Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually&nbsp;is.&nbsp;<ul><li>Watch this episode on YouTube for the full video experience:&nbsp;<a href="https://www.youtube.com/@DaveAspreyBPR" rel="noopener noreferrer" target="_blank">https://www.youtube.com/@DaveAspreyBPR</a>&nbsp;</li><li>Get 20% off your next purchase of&nbsp;OMNi-BiOTiC&nbsp;with code ‘Dave20’ at:&nbsp;<a href="https://omnibioticlife.com/" rel="noopener noreferrer" target="_blank">https://omnibioticlife.com/</a>&nbsp;</li></ul>In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science behind GLP-1 drugs, ADHD, HRV, histamine intolerance, SIBO, and why most probiotics&nbsp;you're&nbsp;taking are&nbsp;probably dead&nbsp;before they even reach your intestines.&nbsp;Hannah Kleinfeld is the co-founder and COO of Omni-Biotic US, a Yale and Harvard graduate, and a certified health coach whose personal battle with Lyme disease drove her deep into functional medicine and microbiome science. Omni-Biotic is the number one probiotic brand in Europe, used in hospital systems alongside antibiotic treatment, and is now bringing that clinical-grade research to the US market.&nbsp;Dave and Hannah go deep on the gut-brain axis, the&nbsp;vagus&nbsp;nerve, and how dysbiosis drives everything from brain fog and poor sleep optimization to inflammation, metabolic dysfunction, and compromised mitochondria. They cover how GLP-1 drugs slow gut transit time and trigger secondary dysbiosis, why most capsule probiotics rehydrate in stomach acid and fail, how short-chain fatty acids like butyrate cross the blood-brain barrier to regulate neuroinflammation, and how your gut bacteria directly control your heart rate variability, hormones, libido, and skin. This is biohacking your biology from the inside out, and it goes far deeper than supplements and fasting.&nbsp;You'll&nbsp;Learn:&nbsp;<ul><li>Why GLP-1 drugs like Ozempic create secondary dysbiosis and what to do about it&nbsp;</li><li>How gut inflammation suppresses HRV, disrupts sleep, and accelerates aging&nbsp;</li><li>Why most probiotics rehydrate in stomach acid and never make it to your intestines&nbsp;</li><li>The gut-brain connection behind ADHD, brain fog, anxiety, and mood disorders&nbsp;</li><li>How dysbiosis sabotages weight loss by skewing Firmicutes to Bacteroidetes ratios&nbsp;</li><li>What the&nbsp;vagus&nbsp;nerve has to do with stress resilience and mitochondria health&nbsp;</li><li>How to support your microbiome through antibiotics, travel, and SIBO recovery&nbsp;</li><li>The histamine problem hiding inside popular probiotic strains&nbsp;</li><li>Why the first&nbsp;1,000 days&nbsp;of a baby's life shape lifelong immunity and HPA axis function&nbsp;</li><li>How targeted probiotic formulations are changing functional medicine&nbsp;</li></ul>Thank you to our sponsors!&nbsp;&nbsp;&nbsp;&nbsp;<ul><li>Suppgrade Labs | Grab your DAKE and Minerals 101 duo at&nbsp;<a href="http://shopsuppgradelabs.com/" rel="noopener noreferrer" target="_blank">shopsuppgradelabs.com</a>&nbsp;and use code DAVEPOD for 15% off today</li><li>Pre-order Arthur Brook's new book today at <a href="https://hub.arthurbrooks.com/meaning-of-your-life-event-registration" rel="noopener noreferrer" target="_blank">themeaningofyourlife.com</a>. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference&nbsp;</li><li>Fatty15 | Go to&nbsp;<a href="https://fatty15.com/dave" rel="noopener noreferrer" target="_blank">https://fatty15.com/dave</a>&nbsp;and save an extra $15 when you subscribe with code DAVE</li><li>BrainTap | Go to&nbsp;<a href="http://braintap.com/dave" rel="noopener noreferrer" target="_blank">http://braintap.com/dave</a>&nbsp;to get $100 off the BrainTap Power Bundle</li></ul>Dave Asprey&nbsp;is a four-time New York Times bestselling author, founder of&nbsp;Bulletproof Coffee, and the&nbsp;father of biohacking. With over 1,000 interviews and 1 million monthly listeners,&nbsp;The Human Upgrade&nbsp;brings you the knowledge to take control of your biology, extend your longevity, and&nbsp;optimize&nbsp;every system in your body and mind. Each episode delivers&nbsp;cutting-edge&nbsp;insights&nbsp;in&nbsp;health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.&nbsp;New episodes are released every&nbsp;Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.&nbsp;Keywords:&nbsp;Hannah Kleinfeld, Omni-Biotic, gut microbiome, probiotics that work, GLP-1 gut damage, Ozempic side effects, secondary dysbiosis, gut brain axis,&nbsp;vagusnerve HRV, SIBO treatment, histamine intolerance probiotics, leaky gut inflammation, butyrate blood brain barrier, ADHD gut connection, probiotic capsules vs powder, antibiotic recovery, gut skin axis, microbiome sleep, Firmicutes Bacteroidetes weight loss, functional medicine gut health&nbsp;Resources:&nbsp;&nbsp;&nbsp;•&nbsp;Get 20% off your next purchase&nbsp;of&nbsp;OMNi-BiOTiC&nbsp;with code ‘Dave20’ at:&nbsp;<a href="https://omnibioticlife.com/" rel="noopener noreferrer" target="_blank">https://omnibioticlife.com/</a>&nbsp;• Get My 2026 Clean Nicotine Roadmap | Enroll for free at&nbsp;<a href="https://daveasprey.com/2026-clean-nicotine-roadmap/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-clean-nicotine-roadmap/</a>&nbsp;• Dave Asprey's Latest News | Go to&nbsp;<a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/</a>&nbsp;to&nbsp;join&nbsp;Inside Track&nbsp;today.&nbsp;&nbsp;• Danger Coffee:&nbsp;<a href="https://dangercoffee.com/discount/dave15" rel="noopener noreferrer" target="_blank">https://dangercoffee.com/discount/dave15</a>&nbsp;&nbsp;&nbsp;• My Daily Supplements:&nbsp;<a href="https://www.shopsuppgradelabs.com/discount/DAVE15" rel="noopener noreferrer" target="_blank">SuppGrade Labs</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;• Favorite Blue Light Blocking Glasses:&nbsp;<a href="https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop" rel="noopener noreferrer" target="_blank">TrueDark</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;• Dave Asprey’s BEYOND Conference:&nbsp;<a href="https://beyondconference.com/" rel="noopener noreferrer" target="_blank">https://beyondconference.com</a>&nbsp;&nbsp;&nbsp;• Dave Asprey’s New Book –&nbsp;Heavily Meditated:&nbsp;<a href="https://daveasprey.com/heavily-meditated" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated</a>&nbsp;&nbsp;• Join My Substack (Live Access&nbsp;To&nbsp;Podcast Recordings):&nbsp;<a href="https://substack.daveasprey.com/" rel="noopener noreferrer" target="_blank">https://substack.daveasprey.com/</a>&nbsp;• Upgrade Labs:&nbsp;<a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a>&nbsp;&nbsp;&nbsp;&nbsp;Timestamps:&nbsp;00:00 - Trailer&nbsp;01:10 - Intro03:12 - Kids & Gas: Gut Imbalance in Children&nbsp;06:42 - Pills vs. Powder Probiotics&nbsp;07:28 -&nbsp;Omnibiotic&nbsp;Overview & Dave's Story&nbsp;10:44 - Probiotics & Heart Rate Variability14:14 - GLP-1 Drugs & the Microbiome&nbsp;17:24 - Gut & Sleep Quality&nbsp;19:13 - Probiotics & SIBO&nbsp;27:47 - Gut Bacteria & ADHD&nbsp;29:55 - Gut, Libido & Fertility&nbsp;36:04 - Gut & Unusual Microbiome Facts&nbsp;43:22 - Histamine Intolerance & Probiotics&nbsp;51:58 - Kids' Microbiome vs. Adults'&nbsp;56:10 - Outro&nbsp;See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.

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