CAC 0 takes a gut punch, ICD therapies cannot be surrogates for benefit, and two important trials from ESC are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I CAC 0 <ul> <li>LDL-C and CVD Risk With CAC Score 0 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf497/8228645</li> </ul> II ICD Therapies <ul> <li>Contemporary ICD Benefit https://www.jacc.org/doi/10.1016/j.jacep.2025.06.028</li> <li>PROFID Trial https://profid-project.eu/profid-ehra-trial/</li> <li>MADIT-RIT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1211107</li> <li>Declining Risk of Sudden Death in HF https://www.nejm.org/doi/full/10.1056/NEJMoa1609758</li> </ul> III Digit-HF <ul> <li>DIGIT-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415471</li> <li>Digoxin–Mortality: Comparison in the DIG trial https://academic.oup.com/eurheartj/article/40/40/3336/5520008</li> </ul> IV POTCAST <ul> <li>POTCAST trial https://www.nejm.org/doi/full/10.1056/NEJMoa2509542</li> </ul> ESC Preview IV HTN Guidelines <ul> <li>New Blood Pressure Guidelines: 4 Things I Like and 2 Concerns  https://www.medscape.com/viewarticle/new-blood-pressure-guidelines-4-thing-i-and-2-concerns-2025a1000m1x</li> </ul> You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

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Aug 29 2025 This Week in Cardiology

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