Two great stories of translation science leading to beneficial drugs in terrible diseases of the heart and the Sisyphean task of predicting the need for pacing after TAVI are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Sotatercept <ul> <li>HYPERION Trial https://www.nejm.org/doi/10.1056/NEJMoa2508170</li> <li>ZENITH Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415160</li> <li>Evidence report on treatment for PAH https://icer.org/news-insights/press-releases/icer-publishes-final-evidence-report-on-treatment-for-pulmonary-arterial-hypertension/</li> <li>PAH Sotatercept Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2503944</li> </ul> II Acoramidis and ATTR Cardiomyopathy <ul> <li>ATTRIBUTE-CM Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2305434?logout=true</li> <li>ATTRIBUTE-CM Analysis - Substudy https://www.jacc.org/doi/10.1016/j.jacc.2025.09.013</li> <li>Tafamadis Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1805689</li> </ul> III Pacing After TAVI <ul> <li>Prophylactic pacemaker after TAVI https://www.jacc.org/doi/10.1016/j.jacep.2025.07.028</li> <li>PROMOTE study https://doi.org/10.1016/j.hrthm.2024.12.019</li> <li>Evaluation of ESC criteria on RBBB patients undergoing TAVI https://doi.org/10.1016/j.hrthm.2024.11.030</li> <li>Editorial on Heart Rhythm journal papers https://www.heartrhythmjournal.com/article/S1547-5271(25)00114-6/abstract</li> </ul> You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Podurama

Home

Trending

Personal

Your Podcasts

New Episodes

My Files

Favourite Episodes

Tags (Folders)

Recently Played

Bookmarks

Followed Playlists

Oct 03 2025 This Week in Cardiology

This Week in Cardiology

AI Chapters

AI Insights

Reviews