplasticity to anti-aging strategy and smarter supplementation.&nbsp;You’ll&nbsp;Learn:&nbsp;• What NAD does in the body and why oral NAD itself is not effective&nbsp;• How niacinamide, NR, and NMN compare as NAD precursors&nbsp;• Why mitochondria control energy allocation, cognition, and resilience&nbsp;• How&nbsp;hydroxytyrosol&nbsp;may support NAD longevity through CD38 inhibition&nbsp;• What ergothioneine is, why it comes from mushrooms, and why the body has a receptor for it&nbsp;• What long-term users commonly report: better sleep, clearer thinking, stronger energy, and cosmetic shifts&nbsp;• Why Dave prefers supplements over NAD IVs in most cases&nbsp;• How allulose differs from other sweeteners and why it matters for metabolism&nbsp;• Why creatine supports brain energy and how heat changes absorption strategy&nbsp;Thank you to our sponsors!&nbsp;&nbsp;• MASA Chips | Go to&nbsp;<a href="https://www.masachips.com/DAVEASPREY" rel="noopener noreferrer" target="_blank">https://www.masachips.com/DAVEASPREY</a>&nbsp;and use code DAVEASPREY for 25% off your first order&nbsp;• Branch Basics | Get 15% off at&nbsp;<a href="https://branchbasics.com/DAVE15" rel="noopener noreferrer" target="_blank">https://branchbasics.com/DAVE15</a>&nbsp;with code DAVE15&nbsp;• ARMRA | Visit&nbsp;<a href="https://tryarmra.com/" rel="noopener noreferrer" target="_blank">https://tryarmra.com/</a>&nbsp;and use code DAVE for 15% off your first order&nbsp;•&nbsp;OneSkin&nbsp;| Try&nbsp;OneSkin&nbsp;at&nbsp;<a href="https://www.oneskin.co/DAVE" rel="noopener noreferrer" target="_blank">https://www.oneskin.co/DAVE</a>&nbsp;and use code DAVE for 15% off&nbsp;Dave Asprey&nbsp;is a four-time New York Times bestselling author, founder of&nbsp;Bulletproof Coffee, and the&nbsp;father of biohacking. With over 1,000 interviews and 1 million monthly listeners,&nbsp;The Human Upgrade&nbsp;brings you the knowledge to take control of your biology, extend your longevity, and&nbsp;optimize&nbsp;every system in your body and mind. Each episode delivers&nbsp;cutting-edge&nbsp;insights&nbsp;in&nbsp;health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.&nbsp;New episodes are released every&nbsp;Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.&nbsp;Keywords:&nbsp;NAD supplementation, NMN benefits, NR vs NMN, nicotinamide mononucleotide, mitochondrial function, CD38 inhibition,&nbsp;hydroxytyrosol&nbsp;olive oil, ergothioneine mushrooms, mushroom antioxidant benefits, Alzheimer’s prevention strategies, brain fog after 30, mitochondrial energy production,&nbsp;anti aging&nbsp;supplements, longevity compounds, fertility mitochondrial health, NAD IV vs oral NMN, creatine for brain health, allulose sweetener benefits, keto friendly chocolate, GLP 1 natural support, biohacking longevity, neuroplasticity support, metabolism optimization, fasting and NAD levels, ketosis and mitochondria, supplement regulation FDA, functional medicine longevity, Dave Asprey biohacking,&nbsp;Wonderfeel&nbsp;NMN&nbsp;Resources:&nbsp;&nbsp;&nbsp;•&nbsp;Wonderfeel&nbsp;Website:<a href="https://getwonderfeel.com/dave/" rel="noopener noreferrer" target="_blank">https://getwonderfeel.com/dave/</a>&nbsp;• Get My 2026 Biohacking Trends Report:&nbsp;<a href="https://daveasprey.com/2026-biohacking-trends-report/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-biohacking-trends-report/</a>&nbsp;• Dave Asprey's Latest News | Go to&nbsp;<a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/</a>&nbsp;to&nbsp;join&nbsp;Inside Track&nbsp;today.&nbsp;&nbsp;• Danger Coffee:&nbsp;<a href="https://dangercoffee.com/discount/dave15" rel="noopener noreferrer" target="_blank">https://dangercoffee.com/discount/dave15</a>&nbsp;&nbsp;&nbsp;• My Daily Supplements:&nbsp;<a href="https://www.shopsuppgradelabs.com/discount/DAVE15" rel="noopener noreferrer" target="_blank">SuppGrade Labs</a>&nbsp;(15% Off)&nbsp;&nbsp;• Favorite Blue Light Blocking Glasses:&nbsp;<a href="https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop" rel="noopener noreferrer" target="_blank">TrueDark</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;• Dave Asprey’s BEYOND Conference:&nbsp;<a href="https://beyondconference.com/" rel="noopener noreferrer" target="_blank">https://beyondconference.com</a>&nbsp;&nbsp;&nbsp;• Dave Asprey’s New Book –&nbsp;Heavily Meditated:&nbsp;<a href="https://daveasprey.com/heavily-meditated" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated</a>&nbsp;&nbsp;•&nbsp;Join My Substack (Live Access&nbsp;To&nbsp;Podcast Recordings):&nbsp;<a href="https://substack.daveasprey.com/" rel="noopener noreferrer" target="_blank">https://substack.daveasprey.com/</a>&nbsp;• Upgrade Labs:&nbsp;<a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a>&nbsp;&nbsp;Timestamps:&nbsp;00:00&nbsp;- Introduction&nbsp;01:13&nbsp;- What Is&nbsp;Wonderfeel&nbsp;05:31&nbsp;- NAD and NMN Explained&nbsp;09:41&nbsp;- FDA Status of NMN&nbsp;13:50&nbsp;- Supplements vs Pharmaceuticals&nbsp;16:48&nbsp;- How NAD Powers Mitochondria&nbsp;25:46&nbsp;- NAD Benefits and Effects&nbsp;30:57&nbsp;-&nbsp;Hydroxytyrosol&nbsp;35:03&nbsp;- Ergothioneine&nbsp;41:55&nbsp;- Alzheimer’s and Brain Health&nbsp;44:10&nbsp;- Vitamin D and K2&nbsp;46:15&nbsp;- Sustainable Packaging&nbsp;49:26&nbsp;- Creatine Bars&nbsp;51:43&nbsp;- Allulose Deep Dive&nbsp;59:28&nbsp;- Inflammation Research&nbsp;01:02:15&nbsp;- Supplement Regulation&nbsp;See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.

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