Polygenic risk scores (PRS) rely on the genome-wide association studies (GWAS)
to predict the phenotype based on the genotype. However, the prediction
accuracy suffers when GWAS from one population are used to calculate PRS within
a different population, which is a problem because the majority of the GWAS
are done on cohorts of European ancestry.

In this episode, <a href="https://bbitarello.github.io/">Bárbara Bitarello</a> helps us
understand how PRS work and why they don’t transfer well across populations.

 

 
 Links:

<ul>
 <li><a href="https://www.g3journal.org/content/10/11/4027">Polygenic Scores for Height in Admixed Populations</a> (Bárbara D. Bitarello, Iain Mathieson)</li>
 <li><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008624">What is ancestry?</a> (Iain Mathieson, Aylwyn Scally)</li>
</ul>

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#56 Polygenic risk scores in admixed populations with Bárbara Bitarello

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