Disproportionality analyses are a mainstay of pharmacovigilance research, but without clear guidelines, they often lead to confusion and misinterpretation. Enter the READUS-PV statement: the first-ever guide for reporting disproportionality analyses that are replicable, reliable, and reproducible.  Tune in to find out: <ul><li>The history of reporting guidelines in pharmacovigilance and why the READUS-PV guidelines were created </li><li>Why there has been a spike in the publication of disproportionality analyses in recent years and what this means for their reliability </li><li>What it means to publish “good” pharmacovigilance science  </li></ul> Want to know more? <ul><li>Read the <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116264/'>READUS-PV guidelines</a>, <a href='https://pubmed.ncbi.nlm.nih.gov/38713346/'>why they were created</a>, and <a href='https://link.springer.com/article/10.1007/s40264-024-01441-5'>why they are important</a>. </li><li>In 2021, Khouri and colleagues showed that <a href='https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.668765/full'>current methods and models used for disproportionality analyses are unreliable</a>, and Mouffak and colleagues found that there is a <a href='https://www.sciencedirect.com/science/article/abs/pii/S0895435621002006'>tendency to overstate results in published disproportionality analyses</a>. </li><li>A book on data mining techniques in Pharmacovigilance by Poluzzi and colleagues delves deeper into this <a href='https://www.intechopen.com/chapters/38579'>exponential increase in disproportionality analyses</a>.  </li><li><a href='https://openpublishing.library.umass.edu/pare/article/id/1418/'>This paper</a> elaborates on the Delphi technique, and how it is used to gather data from reviewers to achieve scientific consensus on a problem. </li></ul>Join the conversation on social media Follow us on <a href='https://twitter.com/UMCGlobalSafety'>X</a>, <a href='https://www.linkedin.com/company/109057/'>LinkedIn</a>, or <a href='https://www.facebook.com/UppsalaMonitoringCentre'>Facebook</a> and share your thoughts about the show with the hashtag #DrugSafetyMatters. Got a story to share? We’re always looking for new content and interesting people to interview. If you have a great idea for a show, <a href='mailto:comms@who-umc.org'>get in touch</a>! About UMC Read more about <a href='https://www.who-umc.org/'>Uppsala Monitoring Centre</a> and how we work to advance medicines safety.

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#31 A guide to reporting disproportionality analyses – Michele Fusaroli and Daniele Sartori

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