Sulforaphane, Detox Pathways, and the Science of Microplastic Removal&nbsp;Microplastics are&nbsp;building up&nbsp;inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows&nbsp;actually moves&nbsp;microplastics, heavy metals, BPA, and benzene out of your&nbsp;body..&nbsp;-Watch this episode on YouTube for the full video experience:&nbsp;<a href="https://www.youtube.com/@DaveAspreyBPR" rel="noopener noreferrer" target="_blank">https://www.youtube.com/@DaveAspreyBPR</a>&nbsp;-For next week, 25% off all&nbsp;Mara&nbsp;Labs&nbsp;products when you go to&nbsp;<a href="http://www.mara-labs.com/DAVE" rel="noopener noreferrer" target="_blank">www.mara-labs.com/DAVE</a>&nbsp;and use code&nbsp;DAVE at checkout. After June 11th, the code will return to the standard 15% off.&nbsp;Host Dave Asprey sits down with Dr. John&nbsp;Gildea,&nbsp;a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of&nbsp;BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time.&nbsp;&nbsp;They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that&nbsp;won't&nbsp;break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent&nbsp;use&nbsp;compounds the benefit over time.&nbsp;You'll&nbsp;Learn:&nbsp;<ul><li>Why microplastics accumulate inside lysosomes and what sulforaphane does to release them&nbsp;</li><li>How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin&nbsp;</li><li>What an in-house study revealed about how and where microplastics&nbsp;actually leave&nbsp;the body&nbsp;</li><li>How&nbsp;toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them&nbsp;</li><li>Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch&nbsp;</li><li>How sulforaphane boosts BDNF and neuroplasticity at the cellular level&nbsp;</li><li>What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily&nbsp;</li><li>Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss&nbsp;</li><li>How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food&nbsp;</li></ul>&nbsp;Thank you to our sponsors!&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;-&nbsp;iRestore&nbsp;| Reverse hair loss at&nbsp;<a href="http://www.irestore.com/DAVE" rel="noopener noreferrer" target="_blank">www.irestore.com/DAVE</a>&nbsp;and get exclusive savings on the&nbsp;iRestore&nbsp;Elite, use code DAVE&nbsp;-&nbsp;HeartMath&nbsp;| Go to&nbsp;<a href="https://www.heartmath.com/dave" rel="noopener noreferrer" target="_blank">https://www.heartmath.com/dave</a>&nbsp;to&nbsp;save 15% off.&nbsp;- Timeline | Go to&nbsp;<a href="http://timeline.com/dave" rel="noopener noreferrer" target="_blank">timeline.com/dave</a>&nbsp;and&nbsp;you’ll&nbsp;get an&nbsp;additional&nbsp;20% off your first month&nbsp;- Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit:&nbsp;<a href="http://fromourplace.com/DAVE" rel="noopener noreferrer" target="_blank">fromourplace.com/DAVE</a>&nbsp;Use code: DAVE for 10% off sitewide&nbsp;Dave Asprey&nbsp;is a four-time New York Times bestselling author, founder of&nbsp;Bulletproof Coffee, and the&nbsp;father of biohacking. With over 1,000 interviews and 1 million monthly listeners,&nbsp;The Human Upgrade&nbsp;brings you the knowledge to take control of your biology, extend your longevity, and&nbsp;optimize&nbsp;every system in your body and mind. Each episode delivers&nbsp;cutting-edge&nbsp;insights&nbsp;inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.&nbsp;New episodes are released every&nbsp;Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.&nbsp;Keywords:&nbsp;Dr. John&nbsp;Gildea, David Roberts, Mara Labs,&nbsp;BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine,&nbsp;BerbaLite,&nbsp;ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox&nbsp;Resources:&nbsp;&nbsp;&nbsp;&nbsp;•&nbsp;For next week, 25% off all&nbsp;Mara&nbsp;Labs&nbsp;products when you go to&nbsp;<a href="http://www.mara-labs.com/DAVE" rel="noopener noreferrer" target="_blank">www.mara-labs.com/DAVE</a>&nbsp;and use code&nbsp;DAVE at checkout. After June 11th, the code will return to the standard 15% off.&nbsp;• Get My 2026 Clean Nicotine Roadmap | Enroll for free at&nbsp;<a href="https://daveasprey.com/2026-clean-nicotine-roadmap/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-clean-nicotine-roadmap/</a>&nbsp;&nbsp;• Dave Asprey's Latest News | Go to&nbsp;<a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/</a>&nbsp;to&nbsp;join&nbsp;Inside Track&nbsp;today.&nbsp;&nbsp;&nbsp;• Danger Coffee:&nbsp;<a href="https://dangercoffee.com/discount/dave15" rel="noopener noreferrer" target="_blank">https://dangercoffee.com/discount/dave15</a>&nbsp;&nbsp;&nbsp;&nbsp;• My Daily Supplements:&nbsp;<a href="https://www.shopsuppgradelabs.com/discount/DAVE15" rel="noopener noreferrer" target="_blank">SuppGrade Labs</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;&nbsp;• Favorite Blue Light Blocking Glasses:&nbsp;<a href="https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop" rel="noopener noreferrer" target="_blank">TrueDark</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;&nbsp;• Dave Asprey’s BEYOND Conference:&nbsp;<a href="https://beyondconference.com/" rel="noopener noreferrer" target="_blank">https://beyondconference.com</a>&nbsp;&nbsp;&nbsp;&nbsp;• Dave Asprey’s New Book –&nbsp;Heavily Meditated:&nbsp;<a href="https://daveasprey.com/heavily-meditated" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated</a>&nbsp;&nbsp;&nbsp;• Join My Substack (Live Access&nbsp;To&nbsp;Podcast Recordings):&nbsp;<a href="https://substack.daveasprey.com/" rel="noopener noreferrer" target="_blank">https://substack.daveasprey.com/</a>&nbsp;&nbsp;• Upgrade Labs:&nbsp;<a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a>&nbsp;&nbsp;&nbsp;&nbsp;Timestamps:&nbsp;&nbsp;0:00 – Trailer&nbsp;1:55 – Intro & Context&nbsp;4:48 – Microplastics & Sulforaphane&nbsp;12:39 – Broccoli Sprouts Formulation&nbsp;15:20 –&nbsp;Lab Origin Story&nbsp;26:01 – Reducing Toxin Exposure&nbsp;37:06 – Estrogen, Hormones & Berberine&nbsp;52:46 – Autism, ADHD & Brain Health&nbsp;59:01 – Wrap-Up&nbsp;See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.

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