In his weekly clinical update, Dr. Griffin discusses the use of monoclonal antibody therapy to prevent RSV hospitalization of infants and use of GSK’s RSV vaccine Arexy to prevent severe disease following RSV infection in adults between 50-59 years before he reviews recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if how the influenza vaccine is manufactured can reprogram the antibody response, cardiovascular consequences of influenza infection, mortality of chikungunya virus infection, if an alternative vaccination schedule impacts the anti-SARS-CoV-2 immune response, dispels the myth that increased mortality correlated with the first vaccine dose, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how manage long COVID including prevent burnout and compassion fatigue of caring for long COVID patients, whether the CDC or WHO definition of long COVID is beneficial or the use of directed questions, baselines test and listening to the patient tell their story are beneficial in making a long COVID diagnosis. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode <ul> <li><a href= "https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.6.2400046"> Nirsevimab</a> immunoprophylaxis to prevent RSV hospitalization (Eurosurveillance.)</li> <li><a href= "https://www.gsk.com/en-gb/media/press-releases/arexvy-accepted-under-priority-review-in-us-for-the-%2520prevention-of-rsv-disease-in-adults-aged-50-59-at-increased-risk/"> Arexvy</a> given Priority Review in US for the prevention of RSV disease in adults aged 50-59 (GSK)</li> <li>Respiratory  <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC)</li> <li>RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a>  (CDC)</li> <li>RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC)</li> <li><a href= "https://www.nature.com/articles/s41467-023-44551-x">Can antibodies be redirected</a> from egg adapted epitopes using recombinant or cell cultured based influenza vaccines (Nat)</li> <li>Can influenza <a href= "https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae070/7603794">infection lead to</a> cardiovascular events (JID)</li> <li><a href= "https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00739-%25209/fulltext?dgcid=raven_jbs_aip_email"> Risk of death after chikungunya infection</a> and disease (Lancet)</li> <li>Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a>(CDC)</li> <li>Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map </a>(CDC)</li> <li>COVID-19  <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC)</li> <li>COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC)</li> <li>COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot)</li> <li><a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions">Variant</a> tracker (CDC) </li> <li><a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC)</li> <li><a href= "https://www.nature.com/articles/s41467-024-45334-8">Alternative intervals</a> between vaccine doses (Nat Comm) </li> <li><a href= "https://academic.oup.com/cid/advance-%2520article/doi/10.1093/cid/ciad604/7595862?utm_source=advanceaccess&utm_campaign=cid&utm_medium=emai%2520l&nbd=40427954633&nbd_source=campaigner"> Early mortality</a> after first vaccination dose (CID)</li> <li><a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC)</li> <li>To rebound or to <a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a1.htm?s_cid=mm7251a1_e&ACSTrackingID=USCDC_921-DM119319&ACSTrackingLabel=This%2520Week%2520in%2520MMWR:%2520Vol.%252072,%2520December%252022,%25202023&deliveryName=USCDC_921-DM119319">not rebound</a> (MMWR)</li> <li><a href="https://esmed.org/MRA/mra/article/view/3041">Know your</a> COVID-19 tools (ESMED) </li> <li><a href="https://www.paxlovid.com/paxcess">How to pay</a> for Paxlovid (PAXCESS) </li> <li>Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV)</li> <li>Convalescent plasma recommendation for immunocompromised (IDSociety)</li> <li>Steroids, <a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID)</li> <li><a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org)</li> <li><a href= "https://academic.oup.com/ofid/advance-%2520article/doi/10.1093/ofid/ofae080/7603019?utm_source=advanceaccess&utm_campaign=ofid&utm_medium=e%2520mail&nbd=40427954633&nbd_source=campaigner"> Burnout compassion</a> fatigue Long COVID (OFID) </li> <li><a href= "https://jamanetwork.com/journals/jama/fullarticle/2805540">Scoring</a> PASC (JAMA) </li> <li>What is <a href= "https://www.who.int/europe/news-room/fact-sheets/item/post-covid-19-condition">your definition</a> of the Long COVID (WHO)</li> <li>Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a></li> <li><a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letters read</a> on TWiV 1088</li> <li>Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+12-21-2023.pdf">pdf</a>)</li> <li>Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks!</li> </ul> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv

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TWiV 1088: Clinical update with Dr. Daniel Griffin

This Week in Virology