In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode <ul> <li>Measles <a href= "https://www.cdc.gov/measles/cases-outbreaks.html">tracking</a> (CDC)</li> <li>Measles in <a href= "https://www.cdc.gov/measles/cases-outbreaks.html">Cook County</a> (MMWR)</li> <li><a href= "https://www.infectiousdiseaseadvisor.com/home/general-infectious-disease/measles-surge-due-to-gaps-in-routine-%20vaccination-following-covid19-pandemic/"> Gaps in measles vaccination</a> drives viral surges (Infectious Disease Advisor)</li> <li><a href= "https://www.idsociety.org/multimedia/videos/idsa-media-briefing-measles-and-misinformation-the-impact-on-public-%20health/#xd_co_f=OTBhOWYzNTktYzQwMS00MzExLWEyZTEtM2I0NWQwMjJhMWYy~"> Misinformation impacts</a> public health? Seriously? (ID Society)</li> <li>CDC alert for <a href= "https://emergency.cdc.gov/han/2024/han00504.asp">global and domestic</a> measles cases and outbreaks (CDC)</li> <li><a href= "https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.11.2400106"> Mpox</a> in Kamituga associated with outbreak in DRB (Eurosurviellance)</li> <li><a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7215a5.htm#:~:text=Discussion,1%2C000%20mpox%20cases%20occurred%20worldwide.&text=Nearly%20all%20U.S.%20mpox%20decedents%20were%20immunocompromised%20at%20the%20time%20of%20diagnosis"> Mpox in US</a>, 2023 (MMWR)</li> <li><a href= "https://reliefweb.int/report/democratic-republic-congo/la-variole-simienne-monkeypox-en-republique-democratique-du-congo-rapport-de-la-situation-epidemiologique-sitrep-no003-du-19-25-fevrier-2024?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp"> Mpox in DRC</a>, 2024 (reliefweb)</li> <li>CDC guidance for <a href= "https://www.idsociety.org/globalassets/idsa/multimedia/clinician-call-slides--qa/3-14-2024-clinician-call.pdf">respiratory diseases, COVID antiviral & emergence of clade I mpox</a> (ID Society)</li> <li><a href= "https://www.cidrap.umn.edu/mpox/more-600-dead-spreading-dr-congo-mpox-outbreak-republic-congo-reports-its-first-cases"> ~5% of infected</a> dead from mpox (CIDRAP)</li> <li><a href= "https://apnews.com/article/congo-mpox-epidemic-outbreak-disease-7c72b0efda36703155689377263d5899"> First cases of mpox</a> in Republic of Congo (AP News)</li> <li>Respiratory  <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC)</li> <li>RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a>  (CDC)</li> <li>RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC)</li> <li>Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC)</li> <li>Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC)</li> <li>COVID-19  <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC)</li> <li>COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC)</li> <li>COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot)</li> <li><a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC)</li> <li><a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC)</li> <li><a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7310a2.htm">Multisystem inflammatory</a> syndrome in children 2023 (MMWR)</li> <li>Guidance for COVID-19 in <a href= "https://academic.oup.com/jpids/advance-%20article/doi/10.1093/jpids/piad116/7604963?utm_source=etoc&utm_campaign=jpids&utm_medium=email">children and adolescents</a> (JPIDS)</li> <li><a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC)</li> <li><a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH)</li> <li>Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV)</li> <li><a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC)</li> <li><a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH)</li> <li>What do when your <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-%20assesment-hcp.html">heathcare provider </a>is infected with SARS-CoV-2 (CDC)</li> <li>Managing healthcare staffing <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html">shortages</a> (CDC)</li> <li>Steroids,<a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID)</li> <li><a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org)</li> <li><a href= "https://jamanetwork.com/journals/jama/fullarticle/2816676">High/low oxygenation target</a> (JAMA)</li> <li><a href= "https://jamanetwork.com/journals/jama/fullarticle/2816679"> How much oxygen</a> is needed (JAMA)</li> <li><a href= "https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.29486"> Orthostatic intolerance</a> in long COVID and healthy volunteers (JMV)</li> <li><a href= "https://link.springer.com/article/10.1007/s00431-024-05503-9"> Autonomic cardiac function</a> in children and adolescents with long COVID (European Journal of Pediatrics)</li> <li>Long COVID <a href= "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10907301/%20https:/www.cam.ac.uk/research/news/low-iron-%20levels-resulting-from-infection-could-be-key-trigger-of-long-covid">iron dysregulation and inflammatory stress</a> erythropoiesis (Nat Imm)</li> <li>Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a></li> <li><a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1092-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1098-letters/"> read</a> on TWiV 1098</li> <li>Dr. Griffin's COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+032224.pdf">pdf</a>)</li> <li>Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks!</li> </ul> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv

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TWiV 1098: Clinical update with Dr. Daniel Griffin

This Week in Virology