In his weekly clinical update, Dr. Griffin and Vincent Racaniello wish everyone a Happy Thanksgiving and then decry appointment of the Louisiana State surgeon general as deputy chief of the CDC, the 3 children's deaths during this fall's pertussis outbreak, the Marburg virus outbreak in Ethiopia, results of the phase 1 safety trial for the novel poliovirus vaccines nOPV1 and nOPV3, and the first human death from H5N5 influenza virus infection in the US this fall, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, effectiveness of the cell or egg based flu or the mRNA vaccines, immunogenicity and efficacy of updated COVID-19 vaccines, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, immune and cognitive dysfunction during long COVID and contacting your federal government representative to stop the assault on science and biomedical research. <div class="fluid-width-video-wrapper">Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065">Apple Podcasts</a>, <a href= "https://backfeed.strangecode.com/GZA5raQg2EIeWv8A5Z/http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></div> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! <h3 id="links-for-this-episode" class="wp-block-heading"> Links for this episode</h3> <ul class="wp-block-list"> <li>Anti-science Movement: <a href= "https://x.com/la_surgeon/status/1970272876436631778">Deputy director</a> of CDC (X:Louisiana Office of the Surgeon General)</li> <li>CDC's new deputy director is <a href= "https://www.cidrap.umn.edu/public-health/cdc-s-new-deputy-director-vocal-critic-vaccines-advocated-ivermectin">vocal critic</a> of vaccines, advocated for ivermectin (CIDRAP)</li> <li>Whooping cough cases on the <a href= "https://www.fox4news.com/news/whooping-cough-cases-rise-texas">rise in Texas</a> (FOX4: KDFW)</li> <li>Third infant in Kentucky <a href= "https://www.cidrap.umn.edu/pertussis/third-infant-kentucky-dies-whooping-cough-national-cases-stay-high-second-year-row">dies of whooping cough</a> as national cases stay high for second year in a row (CIDRAP)</li> <li>More than <a href= "https://abcnews.go.com/Health/25000-cases-whooping-cough-recorded-year-higher-pre/story?id=127831021">25,000 whooping cough cases</a> reported this year as Kentucky records 3rd infant death (ABC News)</li> <li>Vaccination <a href= "https://www.cdc.gov/schoolvaxview/data/index.html">Coverage and Exemptions</a> among Kindergartners (CDC: SchoolVaxView)</li> <li>Effects of human papillomavirus (HPV) <a href= "https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015363.pub2/full?utm_source=25&CampaignID=987&interactionId=bSTcCRTKQrWoXfzON1TJ9sV20dImQFd-GA5lfvaKtuYydcnhYi5_EQ%3D%3D">vaccination programmes</a> on community rates of HPV‐related disease and harms from vaccination (Cochrane Library)</li> <li>Marburg <a href= "https://www.cdc.gov/marburg/situation-summary/index.html">Outbreak in Ethiopia</a>: Current Situation (CDC: Marburg Virus Disease)</li> <li>Safety and immunogenicity of <a href= "https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2825%2900285-3/fulltext?dgcid=raven_jbs_etoc_email">novel live attenuated type 1 and type 3 oral poliomyelitis vaccines</a> in healthy adults in the USA: a first-in-human, observer-masked, multicentre, phase 1 randomised controlled trial (LANCET: Infectious Diseases)</li> <li>Washington state resident believed to be the first to die from a <a href= "https://apnews.com/article/bird-flu-infection-washington-h5n5-c8148b46cf9cc8a4f1e5562923086298">rare strain of bird flu</a> (AP News)</li> <li><a href= "https://data.wastewaterscan.org/tracker/?charts=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%3D&selectedChartId=668c22"> Wastewater</a> for measles (WasterWater Scan)</li> <li>Measles <a href= "https://www.cdc.gov/measles/data-research/index.html">cases and outbreaks</a> (CDC Rubeola)</li> <li>Tracking <a href= "https://publichealth.jhu.edu/ivac/resources/us-measles-tracker">Measles Cases</a> in the U.S. (Johns Hopkins)</li> <li>Measles vaccine recommendations from NYP (<a href= "https://b2927012.smushcdn.com/2927012/wp-content/uploads/sites/2/measles_vax_rec_2.png?lossy=2&strip=1&webp=1">jpg</a>)</li> <li><a href= "https://health-infobase.canada.ca/measles-rubella/">Weekly</a> measles and rubella monitoring (Government of Canada)</li> <li><a href= "https://www.who.int/news-room/fact-sheets/detail/measles">Measles</a> (WHO)</li> <li>Get the <a href= "https://www.health.ny.gov/diseases/communicable/measles/">FACTS</a> about measles (NY State Department of Health)</li> <li><a href= "https://www.cdc.gov/measles/hcp/vaccine-considerations/index.html"> Measles</a> (CDC Measles (Rubeola))</li> <li><a href= "https://www.cdc.gov/measles/index.html">Measles</a> vaccine (CDC Measles (Rubeola))</li> <li><a href= "https://fda-my.sharepoint.com/Users/Amy/Desktop/Measles%20(CDC%20Measles%20(Rubeola))"> Presumptive evidence</a> of measles immunity (CDC)</li> <li><a href= "https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-13-measles.html#cdc_report_pub_study_section_9-contraindications-and-precautions-to-vaccination"> Contraindications and precautions</a> to measles vaccination (CDC)</li> <li>Adverse events associated with <a href= "https://www.ncbi.nlm.nih.gov/books/NBK236284/#:~:text=The%20evidence%20favors%20acceptance%20of,in%20temporal%20relation%20to%20vaccination">childhood vaccines</a>: evidence bearing on causality (NLM)</li> <li>Measles <a href= "https://www.idsociety.org/public-health/measles/know-the-facts/">Vaccination:</a> Know the Facts (ISDA: Infectious Diseases Society of America)</li> <li>Deaths following vaccination: what does the <a href= "https://www.sciencedirect.com/science/article/abs/pii/S0264410X15006556?via%3Dihub">evidence show</a> (Vaccine)</li> <li>Influenza: Waste water scan for <a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0xOIoBBmQ0MzllMsABAQ%3D%3D&selectedChartId=d439e2">11 pathogens</a> (WastewaterSCan)</li> <li>US<a href= "https://www.cdc.gov/respiratory-viruses/data/activity-levels.html"> respiratory</a> virus activity (CDC Respiratory Illnesses)</li> <li>Respiratory virus <a href= "https://www.cdc.gov/respiratory-viruses/data/activity-levels.html">activity</a> levels (CDC Respiratory Illnesses)</li> <li>Weekly surveillance report: <a href= "https://www.cdc.gov/fluview/surveillance/2024-week-37.html">clift notes</a> (CDC FluView)</li> <li>Superior Effectiveness and Estimated Public Health Impact of <a href= "https://link.springer.com/article/10.1007/s40121-025-01230-2#xd_co_f=ZTI1MjMzZjktZDBmMi00NGY4LWFhMzctYTVkY2EyZmVmN2My~">Cell- Versus Egg</a>-Based Influenza Vaccines in Children and Adults During the US 2023–2024 Season (Infectious Diseases and Therapy)</li> <li>Efficacy, Immunogenicity, and Safety of <a href= "https://www.nejm.org/doi/10.1056/NEJMoa2416779?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed">Modified mRNA</a> Influenza Vaccine(NEJM)</li> <li><a href= "https://www.cdc.gov/flu/hcp/acip/index.html">ACIP</a> Recommendations Summary (CDC: Influenza)</li> <li><a href= "https://www.cdc.gov/flu/about/viruses-types.html">Types</a> of Influenza Viruses (CDC: Influenza (flu))</li> <li>Influenza Vaccine Composition for the <a href= "https://www.fda.gov/vaccines-blood-biologics/influenza-vaccine-composition-2025-2026-us-influenza-season?mtm_source=25">2025-2026</a> U.S. Influenza Season (FDA)</li> <li>RSV: Waste water scan for <a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0xOIoBBmQ0MzllMsABAQ%3D%3D&selectedChartId=d439e2">11 pathogens</a> (WastewaterSCan)</li> <li><a href= "https://www.pophive.org/respiratory-diseases/respiratory-syncytial-virus"> Respiratory Diseases</a> (Yale School of Public Health)</li> <li>US<a href= "https://www.cdc.gov/respiratory-viruses/data/activity-levels.html"> respiratory</a> virus activity (CDC Respiratory Illnesses)</li> <li>RSV-<a href= "https://www.cdc.gov/rsv/php/surveillance/rsv-net.html">Net</a>work (CDC Respiratory Syncytial virus Infection)</li> <li><a href= "https://www.cdc.gov/rsv/vaccines/adults.html">Vaccines for Adults</a> (CDC: Respiratory Syncytial Virus Infection (RSV))</li> <li><a href= "https://www.cdc.gov/acip/downloads/slides-2025-04-15-16/04-Ortega-Sanchez-Adult-RSV-508.pdf"> Economic Analysis</a> of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)</li> <li>Estimating <a href= "https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf621/8322890">Risk</a> of Guillain-Barré Syndrome in US Medicare-Enrolled Older Adults Following Medically Attended Respiratory Syncytial Virus Disease (CID)</li> <li><a href= "https://www.fda.gov/safety/medical-product-safety-information/fda-requires-guillain-barre-syndrome-gbs-warning-prescribing-information-rsv-vaccines-abrysvo-and"> FDA Requires</a> Guillain-Barré Syndrome (GBS) Warning in the Prescribing Information for RSV Vaccines Abrysvo and Arexvy: FDA Safety Communication (FDA)</li> <li>Brag Sets Off a Chain Reaction — Dr. Oz Takes the Bait, But <a href= "https://atlantablackstar.com/2025/11/02/trumps-absurd-brag-sets-off-a-chain-reaction-dr-oz-takes-the-bait-but-fumbles-the-math-and-starts-unraveling-mid-interview/">Fumbles</a> the Math, and Starts Unraveling Mid-Interview (Atlanta BlackStar)</li> <li>Waste water scan for <a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0xOIoBBmQ0MzllMsABAQ%3D%3D&selectedChartId=d439e2">11 pathogens</a> (WastewaterSCan)</li> <li>COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#maps_percent-covid-deaths">deaths</a> (CDC)</li> <li>Respiratory Illnesses <a href= "https://www.cdc.gov/respiratory-viruses/data/index.html">Data Channel</a> (CDC: Respiratory Illnesses)</li> <li>COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national and regional</a> trends (CDC)</li> <li>COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/index.html#variant-proportions">variant tracker</a> (CDC)</li> <li>SARS-CoV-2 <a href= "https://nextstrain.org/ncov/gisaid/global/all-time?d=tree,frequencies&p=full&r=division&showBranchLabels=all&tl=none">genomes</a> galore (Nextstrain)</li> <li>Antigenic and Virological Characteristics of SARS-CoV-2 Variant <a href= "https://www.biorxiv.org/content/10.1101/2025.04.30.651462v1.full.pdf">BA.3.2, XFG, and NB.1.8.1</a> (bioRxiV)</li> <li>Effectiveness of the <a href= "https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2825%2900380-9/fulltext?dgcid=raven_jbs_etoc_email">BNT162b2 and mRNA-1273 JN.1-adapted vaccines</a> against COVID-19-associated hospitalisation and death: a Danish, nationwide, register-based, cohort study (LANCET: Infectious Diseases)</li> <li>Immunogenicity of <a href= "https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaf705/8327161?utm_source=advanceaccess&utm_campaign=ofid&utm_medium=email">JN.1- and KP.2-Encoding mRNA COVID-19 Vaccines</a> Against JN.1 Subvariants in Adult Participants (OFID)</li> <li>SARS-CoV-2 vaccination and <a href= "https://academic.oup.com/rheumatology/advance-article/doi/10.1093/rheumatology/keaf609/8340427">myositis</a> in Norway and Sweden (Rheumatology)</li> <li><a href= "https://www.pemgarda.com/hcp/infusion-center-locator/">Where</a> to get pemgarda (Pemgarda)</li> <li><a href= "https://investors.adagiotx.com/news-releases/news-release-details/invivyd-announces-fda-authorization-emergency-use-pemgardatm"> EUA</a> for the pre-exposure prophylaxis of COVID-19 (INVIYD)</li> <li>Infusion <a href= "https://primeinfusions.com/locations/">center</a> (Prime Fusions)</li> <li><a href= "https://www.cdc.gov/respiratory-viruses/guidance/faqs.html?CDC_AAref_Val=https://www.cdc.gov/respiratory-viruses/guidance/faq.html"> CDC Quarantine</a> guidelines (CDC)</li> <li><a href= "https://www.ncbi.nlm.nih.gov/books/NBK570371/">NIH</a> COVID-19 treatment guidelines (NIH)</li> <li>Drug interaction <a href= "https://covid19-druginteractions.org/checker">checker</a> (University of Liverpool)</li> <li>Help your eligible <a href= "https://paxlovid.pfizerpro.com/access-resources/access">patients access</a> PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro)</li> <li>Understanding<a href= "https://paxlovid.iassist.com/"> Coverage</a> Options (PAXCESS)</li> <li><a href= "https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/#ExecutiveSummaryandBackground"> Infectious Disease Society guidelines</a> for treatment and management (ID Society)</li> <li>Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV)</li> <li>Convalescent plasma recommendation for <a href= "https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/">immunocompromised</a> (ID Society)</li> <li>What to do when sick with a <a href= "https://www.cdc.gov/ncird/whats-new/updated-respiratory-virus-guidance.html">respiratory virus</a> (CDC)</li> <li>Managing healthcare staffing <a href= "https://www.cdc.gov/covid/hcp/infection-control/mitigating-staff-shortages.html?CDC_AAref_Val=https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html">shortages</a> (CDC)</li> <li><a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org)</li> <li>Daniel Griffin's <a href= "https://academic.oup.com/ofid/article/11/9/ofae462/7733485">evidence based</a> medical practices for long COVID (OFID)</li> <li>Long COVID <a href= "https://www.columbiadoctors.org/health-library/article/long-covid/">hotline</a> (Columbia : Columbia University Irving Medical Center)</li> <li><a href="https://longcovidtheanswers.com/">The answers:</a> Long COVID</li> <li>Digitally Assessed <a href= "https://academic.oup.com/ofid/article/12/11/ofaf447/8324890?utm_source=advanceaccess&utm_campaign=ofid&utm_medium=email#google_vignette">Long COVID Symptomatology</a> Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential (OFID)</li> <li>Evaluation of Interventions for <a href= "https://jamanetwork.com/journals/jamaneurology/fullarticle/2841155?utm_source=25&CampaignID=987&interactionId=bSTcCRTKQrWoXfzON1TJ9sV20dImQFd-GA5lfvaKtuYydcnhYi5_EQ%3D%3D">Cognitive Symptoms</a> in Long COVID (JAMA Neurology)</li> <li>Reaching out to <a href= "https://www.house.gov/representatives/find-your-representative">US house representative</a></li> <li><a title="" href= "https://www.microbe.tv/twiv/twiv-1274-letters/">Letters read</a> on TWiV 1274</li> <li>Dr. Griffin's COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+032224.pdf">pdf</a>)</li> <li>Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene Ramsey</a>. Thanks!</li> </ul> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.

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