TWiM explores two different ways that bacteria defend against phages through the synthesis of cyclic nucleotides. Become a <a style="text-decoration: none;" href= "http://www.microbe.tv/contribute"> patron</a> of TWiM. Links for this episode: <ul style= "margin-top: 0px; margin-bottom: 0px; padding-inline-start: 48px;"> <li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"> Decoy cyclic nucleotides in <a style= "text-decoration: none;" href= "https://www.nature.com/articles/s41586-025-09557-z"> phage defense</a> (Nature) </li> <li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"> CRISPR defense with <a style="text-decoration: none;" href= "https://www.nature.com/articles/s41586-025-09569-9"> nucleotides</a> (Nature) </li> <li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"> A decoy defence molecule to set <a style= "text-decoration: none;" href= "https://pubmed.ncbi.nlm.nih.gov/41034659/"> a trap for viruses</a> (Nature) </li> <li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"> Cyclic oligonucleotide-based antiphage signaling system immunity (Curr Opin Immunol) </li> </ul> Music used on TWiM is composed and performed by <a style= "text-decoration: none;" href= "http://ronaldjenkees.com/"> Ronald Jenkees</a> and used with permission. Send your microbiology questions and comments to twim@microbe.tv

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343: Nucleotides to the Defense

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