Dans cette 61e baladodiffusion, les Dr Luc Lanthier et Dusanka Grbic discutent de l’efficacité du resmetirom comme traitement de la stéatohépatite liée à une dysfonction métabolique, en plus de réviser la littérature médicale de janvier à mars 2024.
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Quiz clinique (2 min 32), présentation principale (2 min 56), critique (25 min 50), autres articles (33 min 00), réponse au quiz clinique (35 min 35)
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<h2>Référence principale</h2>
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Harrison SA, Bedossa P, Guy CD, Schattenberg JM, Loomba R, Taub R, et al. A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis. N Engl J Med. 2024;390(6):497-509. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38324483/">38324483</a>.
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<h3>Articles associés</h3>
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Cusi K. Selective Agonists of Thyroid Hormone Receptor Beta for the Treatment of NASH. N Engl J Med. 2024;390(6):559-561. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38324491/">38324491</a>.
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Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023;78(6):1966-86. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37363821/">37363821</a>.
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Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-835. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/36727674/">36727674</a>.
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Kanwal F, Shubrook JH, Adams LA, Pfotenhauer K, Wai-Sun Wong V, Wright E, et al. Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2021;161(5):1657-69. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/34602251/">34602251</a>.
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Byrne CD, Targher G, Tilg H. Thyroid hormone receptor-beta agonists: new MASLD therapies on the horizon. Gut. 2024;73(4):573-581. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38233199/">38233199</a>.
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Loomba R, Sanyal AJ, Kowdley KV, Bhatt DL, Alkhouri N, Frias JP, et al. Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH. N Engl J Med. 2023;389(11):998-1008. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37356033/">37356033</a>.
 
Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al; NASH CRN. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362(18):1675-85. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/20427778/">20427778</a>.
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Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena R, et al. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024;52(5):e219-e33. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38240492/">38240492</a>.
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Hammond J, Fountaine RJ, Yunis C, Fleishaker D, Almas M, Bao W, et al. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19. N Engl J Med. 2024;390(13):1186-1195. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38598573/">38598573</a>.
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<h3>Autres articles d’intérêt récent</h3>
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Healey JS, Lopes RD, Granger CB, Alings M, Rivard L, McIntyre WF, et al. Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation. N Engl J Med. 2024;390(2):107-17. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37952132/">37952132</a>.
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.Gillmore JD, Judge DP, Cappelli F, Fontana M, Garcia-Pavia P, Gibbs S, et al. Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy. N Engl J Med. 2024;390(2):132-42. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38197816/">38197816</a>.
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Glal KAM, El-Haggar SM, Abdel-Salam SM, Mostafa TM. Allopurinol Prevents Cirrhosis-Related Complications: A Quadruple Blind Placebo-Controlled Trial. Am J Med. 2024;137(1):55-64. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37832758/">37832758</a>.
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Snyder PJ, Bauer DC, Ellenberg SS, Cauley JA, Buhr KA, Bhasin S, et al. Testosterone Treatment and Fractures in Men with Hypogonadism. N Engl J Med. 2024;390(3):203-11. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38231621/">38231621</a>.
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Hong SJ, Lee SJ, Suh Y, Yun KH, Kang TS, Shin S, et al. Stopping Aspirin Within 1 Month After Stenting for Ticagrelor Monotherapy in Acute Coronary Syndrome: The T-PASS Randomized Noninferiority Trial. Circulation. 2024;149(8):562-73. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37878786/">37878786</a>.
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Albers GW, Jumaa M, Purdon B, Zaidi SF, Streib C, Shuaib A, et al. Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection. N Engl J Med. 2024;390(8):701-11. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38329148/">38329148</a>.
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Collaboration NCDRF. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;403(10431):1027-50. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38432237/">38432237</a>.
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Wood RA, Togias A, Sicherer SH, Shreffler WG, Kim EH, Jones SM, et al. Omalizumab for the Treatment of Multiple Food Allergies. N Engl J Med. 2024;390(10):889-99. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38407394/">38407394</a>.
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Chung DC, Gray DM, 2nd, Singh H, Issaka RB, Raymond VM, Eagle C, et al. A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening. N Engl J Med. 2024;390(11):973-83. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38477985/">38477985</a>.
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Imperiale TF, Porter K, Zella J, Gagrat ZD, Olson MC, Statz S, et al. Next-Generation Multitarget Stool DNA Test for Colorectal Cancer Screening. N Engl J Med. 2024;390(11):984-93. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38477986/">38477986</a>.
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<h3>Guides de pratique</h3>
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Bainey KR, Marquis-Gravel G, Belley-Cote E, Turgeon RD, Ackman ML, et al. Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology 2023 Focused Update of the Guidelines for the Use of Antiplatelet Therapy. Can J Cardiol. 2024;40(2):160-81. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38104631/">38104631</a>.
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American Diabetes Association Professional Practice Committee. Summary of Revisions: Standards of Care in Diabetes-2024. Diabetes Care. 2024 Jan 1;47(Supplement_1):S5-S10. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38078579/">38078579</a>.
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Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, et al. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2024;209(1):37-47. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37487152/">37487152</a>.
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Qadir N, Sahetya S, Munshi L, Summers C, Abrams D, Beitler J, et al. An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2024;209(1):24-36. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38032683/">38032683</a>.
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Jophlin LL, Singal AK, Bataller R, Wong RJ, Sauer BG, Terrault NA, et al. ACG Clinical Guideline: Alcohol-Associated Liver Disease. Am J Gastroenterol. 2024;119(1):30-54. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38174913/">38174913</a>.
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Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, Cronin EM, et al. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(1):e1-e156. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38033089/">38033089</a>.
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Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-S314. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38490803/">38490803</a>.
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Tenner S, Vege SS, Sheth SG, Sauer B, Yang A, Conwell DL, et al. American College of Gastroenterology Guidelines: Management of Acute Pancreatitis. Am J Gastroenterol. 2024;119(3):419-37. 
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<h3>Références du quiz clinique</h3>
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Awad K, Serban MC, Penson P, Mikhailidis DP, Toth PP, Jones SR, et al; Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. Effects of morning vs evening statin administration on lipid profile: A systematic review and meta-analysis. J Clin Lipidol. 2017;11(4):972-985. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/28826569/">28826569</a>.
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Plakogiannis R, Cohen H, Taft D. Effects of morning versus evening administration of atorvastatin in patients with hyperlipidemia. Am J Health Syst Pharm. 2005;62(23):2491-4. PubMed PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/16303904/#:~:text=Conclusion%3A%20Changes%20in%20the%20levels,day%20the%20drug%20was%20administered.">16303904</a>.

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