Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design. Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a> and <a title="" href= "https://mgm.ufl.edu/profile/condit-rich/">Rich Condit</a> Guest: <a title="" href= "https://molecularbiosci.utexas.edu/directory/jason-mclellan">Jason McLellan</a> Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode <ul> <li><a href="https://discord.gg/xA4JX7AeeU">MicrobeTV Discord Server</a></li> <li>MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a></li> <li>Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>)</li> <li><a title="" href="http://www.despommier.com/">The New City</a> by Dickson Despommier</li> <li><a title="" href= "http://prefusion-stabilized%20sars-cov-2%20spikes/">Prefusion-stabilized</a> SARS-CoV-2 spikes (Science)</li> <li>Structure-based <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/35598506/">vaccine design</a> (Curr Opin Immunol)</li> <li>Prefusion-stabilized SARS-CoV-2 <a title="" href= "https://www.nature.com/articles/s41467-024-45404-x">S2-only antigen</a> (Nat Comm)</li> <li>Stabilized <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/34710354/">coronavirus spike stem</a> elicits broadly protective antibody (Cell Rep)</li> <li>Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks!</li> </ul> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv

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TWiV 1103: Jason 'Spike' McLellan

This Week in Virology