Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback <ul> <li>Meta-analysis of MI as a surrogate https://pubmed.ncbi.nlm.nih.gov/34694318/</li> <li>Compare Acute Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1701067</li> <li>DANAMI-3–PRIMULTI 10.1016/S0140-6736(15)60648-1 External Link</li> <li>CULPRIT-SHOCK https://www.nejm.org/doi/full/10.1056/NEJMoa1710261</li> <li> </li> </ul> II Huge Cardiac News for Patients with ESRD PISCES article EMBARGOED Till 1130 AM EST <ul> <li>PISCES Trial www.nejm.org/doi/full/10.1056/NEJMoa2513032</li> <li>REDUCE-IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1812792</li> <li>STRENGTH Trial https://jamanetwork.com/journals/jama/fullarticle/2773120</li> <li>FISH trial https://jamanetwork.com/journals/jama/fullarticle/1150094</li> </ul> III Obesity Agents <ul> <li>White House announces deal with Lilly and Novo on GLP-1 drugs https://www.reuters.com/business/healthcare-pharmaceuticals/novo-lilly-shares-rise-trump-obesity-drug-deal-nears-2025-11-06/</li> </ul> Amylin Agonists <ul> <li>Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial</li> </ul> https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf <ul> <li>Eloralintide Phase 2 Study https://doi.org/10.1016/S0140-6736(25)02155-5</li> </ul> GLP-1 Comparisons <ul> <li>SURMOUNT-5 Trial https://www.nejm.org/doi/10.1056/NEJMoa2416394</li> <li>Tirzepatide vs Semaglutide in 10-year CVD Risk Reduction https://doi.org/10.1093/ehjopen/oeaf117</li> </ul> IV A Problematic Trial in Stroke Care <ul> <li>LAMP trial https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2840370</li> </ul> V AHA Preview AHA 2025: Mandrola's Four Trials to Look For https://www.medscape.com/viewarticle/aha-2025-mandrolas-four-trials-look-2025a1000u80 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

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Nov 07, 2025 This Week in Cardiology

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