Serious and unexpected adverse drug reactions – the ‘black swans’ of pharmacovigilance – can place enormous strain on safety monitoring systems. Drawing examples from the COVID-19 pandemic, François Montastruc from Toulouse University Hospital explains how we can get better at dealing with the unexpected.Tune in to find out:<ul><li>What Nassim Nicholas Taleb’s ‘black swan’ theory has to do with pharmacovigilance</li><li>What makes an adverse drug reaction a black, white, or grey swan</li><li> Why flexibility and communication are key to patient safety</li></ul>Want to know more? Here are the research articles cited in the episode:<ul><li><a href='https://bmjmedicine.bmj.com/content/2/1/e000352'>Quality of reporting of adverse events in clinical trials</a> of COVID-19 drugs: systematic review</li><li><a href='https://link.springer.com/article/10.1007/s40264-020-01013-3'>Psychiatric disorders and hydroxychloroquine</a> for COVID-19: a VigiBase study</li><li><a href='https://www.sciencedirect.com/science/article/abs/pii/S1542356520310600?via%3Dihub'>Hepatic disorders with the use of remdesivir</a> for COVID-19</li><li><a href='https://www.sciencedirect.com/science/article/pii/S1198743X2100094X?via%3Dihub'>Serious bradycardia and remdesivir</a> for COVID-19: a new safety concern</li><li><a href='https://www.sciencedirect.com/science/article/abs/pii/S235255682100093X?via%3Dihub'>Oxford-AstraZeneca COVID-19 vaccine-induced cerebral venous thrombosis and thrombocytopaenia:</a> a missed opportunity for a rapid return of experience</li><li><a href='https://www.sciencedirect.com/science/article/abs/pii/S004059572100130X?via%3Dihub'>Atypical thrombosis associated with VaxZevria® (AstraZeneca) vaccine:</a> data from the French network of regional pharmacovigilance centres</li><li><a href='https://www.sciencedirect.com/science/article/abs/pii/S0040595724000015?via%3Dihub'>Teaching pharmacovigilance to French medical students</a> during the COVID-19 pandemic: interest of distance learning clinical reasoning sessions</li></ul>If you enjoyed this podcast, check out these related episodes from the Drug Safety Matters archive:<ul><li><a href='https://www.drugsafetymatterspod.org/618871/12805441'>Reforming pharmacovigilance education</a></li><li><a href='https://www.drugsafetymatterspod.org/618871/11863934'>Lessons in pandemic pharmacovigilance</a></li><li><a href='https://www.drugsafetymatterspod.org/618871/6839950'>Intuition in pharmacovigilance</a></li></ul>Join the conversation on social media Follow us on <a href='https://twitter.com/UMCGlobalSafety'>X</a>, <a href='https://www.linkedin.com/company/109057/'>LinkedIn</a>, or <a href='https://www.facebook.com/UppsalaMonitoringCentre'>Facebook</a> and share your thoughts about the show with the hashtag #DrugSafetyMatters. Got a story to share? We’re always looking for new content and interesting people to interview. If you have a great idea for a show, <a href='mailto:globalcomms@who-umc.org'>get in touch</a>! About UMC Read more about <a href='https://www.who-umc.org/'>Uppsala Monitoring Centre</a> and how we work to advance medicines safety.

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#28 Catching black swans – François Montastruc

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