<p>TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine.</p> <div class="fluid-width-video-wrapper">Hosts: <a title="" href="https://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "https://medschool.umich.edu/profile/879/katherine-spindler">Kathy Spindler</a>, and <a title="" href= "https://bbarkerdrew.com/">Brianne Barker</a></div> <p>Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://backfeed.strangecode.com/GZA5raQg2EIeWv8A5Z/http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3 id="links-for-this-episode" class="wp-block-heading">Links for this episode</h3> <ul class="wp-block-list"> <li><a title="" href="https://www.microbe.tv/contribute">Support science education </a>at MicrobeTV</li> <li>Immune 100 <a title="" href= "https://www.eventbrite.com/e/immune-100-live-in-nyc-tickets-1797664816859?aff=oddtdtcreator">live at the Incubator</a></li> <li><a title="" href= "https://pmc.ncbi.nlm.nih.gov/articles/PMC431482/">Spliced segments</a> of adenovirus mRNA (PNAS)</li> <li>An <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/902310/">amazing sequence</a> in adenovirus mRNA (Cell)</li> <li>Nobel Prize for <a title="" href= "https://www.nobelprize.org/prizes/medicine/1993/press-release/">mRNA splicing</a> (Nobel)</li> <li>A <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/884734/">predominant undecanucleotide</a> in adenovirus late mRNAs (Cell)</li> <li><a title="" href= "https://www.microbe.tv/twiv/twiv-462/">Splicing RNA </a>with Phillip A. Sharp (ASM)</li> <li>Protein production in the gut by <a title="" href= "https://www.nature.com/articles/s41587-025-02570-7">engineered phage</a> (Nat Biotech)</li> <li><a title="" href= "https://doi.org/10.1016/j.coviro.2022.101255">Engineered</a> phage T4 (Curr Op Virol)</li> <li>Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a> Ramsey. Thanks!</li> </ul> <h3 class="wp-block-heading">Weekly Picks</h3> <p><strong>Brianne</strong> – <a href= "https://www.nytimes.com/interactive/2025/11/24/books/review/classic-sf-quotes.html">Can You Identify These Lines from Classic SciFi Novels?</a> <strong>Kathy</strong> –<a href= "https://www.youtube.com/watch?v=yvY61ArnxPg&list=PLkCzlk8e8aNfPZoSgvp6m-aRmY4lsUbD6&index=3&pp=iAQB"> </a><a href="https://www.youtube.com/watch?v=48A-tlOvml0&t=2354s">Saturday Morning Physics, Photograph 51</a> and <a href= "https://pubs.acs.org/doi/10.1021/ed076p378">JCE article</a> <strong>Rich</strong> – <a href= "https://en.wikipedia.org/wiki/Wikipedia:Wiki_Science_Competition_2025_in_the_United_States">Wikipedia:Wiki Science Competition 2025 in the United States</a> <strong>Jolene</strong> – <a title="" href= "https://bookdown.org/taiawu/data_viz_course/">Data visualization workshop</a> <strong>Vincent</strong> – <a href= "https://www.amazon.com/dp/B09KMPKGXK?ref=ppx_yo2ov_dt_b_fed_digi_asin_title_351">Transformer: The Deep Chemistry of Life and Death</a> by Nick Lane</p> <p>Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a></p> <p>Send your virology questions and comments to twiv@microbe.tv</p> <p>Content in this podcast should not be construed as medical advice.</p>

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