Imprinting is a quirk of the immune system in which someone’s initial exposure to a virus biases their immune response when they meet the same virus again.Studies are showing how imprinting shapes people’s responses to SARS-CoV-2; those infected with earlier strains can mount weaker responses to a later Omicron infection.This phenomenon is dampening the hope that variant-tailored boosters will markedly reduce transmission of the virus, although researchers agree that variant-tailored boosters are worth getting because they still provide some immunity, and prevent serious illness.This is an audio version of our Feature: <a href="https://www.nature.com/articles/d41586-023-00086-1" rel="noopener noreferrer" target="_blank">How your first brush with COVID warps your immunity</a><hr> Hosted on Acast. See <a style='color:grey;' target='_blank' rel='noopener noreferrer' href='https://acast.com/privacy'>acast.com/privacy</a> for more information.

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Audio long read: How your first brush with COVID warps your immunity

Nature Podcast