Placebos Improved IBS Symptoms Even When Patients Knew the Pills Were InactiveIn a randomized trial of 80 adults with irritable bowel syndrome, participants who knowingly took placebo pills reported greater symptom improvement than those receiving no treatment. After three weeks, 59% of the placebo group reported adequate relief compared with 35% of controls. A larger follow-up study also found that openly prescribed placebos improved reported IBS symptoms more than a no-pill control. Host Dave Asprey explores how conditioning, expectations, and the ritual of taking a treatment may influence symptoms without deception. He explains why these findings do not mean symptoms are imaginary or that positive thinking can cure disease, but raise questions about how the brain, treatment context, and learned physiological responses shape the experience of illness.Sources:<ul><li><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015591" rel="noopener noreferrer" target="_blank">PLOS ONE: Placebos Without Deception—A Randomized Controlled Trial in Irritable Bowel Syndrome</a></li><li><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8357842/" rel="noopener noreferrer" target="_blank">Pain: Open-Label Placebo vs. Double-Blind Placebo for Irritable Bowel Syndrome</a></li><li><a href="https://www.health.harvard.edu/blog/placebo-can-work-even-know-placebo-201607079926" rel="noopener noreferrer" target="_blank">Harvard Health: A Placebo Can Work Even When You Know It’s a Placebo</a></li></ul>Once-Weekly Wall Squats Preserved Some Blood-Pressure Benefits After More Frequent TrainingA randomized trial involving 100 adults found that isometric wall-squat training reduced blood pressure, with some benefits maintained after participants cut back to one or two sessions per week. The important detail is that participants first completed four weeks of training three times weekly. Those who subsequently reduced to one weekly session finished the eight-week study with systolic blood pressure approximately 6.6 mmHg below baseline, while those continuing three weekly sessions experienced the largest improvement. Host Dave Asprey explores how sustained muscle contractions may influence vascular resistance and autonomic regulation, and why the minimum dose needed to maintain a benefit can differ from the dose needed to build it. He explains why this study does not show that beginners get the same results from one weekly session or that wall squats replace medication.Sources:<ul><li><a href="https://bmjopensem.bmj.com/content/12/3/e003172" rel="noopener noreferrer" target="_blank">BMJ Open Sport & Exercise Medicine: Isometric Exercise Training and Blood Pressure Control</a></li><li><a href="https://press.psprings.co.uk/sem/september/bmjsem003172.pdf" rel="noopener noreferrer" target="_blank">Full Study: Exploring the Dose-Response to Training Frequency</a></li></ul>Expert Birdwatchers Showed Brain Differences Linked to Attention and PerceptionA study comparing 29 expert birdwatchers with 29 beginners found differences in brain structure and activity associated with bird-identification expertise. Experts showed lower mean diffusivity in regions involved in attention and perception, an MRI finding researchers interpreted as more compact tissue organization. Some differences were also present in older experts, raising questions about how sustained learning may relate to cognitive aging. Host Dave Asprey examines why birdwatching involves more than spending time outdoors: identifying unfamiliar species requires attention, visual discrimination, memory, and continued learning. He explains why these findings are interesting without proving that birdwatching prevents dementia or slows cognitive decline, since researchers cannot determine whether the hobby caused the differences or whether preexisting characteristics helped people become experts.Sources:<ul><li><a href="https://doi.org/10.1523/JNEUROSCI.1307-25.2026" rel="noopener noreferrer" target="_blank">The Journal of Neuroscience: The Tuned Cortex—Expertise-Related Structural and Functional Remodeling Across the Adult Lifespan</a></li><li><a href="https://www.eurekalert.org/news-releases/1116242" rel="noopener noreferrer" target="_blank">Society for Neuroscience: Skills From Being a Birder May Change—and Benefit—Your Brain</a></li><li><a href="https://www.bbc.com/future/article/20261019-birdwatching-rewires-the-brain-and-slows-cognitive-decline" rel="noopener noreferrer" target="_blank">BBC Future: Birdwatching Rewires the Brain and Slows Cognitive Decline</a></li></ul>Early THC Exposure Changed Serotonin Signaling in Mice Through an mTOR-Related PathwayA mouse study found that chronic THC exposure beginning early in life altered signaling through serotonin 5-HT2A receptors and increased sensitivity to a subsequently administered serotonergic drug. THC alone did not significantly disrupt the study’s baseline sensorimotor-gating measure, but previously exposed mice showed a greater disruption after the additional drug challenge. Giving rapamycin during THC exposure prevented several signaling changes and the heightened behavioral response, implicating the Akt/mTOR pathway. Host Dave Asprey explores how cannabinoid exposure may influence other neurotransmitter systems and why the timing of exposure matters when interpreting the experiment. He emphasizes that this was a mechanistic animal study, not proof that all cannabis use causes psychosis or that rapamycin can prevent cannabis-related psychiatric effects in humans.Sources:<ul><li><a href="https://pubmed.ncbi.nlm.nih.gov/29748632/" rel="noopener noreferrer" target="_blank">PubMed: Chronic Cannabis Promotes Pro-Hallucinogenic Signaling of 5-HT2A Receptors Through the Akt/mTOR Pathway</a></li><li><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6098160/" rel="noopener noreferrer" target="_blank">Neuropsychopharmacology: Full Study</a></li></ul>Pornography Consumption Was Linked to Brain Differences, but Cause and Effect Remain UnclearA brain-imaging study of 64 healthy men found that greater reported pornography consumption was associated with lower gray-matter volume in part of the right caudate, lower activation in the left putamen during a sexual-image task, and lower functional connectivity between the right caudate and a prefrontal region involved in cognitive control. Host Dave Asprey examines what these findings may suggest about reward processing, repeated exposure, and habituation while distinguishing those possibilities from claims the study did not establish. Researchers did not directly measure dopamine depletion, demonstrate brain damage, or show that pornography caused the observed differences. Because participants were assessed at one point in time, preexisting brain characteristics could also help explain differences in consumption. The study raises questions about behavior and brain biology without resolving which came first.Sources:<ul><li><a href="https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1874574" rel="noopener noreferrer" target="_blank">JAMA Psychiatry: Brain Structure and Functional Connectivity Associated With Pornography Consumption—The Brain on Porn</a></li><li><a href="https://endsexualexploitation.org/research-spotlight/the-brain-on-porn/" rel="noopener noreferrer" target="_blank">National Center on Sexual Exploitation: Research Spotlight—The Brain on Porn</a></li></ul>This episode is designed for biohackers, longevity enthusiasts, people interested in cognitive performance and cardiovascular health, and anyone trying to separate provocative brain research from proven cause and effect. Host Dave Asprey examines why placebos may improve symptoms without deception, how reduced-frequency wall-squat training can preserve some blood-pressure benefits, what expert birdwatchers reveal about learning and the aging brain, how early THC exposure altered serotonin signaling in mice, and what pornography brain-imaging research can actually establish. The larger lesson is&nbsp;evidence: distinguish symptom relief from disease treatment, maintenance from improvement, brain differences from brain damage, and a compelling animal mechanism from a proven human intervention.Keywords: open label placebo, placebo without deception, placebo effect, placebo IBS study, irritable bowel syndrome, mind body connection, conditioning and symptoms, wall squats blood pressure, wall sit exercise, isometric exercise training, minimum effective exercise dose, systolic blood pressure, vascular resistance, autonomic regulation, birdwatching brain health, birding cognitive aging, cognitive longevity, neuroplasticity, attention and memory, skill learning brain, THC brain research, cannabis serotonin signaling, cannabis psychosis research, 5-HT2A receptors, Akt mTOR pathway, rapamycin research, pornography brain study, pornography reward circuitry, caudate nucleus, brain imaging research, correlation versus causation, Dave Asprey, The Human Upgrade, biohacking research roundupThank you to our sponsors!&nbsp;&nbsp;<ul><li>Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit&nbsp;<a href="http://simplify.us/NestEgg" rel="noopener noreferrer" target="_blank">Simplify.us/NestEgg</a>&nbsp;to learn more.</li><li>Neuronic | Go to&nbsp;<a href="http://www.neuronic.online/" rel="noopener noreferrer" target="_blank">www.neuronic.online</a>&nbsp;Code DAVE for $100 off</li><li>Puori | Use my code DAVE at P-U-O-R-I dot com slash D-A-V-E for 32% off Puori Fish Oil when you start a subscription. That’s&nbsp;<a href="http://puori.com/" rel="noopener noreferrer" target="_blank">puori.com</a>&nbsp;slash DAVE, and use code DAVE at checkout.</li><li>iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at&nbsp;<a href="http://irestore.com/DAVE" rel="noopener noreferrer" target="_blank">irestore.com/DAVE</a></li></ul>Resources:&nbsp;&nbsp;&nbsp;• Get My 2026 Clean Nicotine Roadmap | Enroll for free at&nbsp;<a href="https://daveasprey.com/2026-clean-nicotine-roadmap/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-clean-nicotine-roadmap/</a>&nbsp;• Get My 2026 Biohacking Trends Report:&nbsp;<a href="https://daveasprey.com/2026-biohacking-trends-report/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-biohacking-trends-report/</a>&nbsp;• Dave Asprey's Latest News | Go to&nbsp;<a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/</a>&nbsp;to join&nbsp;Inside Track&nbsp;today.&nbsp;&nbsp;• Danger Coffee:&nbsp;<a href="https://dangercoffee.com/discount/dave15" rel="noopener noreferrer" target="_blank">https://dangercoffee.com/discount/dave15</a>&nbsp;&nbsp;&nbsp;• My Daily Supplements:&nbsp;<a href="https://www.shopsuppgradelabs.com/discount/DAVE15" rel="noopener noreferrer" target="_blank">SuppGrade Labs</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;• Favorite Blue Light Blocking Glasses:&nbsp;<a href="https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop" rel="noopener noreferrer" target="_blank">TrueDark</a>&nbsp;(15% Off)&nbsp;&nbsp;&nbsp;• Dave Asprey’s BEYOND Conference:&nbsp;<a href="https://beyondconference.com/" rel="noopener noreferrer" target="_blank">https://beyondconference.com</a>&nbsp;&nbsp;&nbsp;• Dave Asprey’s New Book –&nbsp;Heavily Meditated:&nbsp;<a href="https://daveasprey.com/heavily-meditated" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated</a>&nbsp;&nbsp;• Join My Substack (Live Access To Podcast Recordings):&nbsp;<a href="https://substack.daveasprey.com/" rel="noopener noreferrer" target="_blank">https://substack.daveasprey.com/</a>&nbsp;• Upgrade Labs:&nbsp;<a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a>&nbsp;&nbsp;See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.

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Placebo Pills, Cannabis, Wall Squats for Blood Pressure, Birdwatching, and the Porn brain : 1564

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