Today’s guests are Priscilla Chan and Mark Zuckerberg, co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like <a class="link" href="https://cellxgene.cziscience.com">CELLxGENE</a>, <a class="link" href="https://www.biorxiv.org/content/10.1101/2025.08.18.670981v2">rbio1</a>, <a class="link" href="https://www.biorxiv.org/content/10.1101/2025.10.31.685862v1">VariantFormer</a>, and many more. We talked about the evolution from a broad philanthropic institute to specializing in frontier AI + bio, why they are building 12ft tall microscopes to gather better data, and how building a virtual cell model + virtual immune system could potentially help us cure all diseases. <h3>Chapters</h3><ul><li>00:00:00 Introduction and CZI's 10-Year Anniversary</li><li>00:00:56 Learning from Bill Gates</li><li>00:04:05 Science vs Translation</li><li>00:10:45 The Power of Physical Proximity in Science</li><li>00:13:55 Building the Virtual Cell: From Data to Models</li><li>00:15:51 Microscopes, Imaging, and Converting Atoms to Bits</li><li>00:23:18 AI Meets Biology: The Frontier Lab Concept</li><li>00:27:25 How Models Can Enable More Ambitious Research</li><li>00:30:15 Precision Medicine and Clinical Impact</li><li>00:45:17 The Virtual Immune System and Cellular Engineering</li><li>00:48:27 Accelerating the Timeline: What It Takes to Cure All Disease</li><li>00:28:45 Joining Forces with Evolutionary Scale</li></ul>

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Priscilla Chan and Mark Zuckerberg: Frontier AI + Virtual Biology To Solve All Diseases

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