Fix Leaky Gut, Boost Testosterone & Slash Endotoxins with Spore-Based Probiotics | Kiran KrishnanYour bad gut bacteria might be the reason your testosterone, your immune system, and even your sperm count are struggling, and most probiotics never survive long enough to fix it. This episode reveals which strains actually make it through your stomach acid alive, and what happens once they do.&nbsp;&nbsp;Go To <a href="https://get.justthrivehealth.com/pages/asprey" rel="noopener noreferrer" target="_blank">JustThriveHealth.com/asprey</a> for a free 90 day supply of bitters with&nbsp;your next subscription.&nbsp;Host Dave Asprey sits down with research microbiologist Kiran Krishnan, co-founder of Microbiome Labs, the leading microbiome therapeutics brand among healthcare professionals. He has published multiple peer-reviewed studies, holds global patents, and has spent 20 years building companies focused on the science of the microbiome. His work centers on spore-based probiotics, the rare strains proven to survive the stomach's brutal acidity and actually rebuild the gut from the inside out.&nbsp;Kiran and Dave break down why 98 percent of conventional probiotics die before they ever reach your gut, and why spore-forming bacteria are different. They dig into the "gelding effect," the well-documented pathway where endotoxins from bad gut bacteria shut down testosterone production and drive up cortisol, and how fixing your microbiome can reverse it. They cover the connection between endotoxemia and nearly every major marker of aging, metabolism, and inflammation, why butyrate acts like a natural GLP-1 for fat loss, how Akkermansia can upregulate mitochondria and improve blood sugar control, and the surprising role vitamin K2 plays in bone density and functional medicine. This is biohacking at the cellular level, using ancient biology, fasting-adjacent metabolic pathways, and precision supplementation to optimize human performance from the gut up.&nbsp;You'll Learn:&nbsp;<ul><li>Why 98 percent of probiotics die in your stomach before they ever work&nbsp;</li><li>What the "gelding effect" is and how gut bacteria can shut down testosterone&nbsp;</li><li>How endotoxins drive inflammation, cortisol, and accelerated aging&nbsp;</li><li>Why butyrate functions like a natural, low-cost alternative to GLP-1 drugs&nbsp;</li><li>How Akkermansia improves mitochondrial function and blood sugar control&nbsp;</li><li>The overlooked link between your microbiome and vitamin K2 production&nbsp;</li><li>Why spore-based probiotics can survive gastric acid when most others cannot&nbsp;</li><li>How 90 days of gut repair can measurably reduce circulating endotoxins&nbsp;</li></ul>&nbsp;Keywords: best probiotics that survive stomach acid, spore based probiotics benefits, gelding effect testosterone, endotoxins and testosterone, how to lower endotoxins, LPS gut bacteria, Akkermansia GLP-1 natural, gut bacteria and belly fat, vitamin K2 bone density, Kiran Krishnan microbiologist, Just Thrive probiotic, leaky gut symptoms, microbiome and testosterone, fecal transplant benefits, Dave Asprey, biohacking, longevity&nbsp;Resources:&nbsp;&nbsp;&nbsp;• Go To <a href="https://get.justthrivehealth.com/pages/asprey?utm_source=asprey&utm_medium=podcast&utm_campaign=asprey-podcast-host-read" rel="noopener noreferrer" target="_blank">JustThriveHealth.com/asprey</a> for a free 90 day supply of bitters with&nbsp;your next subscription&nbsp;• Learn More About All Of Just Thrive’s Offerings At: <a href="https://justthrivehealth.com/" rel="noopener noreferrer" target="_blank">https://justthrivehealth.com/</a>&nbsp;• Get My 2026 Clean Nicotine Roadmap | Enroll for free at <a href="https://daveasprey.com/2026-clean-nicotine-roadmap/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-clean-nicotine-roadmap/</a>&nbsp;&nbsp;• Dave Asprey's Latest News | Go to <a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/</a> to join Inside Track today.&nbsp;&nbsp;&nbsp;• Danger Coffee: <a href="https://dangercoffee.com/discount/dave15?" rel="noopener noreferrer" target="_blank">https://dangercoffee.com/discount/dave15?</a>&nbsp;• My Daily Supplements: <a href="https://www.shopsuppgradelabs.com/discount/DAVE15" rel="noopener noreferrer" target="_blank">SuppGrade Labs</a> (15% Off)&nbsp;&nbsp;&nbsp;&nbsp;• Favorite Blue Light Blocking Glasses: <a href="https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop" rel="noopener noreferrer" target="_blank">TrueDark</a> (15% Off)&nbsp;&nbsp;&nbsp;&nbsp;• Dave Asprey’s BEYOND Conference: <a href="https://beyondconference.com/" rel="noopener noreferrer" target="_blank">https://beyondconference.com</a>&nbsp;&nbsp;&nbsp;&nbsp;• Dave Asprey’s New Book – Heavily Meditated: <a href="https://daveasprey.com/heavily-meditated" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated</a>&nbsp;&nbsp;&nbsp;• Join My Substack (Live Access To Podcast Recordings): <a href="https://substack.daveasprey.com/" rel="noopener noreferrer" target="_blank">https://substack.daveasprey.com/</a>&nbsp;&nbsp;• Upgrade Labs: <a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a>&nbsp;&nbsp;&nbsp;&nbsp;Thank you to our sponsors!&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;- ZenBud | Dave’s Nervous System Biohack. Visit <a href="https://zenbud.health/" rel="noopener noreferrer" target="_blank">zenbud.health</a> and use code DAVE15 at checkout for a discount.&nbsp;- BodyHealth | Visit <a href="https://bodyhealth.com/" rel="noopener noreferrer" target="_blank">BodyHealth.com</a> and use code DAVE20 for 20% off your first purchase.&nbsp;- Redmond Real - Leaf Toothpaste | Go to&nbsp;<a href="https://redmond.com/asprey" rel="noopener noreferrer" target="_blank">https://redmond.com/asprey</a>&nbsp;and use code ASPREY for 15% off your first order.&nbsp;- Show notes - ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit <a href="https://fastestchange.com/" rel="noopener noreferrer" target="_blank">FastestChange.com</a>&nbsp;Timestamps:&nbsp;&nbsp;00:00 – Trailer&nbsp;00:38 – Kiran Intro&nbsp;02:01 – Stomach Acid & Probiotics&nbsp;05:25 – Fauci & Spore Bacteria&nbsp;13:58 – Losing Gut Diversity&nbsp;19:01 – How Butyrate Is Made&nbsp;22:11 – Dave's Personal Stack&nbsp;24:00 – Quorum Sensing&nbsp;31:26 – Endotoxins Explained&nbsp;37:13 – Charcoal & Binders&nbsp;39:41 – SIBO & Gut Bacteria&nbsp;45:03 – Discovering Vitamin K2&nbsp;49:33 – Gelding Effect & Testosterone&nbsp;54:51 – Akkermansia & Weight Loss&nbsp;01:02:17 – Role of Bitters&nbsp;01:04:47 – Just Thrive Gift&nbsp;See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.

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