Approval of first-generation devices, the ticagrelor controversy, ICD longevity, the PRAGUE-25 trial (one of the most important trials of the year), and some thoughts on the end of EP as a profession are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I More Ticagrelor Controversy <ul> <li>BMJ Investigation Finds More Concerns in Ticagrelor Trials https://www.medscape.com/viewarticle/investigation-bmj-raises-more-concerns-about-ticagrelor-2025a1000gh3</li> </ul> <ul> <li>Ticagrelor PLATO study https://www.bmj.com/content/389/bmj.r1201</li> <li>Ticagrelor vs Clopidogrel https://www.nejm.org/doi/full/10.1056/NEJMoa0904327</li> </ul> <ul> <li>Review of the Ticagrelor Trials Evidence Base https://www.ahajournals.org/doi/10.1161/JAHA.123.031606</li> <li>The Plato Trial: Do you believe in magic? https://doi.org/10.1093/eurheartj/ehp545</li> <li>ONSET/OFFSET Antiplatelet Effects https://www.ahajournals.org/doi/10.1161/circulationaha.109.912550</li> <li>RESPOND Study https://www.ahajournals.org/doi/10.1161/circulationaha.109.919456</li> </ul> II ICD Battery Longevity <ul> <li>Variability in ICD Battery Longevity https://doi.org/10.1016/j.hrthm.2025.05.031</li> </ul> PRAGUE-25 Trial of AF Ablation vs LFM <ul> <li>PRAGUE-25 Trial https://www.jacc.org/doi/10.1016/j.jacc.2025.04.042</li> </ul> You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

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Jul 11 2025 This Week in Cardiology

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