Medicines can affect our personality in positive ways, but they may also lead to destructive behaviours that can damage our relationships, finances, and overall quality of life. Michele Fusaroli from the University of Bologna explains how to diagnose and treat drug-induced impulse control disorders.Tune in to find out:<ul><li>Which medicines may cause impulsivity</li><li>What the ‘four knights’ of impulsivity are</li><li>How patient stories can help detect these conditions</li></ul>Want to know more?<a href='https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.27668'>This review by Daniel Weintraub</a> summarises twenty years of research on impulse control disorders in Parkinson’s disease. In 2003, Driver-Dunckley and colleagues in the US published the <a href='https://www.neurology.org/doi/10.1212/01.WNL.0000076478.45005.EC'>first case series linking pathological gambling to dopamine agonists</a>. In 2016, the US Food and Drug Administration warned about <a href='https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-warns-about-new-impulse-control-problems-associated-mental-health'>impulse-control problems associated with the antipsychotic drug aripiprazole</a>. Michele and colleagues in Italy have investigated the <a href='https://onlinelibrary.wiley.com/doi/10.1111/pcn.13511'>mechanisms</a> and <a href='https://www.medrxiv.org/content/10.1101/2023.11.17.23298635v2'>burden</a> of drug-induced impulsivity. In their 2024 <a href='https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29700'>guidelines for managing impulsivity</a> in Parkinson's disease, an expert consensus group highlighted the pivotal role of caregivers and of psychosocial interventions. Finally, these are the Drug Safety Matters episodes cited in the interview:<ul><li><a href='https://www.drugsafetymatterspod.org/618871/14599616-28-catching-black-swans-francois-montastruc'>Catching black swans</a></li><li><a href='https://www.drugsafetymatterspod.org/618871/14405046-27-when-drugs-damage-the-liver-rita-baiao'>When drugs damage the liver</a></li><li><a href='https://www.drugsafetymatterspod.org/618871/13531660-uppsala-reports-long-reads-empowering-patients-as-partners'>Empowering patients as partners</a></li><li><a href='https://www.drugsafetymatterspod.org/618871/3844829-2-why-we-should-listen-to-patients-linda-harmark'>Why we should listen to patients</a></li></ul>Join the conversation on social media Follow us on <a href='https://twitter.com/UMCGlobalSafety'>X</a>, <a href='https://www.linkedin.com/company/109057/'>LinkedIn</a>, or <a href='https://www.facebook.com/UppsalaMonitoringCentre'>Facebook</a> and share your thoughts about the show with the hashtag #DrugSafetyMatters. Got a story to share? We’re always looking for new content and interesting people to interview. If you have a great idea for a show, <a href='mailto:comms@who-umc.org'>get in touch</a>! About UMC Read more about <a href='https://www.who-umc.org/'>Uppsala Monitoring Centre</a> and how we work to advance medicines safety.

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#29 When medicines change our behaviour – Michele Fusaroli

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