One possibility: a leading hypothesis pursued by researchers (and funders) was built on science that now appears to be fraudulent. Stephen Dubner speaks with the scientist and the journalist who blew the whistle.
 
<ul>
 <li>SOURCES:
 <ul>
 <li><a href="https://www.science.org/content/author/charles-piller" rel="noopener noreferrer">Charles Piller</a>, investigative journalist for Science, author of Doctored.</li>
 <li><a href="https://www.vumc.org/vmac/person/matthew-s-schrag-md-phd" rel="noopener noreferrer">Matthew Schrag</a>, associate professor of neurology at Vanderbilt University Medical Center.</li>
 </ul></li>
</ul>
 
<ul>
 <li>RESOURCES:
 <ul>
 <li><a href="https://amzn.to/4tgz7t3" rel="noopener noreferrer">Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's</a>, by Charles Piller (2025).</li>
 <li>"<a href="https://www.npr.org/sections/shots-health-news/2024/06/26/g-s1-6177/brain-waste-removal-system-amyloid-alzheimer-toxins" rel="noopener noreferrer">The brain makes a lot of waste. Now scientists think they know where it goes</a>," by Jon Hamilton (NPR, 2024).</li>
 <li>"<a href="https://www.nature.com/immersive/alzheimers-disease-history/index.html" rel="noopener noreferrer">The history of Alzheimer’s disease</a>," by Lisa Kiani and Richard Hodson (Nature, 2024).</li>
 </ul></li>
</ul>
 
<ul>
 <li>EXTRAS:
 <ul>
 <li>"<a href="https://freakonomics.com/podcast/can-marty-makary-fix-the-f-d-a/" rel="noopener noreferrer">Can Marty Makary Fix the F.D.A.?</a>" by Freakonomics Radio (2026).</li>
 <li>"<a href="https://freakonomics.com/podcast/are-you-ready-for-the-elder-swell/" rel="noopener noreferrer">Are You Ready for the Elder Swell?</a>" by Freakonomics Radio (2025).</li>
 </ul></li>
</ul> Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

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671. Why Has There Been So Little Progress on Alzheimer’s Disease?

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