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This Week in Virology

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Vincent Racaniello

This Week in Virology is a netcast about viruses - the kind that make you sick.

#100

TWiV 1105: All the T and B in China

TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge. Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://turbidplaque.com/">Alan Dove</a>, <a title="" href= "https://mgm.ufl.edu/profile/condit-rich/">Rich Condit</a>, and <a title="" href= "https://medicine.umich.edu/dept/cmb/katherine-spindler-phd">Kathy Spindler</a> Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier (<a title="" href= "https://cupblog.org/2024/04/10/whats-the-difference-between-a-tree-and-a-building-sometimes-nothing-dickson-despommier/">blog post</a>) ---Navigating the U.S. Immigration System <a title="" href= "https://umich.zoom.us/webinar/register/WN_gVcTxT3xTBK2K_bpGQDZuQ">webinar</a> ---International Conferene on <a title="" href= "https://www.pathogen-ri.eu/conference/#overview">Pandemic Preparedness</a> ---Avian influenza in dairy cows <a href= "https://www.ncagr.gov/news/press-releases/2024/04/10/high-path-avian-influenza-detected-north-carolina-dairy-herd">North Carolina</a> and <a href= "https://news.sd.gov/news?id=news_kb_article_view&sys_id=8021b3f0876982906093bbf6cebb35a8">South Dakota</a> ---H5N1 clade 2.3.4.4 <a href= "https://www.biorxiv.org/content/10.1101/2024.04.04.588061v1">Pathogenic flu throughout NYC</a> ---Polio from <a href= "https://www.cidrap.umn.edu/measles/quick-takes-us-measles-cases-top-100-who-extends-polio-emergency">Afghanistan to Pakistan</a> extending public health emergency ---<a href= "https://www.cidrap.umn.edu/sexually-transmitted-infections/chatgpt-may-help-combat-vaccine-hesitancy-sexually-transmitted"> CHAT GPT</a> to combat vaccine hesitancy ---<a href= "https://www.who.int/news/item/09-04-2024-who-sounds-alarm-on-viral-hepatitis-infections-claiming-3500-lives-each-day"> Viral hepatitis</a> worldwide ---Dengue public health alert in <a href= "https://time.com/6960544/puerto-rico-public-health-emergency-dengue/">Puerto Rico</a> ---Cherry trees being <a href= "https://www.npr.org/2024/03/19/1238896379/cherry-blossom-trees-remove-stumpy-climate-change-washington-dc">drowned by water level rise</a> in DC ---Paul in <a title="" href= "https://www.npr.org/2024/03/13/1238251518/iron-lung-polio-paul-alexander">iron lung</a> dies (NPR) ---<a title="" href= "https://www.nature.com/articles/s41467-024-47358-6">Hepatitis B virus</a> in Eastern Eurasia (Nat Comm) ---<a title="" href= "https://www.nature.com/articles/s41590-024-01787-z">Antibody-independent protection</a> against heterologous SARS-CoV-2 (Nature) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Weekly Picks Brianne – <a href= "https://www.livescience.com/60037-do-other-planets-have-solar-eclipses.html">Do Other Planets Have Solar Eclipses?</a> Kathy – <a href= "https://wapo.st/4atET0V">Radcliffe Wave</a> and <a href= "https://www.nytimes.com/2024/04/09/world/europe/smoke-rings-italy-volcano.html?ugrp=c&unlocked_article_code=1.jk0.fOVe.H4v8zLt_pKta&smid=url-share">Mt. Etna smoke rings</a> with <a href= "https://www.nytimes.com/video/world/europe/100000009404942/smoke-rings-rise-from-mt-etna.html">video</a> Rich – Spongy Oak Apple Gall Wasp (Amphibolips confluenta) <a href= "http://www.minnesotaseasons.com/Insects/spongy_oak_apple_gall_wasp.html">Life cycle</a>; [Gall formation] (https://bygl.osu.edu/node/750) Alan – <a href= "https://www.justice.gov/opa/pr/montana-man-pleads-guilty-federal-wildlife-trafficking-charges-part-yearslong-effort-create">Rogue attempt to clone giant</a> sheep for captive hunting Vincent – <a title="" href= "https://www.nytimes.com/2024/04/09/style/pasteur-institute-music-bands.html?ugrp=c&unlocked_article_code=1.j00.33YS.MVPiy5ZgiPXN&smid=url-share">The Scientists Rock. Literally</a>. Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

14 Apr 2024

1 HR 57 MINS

1:57:39

14 Apr 2024

#99

TWiV 1104: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer’s phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how long COVID affects the brain and associates with an increase in allergic incidents as well as if post SARS-CoV-2 infected patients are unable to exercise or have functional limitations. For more information about this body of work, listen to <a title="" href= "https://www.microbe.tv/twiv/twiv-1088/">TWiV 1088</a>. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---Measles <a href= "https://www.cdc.gov/measles/cases-outbreaks.html">tracking</a> (CDC) ---Measles just <a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7314a1.htm?s_cid=mm7314a1_e&ACSTrackingID=USCDC_921-DM126221&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2073%2C%20April%2011%2C%202024&deliveryName=USCDC_921-DM126221">this year</a> (MMWR) ---ABRYSVO<a href= "https://www.pfizer.com/news/press-release/press-release-detail/pfizer-announces-positive-top-line-results-phase-3-study-1?cid=em_PfizerNewsroomAlert&ttype=em"> phase 3 results</a> (Pfizer) ---<a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html"> RSV</a> surveillance (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#maps_percent-covid-deaths"> Provisional deaths</a> due to COVID-19 (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC) ---<a href= "https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofae197/7641325"> Rural-urban differences</a> in COVID-19 mortality and hospitalizations (OFID) ---<a href= "https://www.cidrap.umn.edu/covid-19/cdc-advisers-recommend-spring-covid-booster-seniors"> Spring COVID-19 booster</a> recommendations (CIDRAP) ---<a href= "https://www.cdc.gov/media/releases/2024/s-0228-covid.html"> Older adult</a> spring booster available (CDC) ---<a href= "https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2024-02-28-29/06-COVID-Wallace-508.pdf"> Advisory committee for immunization practices</a> spring 2024 COVID-19 boosters (CDC) ---<a href= "https://www.fda.gov/news-events/press-announcements/fda-roundup-march-22-2024"> EUA for pemgarda</a> (FDA) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH) ---Nirmatrelvir for <a href= "https://www.nejm.org/doi/full/10.1056/NEJMoa2309003">vaccinated or unvaccinated</a> COVID-19 patients (NEJM) ---Assessment for <a href= "https://www.nejm.org/doi/abs/10.1056/NEJM198806303182605">clinical usefulness</a> (NEJM) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety) ---Updated <a href= "https://www.cdc.gov/ncird/whats-new/updated-respiratory-virus-guidance.html">respiratory virus</a> guidances (CDC) ---What do when your <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-%20assesment-hcp.html">heathcare provider </a>is infected with SARS-CoV-2 (CDC) ---Managing healthcare staffing <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html">shortages</a> (CDC) ---Steroids,<a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID) ---<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org) ---Long COVID evidence based review <a href= "https://www.microbe.tv/twiv/twiv-1088/">TWiV</a> shout out (TWiV 1088) ---<a href= "https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awae101/7638850?login=false"> Brian and cognitive changes</a> in long COVID patients (BRAIN) ---<a href= "https://www.nature.com/articles/s41467-024-47176-w">Allergic disease incidents</a> after COVID-19 (Nat Comm) ---Can post COVID patients <a href= "https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2817149">exercise</a> or do they have functional limitations (JAMA Network Open) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> 37:06 ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1102-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1092-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1100-letters/"> read</a> on TWiV 1102 37:56 ---Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+032224.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

13 Apr 2024

46 MINS

46:33

13 Apr 2024

#98

TWiV 1103: Jason 'Spike' McLellan

Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design. Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a> and <a title="" href= "https://mgm.ufl.edu/profile/condit-rich/">Rich Condit</a> Guest: <a title="" href= "https://molecularbiosci.utexas.edu/directory/jason-mclellan">Jason McLellan</a> Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier ---<a title="" href= "http://prefusion-stabilized%20sars-cov-2%20spikes/">Prefusion-stabilized</a> SARS-CoV-2 spikes (Science) ---Structure-based <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/35598506/">vaccine design</a> (Curr Opin Immunol) ---Prefusion-stabilized SARS-CoV-2 <a title="" href= "https://www.nature.com/articles/s41467-024-45404-x">S2-only antigen</a> (Nat Comm) ---Stabilized <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/34710354/">coronavirus spike stem</a> elicits broadly protective antibody (Cell Rep) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

07 Apr 2024

1 HR 05 MINS

1:05:24

07 Apr 2024

#97

TWiV 1102: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles and influenza before addressing Vincent’s comment on measles inclusion in the clinical respiratory PCR panel, the latest statistics on influenza and COVID-19 circulation, if inflammatory cytokines and anti-viral antibody function synergistically, if administration of peptide agonists of the glucagon-like or sodium-glucose pump can reduce disease severity, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines for SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir or paxlovid can reduce cardiovascular adverse events and the first finding of the two-year longitudinal study on long COVID. For more information about this body of work, listen to [TWiV 1088] (https://www.microbe.tv/twiv/twiv-1088/) . Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---Measles <a href= "https://www.cdc.gov/measles/cases-outbreaks.html">tracking</a> (CDC) ---What happens when measles is included in <a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7312a3.htm?s_cid=mm7312a3_e&ACSTrackingID=USCDC_921-DM125328&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2073%2C%20March%2028%2C%202024&deliveryName=USCDC_921-DM125328">commercial syndromic</a> PCR panels (MMWR) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a>(CDC) ---Influenza on the <a href= "https://www.statnews.com/2024/04/01/bird-flu-h5n1-spread-to-humans-dairy-cattle/">Texas ranch</a> (Statnews) ---Sequence analysis of highly pathogenic <a href= "https://www.cdc.gov/flu/avianflu/spotlights/2023-2024/h5n1-analysis-texas.htm">avian influenza from Texas</a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC) ---COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC) ---<a href= "https://www.ijidonline.com/article/S1201-9712(24)00087-0/fulltext"> Can inflammatory cytokines and antibodies</a> play nicely to prevent COVID-19 mortality (IJID) ---Association <a href= "https://link.springer.com/article/10.1007/s13300-024-01562-1">of GLP-1RA and SGLT-2i</a> to modulate COVID-19 severity (Diabetes Therapy) ---<a href= "https://www.cidrap.umn.edu/covid-19/cdc-advisers-recommend-spring-covid-booster-seniors"> Spring COVID-19 booster</a> recommendations (CIDRAP) ---<a href= "https://www.cdc.gov/media/releases/2024/s-0228-covid.html"> Older adult</a> spring booster available (CDC) ---<a href= "https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2024-02-28-29/06-COVID-Wallace-508.pdf"> Advisory committee for immunization practices</a> spring 2024 COVID-19 boosters (CDC) ---EUA for <a title="" href= "https://www.fda.gov/drugs/emergency-preparedness-drugs/emergency-use-authorizations-drugs-and-non-vaccine-biological-products">pemgarda</a> (FDA) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH) ---What do when your <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-%20assesment-hcp.html">heathcare provider </a>is infected with SARS-CoV-2 (CDC) ---Managing healthcare staffing <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html">shortages</a> (CDC) ---Steroids,<a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID) ---<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org) ---<a href= "https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciae170/7637630?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=40427954633&nbd_source=campaigner"> Remdesivir and cardiac adverse events</a> in hospitalized patients (CID) ---Long COVID evidence based review <a href= "https://www.microbe.tv/twiv/twiv-1088/">TWiV</a> shout out (TWiV 1088) ---Longitudinal study reveals <a href= "https://academic.oup.com/ofid/article/11/3/ofae027/7617262?utm_source=etoc&utm_campaign=ofid&utm_medium=email">long COVID symptom peaks and nadirs</a> (OFID) ---<a href= "https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03331-0"> Paxlovid lowers risk of cardiovascular disease</a> in COVID-19 patients with autoimmune disease (BMC Medicine) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1102-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1092-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1100-letters/"> read</a> on TWiV 1102 ---Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+032224.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

06 Apr 2024

49 MINS

49:30

06 Apr 2024

#96

TWiV 1101: It's not over 'til it's Offit

Paul Offit joins TWiV to discuss his latest book, “Tell Me When It’s Over”, an insider’s guide to deciphering COVID myths and navigating our post-pandemic world. Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://trichinella.org/">Dickson Despommier</a>, and <a title="Brianne Barker" href= "http://twitter.com/bioprofbarker">Brianne Barker</a> Guest: <a title="" href= "https://www.chop.edu/doctors/offit-paul-a">Paul Offit</a> Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier --- [Tell Me When It’s Over] (https://amzn.to/3J0ohSA) by Paul Offit ---<a title="" href= "https://umich.zoom.us/webinar/register/WN_gVcTxT3xTBK2K_bpGQDZuQ">Navigating the U.S. Immigration System</a> (webinar) ---<a title="" href= "https://www.bv-brc.org/docs/news/2024/2024-04-08-bv-brc-workshop-subspecies.html"> Classifying Viral Subspecies</a> (Workshop) ---<a title="" href= "https://www.optionsxii2024.org.uk/programme">Options XII for the Control of Influenza</a> (Meeting) ---<a title="Letters read" href= "https://www.microbe.tv/twiv/twiv-1101-letters/">Letters read</a> on TWiV 1101 ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Weekly Picks Dickson – <a title="" href= "https://eventhorizontelescope.org/blog/astronomers-unveil-strong-magnetic-fields-spiraling-edge-milky-way%E2%80%99s-central-black-hole">Astronomers Unveil Strong Magnetic Fields Spiraling at the Edge of Milky Way’s Central Black Hole</a> Brianne – <a title="" href= "https://www.scientificamerican.com/article/inside-the-ai-competition-that-decoded-an-ancient-scroll-and-changed/#:~:text=Building%20on%20the%20work%20each,them%20the%20%24700%2C000%20Grand%20Prize.">Inside the AI Competition That Decoded an Ancient Herculaneum Scroll</a> Vincent – <a href= "https://www.instagram.com/biotech.symposium?igsh=bWF0bzg1ZDdrNDUx">biotech.symposium</a> on Instagram Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

31 Mar 2024

1 HR 50 MINS

1:50:29

31 Mar 2024

#95

TWiV 1100: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles influenza and SARS-CoV-2, before discussing the development of new monoclonal antibody therapy, if vaccines and antivial drugs can used effectively together. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound including that after administration of the “oral remdesivir”, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if one can predict the loss infectivity of healthcare workers with mild COVID-19 disease and the dynamics of household transmission of the virus in children. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---Measles <a href= "https://www.cdc.gov/measles/cases-outbreaks.html">tracking</a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC) ---COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC) ---What new <a href= "https://www.fda.gov/news-events/press-announcements/fda-roundup-march-22-2024">monoclonal antibody</a> therapy? (FDA) ---A <a href= "https://investors.invivyd.com/news-releases/news-release-details/invivyd-announces-interim-exploratory-data-vyd222-ongoing-canopy/">New pre-exposure prophylaxis</a> for COVID-19? (Invivyd) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH) ---<a href= "https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2816033"> Really COVID-19 rebound</a> after Nirmatrelvir-ritonavir treatment? (JAMA Network Open) ---<a href= "https://www.ijidonline.com/article/S1201-9712(24)00083-3/fulltext"> Can vaccines and antiviral be effective</a> for COVID-19 together (International Journal of Infectious Diseases) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH) ---What do when your <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-%20assesment-hcp.html">heathcare provider </a>is infected with SARS-CoV-2 (CDC) ---Managing healthcare staffing <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html">shortages</a> (CDC) ---<a href= "https://academic.oup.com/cid/article/78/3/613/7262516?utm_source=etoc&utm_campaign=cid&utm_medium=%20email&nbd=13518097993&nbd_source=campaigner"> Can loss of infectivity</a> among healthcare works with mild and recurrent COVID-19 be predicted (CID) ---<a href= "https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciae069/7634443"> Household transmission dynamics</a> in children with asymptomatic infection (CID) ---Steroids,<a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID)<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19">Anticoagulation</a> guidelines (hematology.org) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1092-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1100-letters/"> read</a> on TWiV 1098 ---Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+032224.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

30 Mar 2024

44 MINS

44:18

30 Mar 2024

#94

TWiV 1099: Volker Lohmann, as persistent as his viruses

Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus. Host: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a> Guests: <a title="" href= "https://www.klinikum.uni-heidelberg.de/zentrum-fuer-infektiologie/molecular-virology/about-us/research-teams/ag-lohmann">Volker Lohmann</a> Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier ---HCV <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/37742699/">human challenge</a> studies (Lancet Gastro Hepatol) ---Comparison of <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/37121436/">HCV and HAV</a> infections (J Hepatol) ---HCV <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/24164647/">cell culture </a>systems (J Med Chem) Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

24 Mar 2024

1 HR 12 MINS

1:12:31

24 Mar 2024

#93

TWiV 1098: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---Measles <a href= "https://www.cdc.gov/measles/cases-outbreaks.html">tracking</a> (CDC) ---Measles in <a href= "https://www.cdc.gov/measles/cases-outbreaks.html">Cook County</a> (MMWR) ---<a href= "https://www.infectiousdiseaseadvisor.com/home/general-infectious-disease/measles-surge-due-to-gaps-in-routine-%20vaccination-following-covid19-pandemic/"> Gaps in measles vaccination</a> drives viral surges (Infectious Disease Advisor) ---<a href= "https://www.idsociety.org/multimedia/videos/idsa-media-briefing-measles-and-misinformation-the-impact-on-public-%20health/#xd_co_f=OTBhOWYzNTktYzQwMS00MzExLWEyZTEtM2I0NWQwMjJhMWYy~"> Misinformation impacts</a> public health? Seriously? (ID Society) ---CDC alert for <a href= "https://emergency.cdc.gov/han/2024/han00504.asp">global and domestic</a> measles cases and outbreaks (CDC) ---<a href= "https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.11.2400106"> Mpox</a> in Kamituga associated with outbreak in DRB (Eurosurviellance) ---<a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7215a5.htm#:~:text=Discussion,1%2C000%20mpox%20cases%20occurred%20worldwide.&text=Nearly%20all%20U.S.%20mpox%20decedents%20were%20immunocompromised%20at%20the%20time%20of%20diagnosis"> Mpox in US</a>, 2023 (MMWR) ---<a href= "https://reliefweb.int/report/democratic-republic-congo/la-variole-simienne-monkeypox-en-republique-democratique-du-congo-rapport-de-la-situation-epidemiologique-sitrep-no003-du-19-25-fevrier-2024?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp"> Mpox in DRC</a>, 2024 (reliefweb) ---CDC guidance for <a href= "https://www.idsociety.org/globalassets/idsa/multimedia/clinician-call-slides--qa/3-14-2024-clinician-call.pdf">respiratory diseases, COVID antiviral & emergence of clade I mpox</a> (ID Society) ---<a href= "https://www.cidrap.umn.edu/mpox/more-600-dead-spreading-dr-congo-mpox-outbreak-republic-congo-reports-its-first-cases"> ~5% of infected</a> dead from mpox (CIDRAP) ---<a href= "https://apnews.com/article/congo-mpox-epidemic-outbreak-disease-7c72b0efda36703155689377263d5899"> First cases of mpox</a> in Republic of Congo (AP News) ---Respiratory <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a> (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC) ---COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7310a2.htm">Multisystem inflammatory</a> syndrome in children 2023 (MMWR) ---Guidance for COVID-19 in <a href= "https://academic.oup.com/jpids/advance-%20article/doi/10.1093/jpids/piad116/7604963?utm_source=etoc&utm_campaign=jpids&utm_medium=email">children and adolescents</a> (JPIDS) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH) ---What do when your <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-%20assesment-hcp.html">heathcare provider </a>is infected with SARS-CoV-2 (CDC) ---Managing healthcare staffing <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html">shortages</a> (CDC) ---Steroids,<a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID) ---<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org) ---<a href= "https://jamanetwork.com/journals/jama/fullarticle/2816676">High/low oxygenation target</a> (JAMA) ---<a href= "https://jamanetwork.com/journals/jama/fullarticle/2816679"> How much oxygen</a> is needed (JAMA) ---<a href= "https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.29486"> Orthostatic intolerance</a> in long COVID and healthy volunteers (JMV) ---<a href= "https://link.springer.com/article/10.1007/s00431-024-05503-9"> Autonomic cardiac function</a> in children and adolescents with long COVID (European Journal of Pediatrics) ---Long COVID <a href= "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10907301/%20https:/www.cam.ac.uk/research/news/low-iron-%20levels-resulting-from-infection-could-be-key-trigger-of-long-covid">iron dysregulation and inflammatory stress</a> erythropoiesis (Nat Imm) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1092-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1098-letters/"> read</a> on TWiV 1098 ---Dr. Griffin's COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+032224.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

23 Mar 2024

48 MINS

48:58

23 Mar 2024

#92

TWiV 1097: Tiny cells and giant viruses in a castle

Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes. Host: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a> Guests: <a title="" href= "https://scholar.google.com/citations?user=LdTiI-EAAAAJ&hl=en">Sheree Yau</a> and <a title="" href= "https://en.uit.no/nyheter/forskerhjornet/827829/the_arctic_giant_from_tromso">Victoria Queiroz</a> Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier 8:16 ---<a title="" href= "https://pubmed.ncbi.nlm.nih.gov/21444812/">Virophage control</a> of antarctic algal host-virus dynamics (PNAS) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! ---<a title="" href= "https://pubmed.ncbi.nlm.nih.gov/32270031/">Virus-host coexistence in phytoplankton</a> through the genomic lens (Sci Adv) ---Two groups of <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/37395647/">pithoviruses</a> (J Virol) ---<a title="" href= "https://pubmed.ncbi.nlm.nih.gov/32005257/">Educational toolkit</a> for virology classes (J Virol) Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

17 Mar 2024

57 MINS

57:26

17 Mar 2024

#91

TWiV 1096: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, how COVID-19 effects the autonomic nervous system, and if nirmatrelvir-ritonavir protects against adverse cardiovascular effects following SARS-CoV-2 infection. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---<a href= "https://www.cdc.gov/measles/cases-outbreaks.html">Measles everywhere</a> (CDC) ---Respiratory <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a> (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC) ---Estimating <a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7309a4.htm?s_cid=mm7309a4_e&ACSTrackingID=USCDC_9%2021-%20DM124001&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2073%2C%20March%207%20%2C%202024&deliveryName=USCDC_921-DM124001">niresevimab</a> effectiveness for infants (MMWR) ---<a href= "https://www.nbcnews.com/health/health-news/kids-died-flu-2024-healthy-cdc-vaccination-rcna134963"> More than 100 children died</a> of influenza (NBS News) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC) ---COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC) ---Did the <a href= "https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2023-064446/196419/Vaccine-Effectiveness-%20Against-Long-COVID-in?autologincheck=redirected">vaccine protect children</a> against Long COVID (Pediatrics) ---<a href= "https://www.nature.com/articles/s41467-024-46497-0">Did</a> COVID-19 vaccination impact cardiovascular diseases? (Nat Comm) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety) ---Updated <a href= "https://www.cdc.gov/ncird/whats-new/updated-respiratory-virus-guidance.html">respiratory infection</a> guidelines (CDC) ---What do when your <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-%20assesment-hcp.html">heathcare provider </a>is infected with SARS-CoV-2 (CDC) ---Managing healthcare staffing <a href= "https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html">shortages</a> (CDC) ---Steroids,<a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID) ---<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org) ---Long COVID trial for <a href= "https://www.nih.gov/news-events/news-releases/nih-opens-long-covid-trials-evaluate-treatments-autonomic-%20nervous-system-dysfunction">autonomic nervous system</a> dysfunction (NIH) ---<a href= "https://link.springer.com/article/10.1007/s10557-024-07570-4"> Nirmatrelvir-ritonavir </a>impact on myocardial injury and long-term cardiovascular outcomes in COVID-19 hospitalized patients (Cardiovascular Drugs and Therapy) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1092-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1096-letters/"> read</a> on TWiV 1096 ---Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+12-21-2023.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

16 Mar 2024

41 MINS

41:25

16 Mar 2024

#90

TWiV 1095: Monkeys fly and mice exaggerate

TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy. Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://trichinella.org/">Dickson Despommier</a>, [Alan Dove] (http://turbidplaque.com/) , [Rich Condit] (https://mgm.ufl.edu/profile/condit-rich/) , and Angela Mingarelli Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier ---<a title="" href= "https://wwwnc.cdc.gov/eid/article/30/1/23-1164_article">Heterosexual transmission</a> of clade I Mpox virus (Emerg Inf Dis) ---<a title="" href= "https://www.paho.org/en/documents/epidemiological-update-oropouche-region-americas-6-march-2024"> Continued circulation</a> of oropouche virus (PAHO and WHO) ---Herpesviruses in <a title="" href= "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0299404">fur seals and sea lions</a> (PLoS One) ---<a title="" href= "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0292203"> Sex-specific effects</a> of SARS-CoV-2 infection (PLoS One) ---Drivers of 2022 <a title="" href= "https://www.cell.com/action/showPdf?pii=S0092-8674%2824%2900124-7">Mpox virus epidemic</a> (Cell) ---How <a title="" href= "https://youtu.be/CMFUbSfUEYk?si=n1lDMO3orug_tHsI">AAV gene</a> transfer works (YouTube) ---Humanized mouse model for <a title="" href= "https://www.nature.com/articles/s41467-024-46017-0">AAV gene therapy</a> (Nat Comm) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Weekly Picks Dickson – <a title="" href= "https://youtu.be/HgR7YJpOoPE?si=MCQMQU5ZfCI_87Nk">Baden Powell – Manha de Carneval</a> Angela – Upcoming Health & Fitness podcast from MicrobeTV Rich – <a href= "https://msmithphotos.com/">Mark Smith Photography</a> Alan – <a href= "https://www.floridamuseum.ufl.edu/overt/">OpenVertebrate</a> (and [Science article] (https://www.science.org/content/article/check-out-some-most-unusual-exhibits-digital-cabinet-curiosities) on it) Vincent – <a href= "https://totalvetnerds.com/">Veterinary apparel for the veterinary nerd</a> Listener Pick Anne – <a title="" href= "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vVk1QMTY4NDcxNTg5Mw/episode/NTM5MDUwOGMtNWQ2MC0xMWVlLTg0ZDctZmY3NjkyM2M0Njg4?sa=X&ved=0CAYQkfYCahcKEwioxs-xsuKEAxUAAAAAHQAAAAAQAQ">Why Reed Jobs is betting on cancer innovations</a> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

10 Mar 2024

1 HR 45 MINS

1:45:54

10 Mar 2024

#89

TWiV 1094: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermectin as an antiviral drug, when to use steroids and the benefits of convalescent plasma, how COVID-19 affects cognitive function and the effect of long COVID and how healthcare works have difficulty making the proper diagnosis for long COVID even using a questionnaire. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---Respiratory <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a> (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC) ---COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC) ---What to <a href= "https://www.cdc.gov/ncird/whats-new/updated-respiratory-virus-guidance.html">do when you are sick</a> with a respiratory virus (CDC) ---Basis for respiratory virus <a href= "https://www.cdc.gov/respiratory-viruses/background/index.html">guidance</a> (CDC) ---Effectiveness of <a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">updated COVID-19 vaccines (MMWR)</a> ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---<a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a5.htm">NIH</a> COVID-19 treatment guidelines (NIH) ---<a href= "https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciae105/7614681"> Synergy or additive protection</a> with vaccination and oral antivirals (CID) ---To rebound or to <a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a1.htm?s_cid=mm7251a1_e&ACSTrackingID=USCDC_921-DM119319&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2072%2C%20December%2022%2C%202023&deliveryName=USCDC_921-DM119319">not rebound</a> (MMWR) ---<a href= "https://esmed.org/MRA/mra/article/view/3041">Know your</a> COVID-19 tools (ESMED) --- [How to pay] (https://www.paxlovid.com/paxcess) for Paxlovid (PAXCESS) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---<a href= "https://www.journalofinfection.com/article/S0163-4453(24)00064-1/fulltext"> Still talking about Ivermectin</a>? (Journal of Infection) ---Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety) ---Steroids,<a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID) ---<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org) ---<a href= "https://www.nejm.org/doi/full/10.1056/NEJMoa2311330">Cognition and memory</a> after COVID-19 (NEJM) ---<a href= "https://www.cidrap.umn.edu/covid-19/even-fully-recovered-survivors-mild-covid-can-lose-iq-points-study-suggests"> Loss of IQ</a> after SARS-CoV-2 infection (CIDRAP) ---<a href= "https://www.nejm.org/doi/full/10.1056/NEJMe2400189">Really, more evidence</a> for long COVID and impaired cognition (NEJM) ---Memory assessment <a href= "https://www.nejm.org/doi/full/10.1056/NEJMc2311200?query=infectious-%20disease&cid=DM2328422_Non_Subscriber&bid=2135121174">before and after</a> COVID-19 (NEJM) ---Please complete this <a href= "https://communityhyperbaric.com/wp-content/uploads/2020/04/Everyday-Memory-Questionnaire-EMQ.pdf">memory questionnaire</a> (Community hyperbaric) ---Impact of <a href= "https://www.microbe.tv/twiv/turning%20to%20social%20media%20groups%20for%20support,%20validation,%20and%20information.%20https:/journals.plos.org/plosone/article?id=10.1371/journal.pone.0299743">long-term COVID-19</a> on workers in healthcare settings (PLoS One) ---Healthcare workers have <a href= "https://www.cidrap.umn.edu/covid-19/even-healthcare-workers-face-difficulty-accessing-long-covid-care-review-suggests">difficulty assessing</a> long COVID (CIDRAP) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1092-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1094-letters/"> read</a> on TWiV 1094 ---Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+12-21-2023.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

09 Mar 2024

53 MINS

53:00

09 Mar 2024

#88

TWiV 1093: Reservoir bats and jumbo phage

TWiV discusses effectiveness of this season’s flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery. Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "https://mgm.ufl.edu/profile/condit-rich/">Rich Condit</a>, <a title="" href= "https://medicine.umich.edu/dept/microbiology-immunology/katherine-r-spindler-phd">Kathy Spindler</a>, <a title="" href= "http://twitter.com/bioprofbarker">Brianne Barker,</a> and <a title="" href= "http://ramseylab.vercel.app/">Jolene Ramsey</a> Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier ---Effectiveness of flu vaccine (<a title="" href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7308a3.htm">MMWR</a>, <a title="" href= "https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.8.2300239">Eurosurveill</a>) ---Efficacy of <a title="" href= "https://www.pfizer.com/news/press-release/press-release-detail/pfizer-announces-positive-top-line-data-full-season-two">Pfizer RSV vaccine</a> (Pfizer) ---Understanding <a href= "https://www.pfizer.com/news/articles/understanding_six_types_of_vaccine_technologies">six types of vaccine technologies</a> (Pfizer) ---<a title="" href= "https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2024-02-28-29/02-POLIO-Kidd-508.pdf"> nOPV in US?</a> (CDC) ---<a title="" href= "https://www.gob.pe/institucion/minsa/noticias/911809-gobierno-aprueba-declaracion-de-emergencia-sanitaria-a-20-regiones-por-un-plazo-de-90-dias-debido-al-incremento-del-dengue"> Dengue</a> in Peru (Peruvian State) ---Measles in <a title="" href= "https://www.michigan.gov/mdhhs/inside-mdhhs/newsroom/2024/02/23/measles">Michigan</a> and <a title="" href= "https://www.cidrap.umn.edu/measles/indiana-reports-first-measles-case-5-years">Indiana</a> ---Marburg virus control by reservoir bats (Nat Commun) ---<a title="" href= "https://www.sciencedirect.com/science/article/pii/S2405471221002052"> tRNA acquisition</a> by phages (Cell) --- [Viruses of Microbes 2024] (https://www.vom2024.org/) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Weekly Picks Brianne – <a href= "https://www.washingtonpost.com/nation/2024/03/01/death-valley-lake-california-rain/">The reappearance of Lake Manly</a> Kathy – <a href= "https://centerforhealthsecurity.org/sites/default/files/2024-02/24-02-14-cdc-misinfo-playbook_0.pdf">“Practical Playbook for Addressing Health Misinformation”</a> Rich – <a href= "https://www.amazon.com/Making-So-Memoir-Patrick-Stewart/dp/1982167734/ref=sr_1_1?crid=1PN1UNY23S57J&dib=eyJ2IjoiMSJ9.IPRAgxyB0q0tnJafkRchfaG_12TOr7kMEoil5UDnrgJU0IDZcG9PHoQ5dNMSRvNvgg33aqAPaqpUsCkaSw7eAbc8OnPCspB8etfAvipJ3mHliD3DRh2ap9rKDhqbo6DJn68wvIzQ8dEot4H9WSgRXxQKY6HB35s1JvYkE35h1sY3sHIfUn-RogQxVe3jVbXT6_rXT8TOTlT47yniX72nd1Hah7gkEYcpnGL3B1VdvvU.5fUuSf-CLs31PjkhJLFTdt2SGarABiPtgELkzmnlFdU&dib_tag=se&keywords=making+it+so+patrick+stewart&qid=1709309467&s=books&sprefix=making+it+so%2Cstripbooks%2C200&sr=1-1">Making It So: A Memoir by Patrick Stewart</a> Jolene – <a href= "https://www.amazon.com/Thinking-Like-Phage-Viruses-Bacteria/dp/0990494314/">Thinking Like a Phage</a> by Merry Youle Vincent – <a href= "https://airandspace.si.edu/stories/editorial/science-leap-year">The Science of Leap Year</a> Listener Picks Blog design – <a title="" href= "https://apnews.com/article/anthony-fauci-memoir-june-on-call-c1a5ffac822ab31e791a63f69ccfd61d">Anthony Fauci will reflect on his long government career in ‘On Call,’ to be published in June</a> Peter – <a title="" href= "https://www.rawstory.com/scott-cepicky/">Republican warns of vaccines being slipped into vegetables: ‘A polio vaccine in there’</a> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

03 Mar 2024

1 HR 55 MINS

1:55:50

03 Mar 2024

#87

TWiV 1092: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---Respiratory <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a> (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC) ---RSV <a href= "https://www.cidrap.umn.edu/avian-influenza-bird-flu/quick-takes-good-uptake-rsv-vaccines-moms-and-infants-%20first-avian-flu-wv">vaccination stats</a> (CIDRAP) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC) ---COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC) ---ACIP <a href= "https://www.cidrap.umn.edu/covid-19/cdc-advisers-recommend-spring-covid-booster-seniors">COVID vaccination for seniors</a> recommendations (CIDRAP) ---Additional vaccine doses for <a href= "https://www.cdc.gov/media/releases/2024/s-0228-covid.html">older adults</a> (CDC) ---<a href= "https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2024-02-28-29/06-COVID-Wallace-508.pdf"> Evidence based advice</a> from the ACIP (CDC) ---State mandates <a href= "https://www.pnas.org/doi/abs/10.1073/pnas.2313610121">did NOT</a> influence primary vaccination rates only boosters (PNAS) ---<a href= "https://www.cdc.gov/vaccines/acip/meetings/downloads/agenda-archive/agenda-2024-02-28-29-508.pdf"> No nOPV2</a>? (CDC) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---To rebound or to <a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a1.htm?s_cid=mm7251a1_e&ACSTrackingID=USCDC_921-DM119319&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2072%2C%20December%2022%2C%202023&deliveryName=USCDC_921-DM119319">not rebound</a> (MMWR) ---<a href= "https://esmed.org/MRA/mra/article/view/3041">Know your</a> COVID-19 tools (ESMED) --- [How to pay] (https://www.paxlovid.com/paxcess) for Paxlovid (PAXCESS) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---<a href= "https://www.nature.com/articles/s41467-024-45641-0">Molunpiravir plus antibody therapy</a> for at-risk outpatients (Nat Comm) ---Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety) ---Steroids, <a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID) ---<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org) ---<a href= "https://www.science.org/doi/10.1126/sciadv.adi9379">Spontaneous release</a> of IFN-g in Long COVID (Science Advances) ---<a href= "https://www.nature.com/articles/s41593-024-01576-9">Blood-brain-barrier compromise</a> in long COVID associated cognitive impairment (Nat Neuroscience) ---<a href= "https://www.nature.com/articles/s41586-024-07029-4">Persistent community</a> SARS-CoV-2 RNA (Nature) ---<a href= "https://www.nature.com/articles/s41598-022-15565-0">Hyberbaric oxygen therapy</a> improves post COVID neurocognition (Scientific Reports) ---Medical study questionnaire, <a href= "https://www.brandeis.edu/roybal/docs/SF-36_website_PDF.pdf">the SHORT form</a> (Brandeis) ---<a href= "https://www.nature.com/articles/s41598-024-53091-3">Long term effects</a> of hyperbaric oxygen post COVID (Scientific Reports) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1092-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/"> read</a> on TWiV 1092 ---Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+12-21-2023.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

02 Mar 2024

56 MINS

56:20

02 Mar 2024

#86

TWiV 1091: Skeeter poo and obelisks too

TWiV reviews resurgence of Lassa fever in West Africa, at least 3 paralytic cases of cVDPV2 in Zimbabwe, CWD from eating prion-laden plants, measles in New Orleans and Broward County Florida, failure of Florida Surgeon General to support vaccination, a measles variant in Switzerland, SARS-CoV-2 persistent infections, leaky blood-brain-barrier for long COVID brain fog, West Nile virus transmitted among mosquitoes by the excreta, and viroid-like colonists of human microbiomes. Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://trichinella.org/">Dickson Despommier</a>, [Alan Dove] (http://www.turbidplaque.com/) , [Rich Condit] (https://mgm.ufl.edu/profile/condit-rich/) and <a title="" href= "https://medicine.umich.edu/dept/microbiology-immunology/katherine-r-spindler-phd"> Kathy Spindler</a> Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) ---Research assistant position in Rosenfeld Lab CBER/FDA (<a href= "https://twiv.s3.amazonaws.com/Research+Assistant.pdf">pdf</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier --- [Viruses of Microbes 2024] (https://www.vom2024.org/) ---Resurgence of <a title="" href= "https://www.science.org/content/article/deadly-viral-illness-exploding-west-africa-researchers-are-scrambling-figure-out-why">Lassa fever </a>(Science) ---<a title="" href= "https://www.unicef.org/media/152321/file/Zimbabwe-Polio-Response-SitRep-16-February-2024.pdf"> cVDPV2</a> in Zimbabwe (UNICEF) ---CWD from <a title="" href= "https://www.cidrap.umn.edu/chronic-wasting-disease/plants-can-take-cwd-causing-prions-soil-lab-what-happens-if-they-are-eaten">eating plants</a> (CIDRAP) ---<a title="" href= "https://ldh.la.gov/news/7268">Measles</a> in New Orleans (LA Dept Health) ---SARS-CoV-2 <a title="" href= "https://www.nature.com/articles/s41586-024-07029-4">persistent infections</a> (Nature) ---Leaky BBB for <a title="" href= "https://www.nature.com/articles/s41593-024-01576-9">brain fog of long COVID</a> (Nat Neurosci) ---<a title="" href= "https://wsvn.com/news/local/broward/students-return-to-manatee-bay-elementary-following-6-confirmed-cases-of-measles/"> Measles</a> in Broward County FL (7 News) ---Failure of FL Surgeon General to <a title="" href= "https://twitter.com/han_francis/status/1760129416707911886">support vaccination</a> (X) ---Measles <a title="" href= "https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.5.2400034#html_fulltext">variant</a> (Eurosurveillance) ---West Nile virus <a title="" href= "https://www.biorxiv.org/content/10.1101/2024.01.29.577888v1.full">transmitted among mosquitos</a> by excreta (bioRxiv) ---Mosquito <a title="" href= "https://www.youtube.com/watch?v=EUrOcquy8IU">life cycle</a> (YouTube) ---<a title="" href= "https://www.biorxiv.org/content/10.1101/2024.01.20.576352v1">Viroid-like colonists</a> of human microbiomes (bioRxiv) ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1091-letters/">Letters read</a> on TWiV 1091 ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Weekly Picks Dickson – <a title="" href= "https://bcse.org/market-trends/">Sustainable energy in America 2024 factbook</a> Kathy – <a href= "https://store.usps.com/store/product/buy-stamps/life-magnified-stamps-S_484004">Life Magnified USPS stamps</a> Rich – “ [How plants communicate with each other when in danger] (https://wapo.st/3I9SrCl) ” by Kasha Patel (<a href= "https://www.nature.com/articles/s41467-023-41589-9#Sec2">Original Nature Communications article</a>) Alan – <a href= "https://thousandyearoldvampire.com/products/a-sargasso-sea-of-space-party-card-game">A Sargasso Sea of Space</a> card game. Vincent – <a href= "https://amzn.to/3I8U5nV">Tell Me When It’s Over</a> by Paul Offit Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

25 Feb 2024

1 HR 49 MINS

1:49:05

25 Feb 2024

#85

TWiV 1090: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus before discussing uptake of the RSV vaccine Abrysvo or the monoclonal anti-RSV antibody nirsevimab to prevent severe disease following RSV infection in infants 8 months or younger before going over this week’s influenza virus and SARS-CoV-2 virus statistics, including all circulating variants in the US, examines if self-testing is more accurate than clinician administered Binax rapid diagnostic tests for SARS-CoV-2 infection, if N95 masks need a yearly fitting, how SARS-CoV-2 vaccination impacts the prevalence of long COVID, reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, why determining the exact number of long COVID incidences is challenging, how the incidence and predictors for fatiguing illness following SARS-CoV-2 infection may used to reenforce the need for public health actions to prevent virus infection and the risks of respiratory pathologies including lung cancer associate with SARS-C0V-2 infection. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---Respiratory <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a> (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC) ---RSV <a href= "https://www.cidrap.umn.edu/avian-influenza-bird-flu/quick-takes-good-uptake-rsv-vaccines-moms-and-infants-%20first-avian-flu-wv">vaccination stats</a> (CIDRAP) ---<a href= "https://www.axios.com/2024/02/20/rsv-vaccine-children-%20protection?utm_campaign=editorial&utm_medium=social&utm_source=twitter"> Abrysvo</a> vaccine stats (Axios) ---RSV vaccination <a href= "https://www.cdc.gov/vaccines/imz-managers/coverage/rsvvaxview/index.html">dashboard</a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC) ---COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC) ---Who is more accurate the <a href= "https://journals.asm.org/doi/10.1128/spectrum.02525-23">clinician or the self</a> for BinaxNow rapid testing (ASM Spectrum) ---Annual N95<a href= "https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/annual-n95-%20respirator-fittesting-an-unnecessary-burden-on-%20healthcare/EFB7AE65A2473AD4EC0EA0CE641AE015?utm_source=SFMC&utm_medium=email&utm_cont%20ent=Article&utm_campaign=New%20Cambridge%20Alert%20-%20%20Issues&WT.mc_id=New%20Cambridge%20Alert%20-%20Issues"> fitting</a> (Infection Control and Hospital Epidemiology) ---<a href= "https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/annual-n95-%20respirator-fittesting-an-unnecessary-burden-on-%20healthcare/EFB7AE65A2473AD4EC0EA0CE641AE015?utm_source=SFMC&utm_medium=email&utm_cont%20ent=Article&utm_campaign=New%20Cambridge%20Alert%20-%20%20Issues&WT.mc_id=New%20Cambridge%20Alert%20-%20Issues"> How vaccination impacts</a> long COVID prevalence (Annals of Epidemiology) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---To rebound or to <a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a1.htm?s_cid=mm7251a1_e&ACSTrackingID=USCDC_921-DM119319&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2072%2C%20December%2022%2C%202023&deliveryName=USCDC_921-DM119319">not rebound</a> (MMWR) ---<a href= "https://esmed.org/MRA/mra/article/view/3041">Know your</a> COVID-19 tools (ESMED) --- [How to pay] (https://www.paxlovid.com/paxcess) for Paxlovid (PAXCESS) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety) ---Steroids, <a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID) ---<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org) ---Long COVID <a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7306a4.htm?s_cid=mm7306a4_w">in adults</a> (MMWR) ---<a href= "https://wwwnc.cdc.gov/eid/article/30/3/23-1194_article">Estimating and predicting</a> fatiguing illness after SARS-CoV-2 infection (EIS) ---<a href= "https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00079-8/fulltext"> Long term risks</a> of respiratory disease following SARS-CoV-2 infection (eClinical Medicine) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letter</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1090-letters/">s</a><a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/"> read</a> on TWiV 1080 ---Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+12-21-2023.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

24 Feb 2024

35 MINS

35:52

24 Feb 2024

#84

TWiV 1089: Shoot out at the Circle-T ranch

TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells. Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://trichinella.org/">Dickson Despommier</a>, [Alan Dove] (http://www.turbidplaque.com/) , and <a title="" href= "http://twitter.com/bioprofbarker">Brianne Barker</a> Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) ---Research assistant position in Rosenfeld Lab CBER/FDA (<a href= "https://twiv.s3.amazonaws.com/Research+Assistant.pdf">pdf</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier --- [Viruses of Microbes 2024] (https://www.vom2024.org/) ---Fatal case of <a title="" href= "https://alaskabeacon.com/2024/02/09/first-fatal-case-of-alaskapox-a-newly-identified-viral-disease-claims-kenai-peninsula-man/">Alaskapox</a> (AK Beacon) ---<a title="" href= "https://wwwnc.cdc.gov/eid/article/30/3/23-1488_article">MERS</a> in Kenya (Emerg Inf Dis) ---Diagnostic tests for <a title="" href= "https://cepi.net/news_cepi/testing-the-tests-scientists-seek-out-best-on-the-spot-diagnostics-for-deadly-nipah-and-lassa/">Nipah and Lassa</a> (CEPI) ---Measles in <a title="" href= "https://www.maricopa.gov/CivicAlerts.aspx?AID=2871">Arizona</a> and <a title="" href= "https://www.cbsnews.com/minnesota/news/health-officials-confirm-measles-case-in-twin-cities-metro/">Minnesota</a> ---HCV-derived <a title="" href= "https://pubmed.ncbi.nlm.nih.gov/38319965/">circular RNAs</a> (PNAS) ---<a title="" href= "https://www.nature.com/articles/s41586-023-06937-1">Resident memory CD8 T cells</a> prevent respiratory virus transmission (Nature) ---<a href= "https://www.microbe.tv/twiv/twiv-1089-letters/">Letters read</a> on TWiV 1089 1:24:33 ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Weekly Picks Dickson – <a title="" href= "https://blogs.scientificamerican.com/sa-visual/visualizing-science-illustration-and-beyond/">Visualizing Science: Illustration and Beyond</a> Brianne – <a href= "https://themisinformationvirus.com/">Vaccination from the Misinformation Virus</a> and <a href= "https://invisiblecorps.com/">Invisible Corps</a> Alan – <a href= "https://www.npr.org/sections/health-shots/2024/02/13/1230448059/shots-needles-phobia-vaccines-pain-fear-kids">Preventing needlephobia in kids</a> Vincent – Two new Djs I discovered <a href= "https://www.youtube.com/@rosananun4298">Rosana Nun</a> and <a href= "https://www.youtube.com/@sunsetcartel_dbn/videos">Sunset Cartel</a> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

18 Feb 2024

1 HR 49 MINS

1:49:37

18 Feb 2024

#83

TWiV 1088: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the use of monoclonal antibody therapy to prevent RSV hospitalization of infants and use of GSK’s RSV vaccine Arexy to prevent severe disease following RSV infection in adults between 50-59 years before he reviews recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if how the influenza vaccine is manufactured can reprogram the antibody response, cardiovascular consequences of influenza infection, mortality of chikungunya virus infection, if an alternative vaccination schedule impacts the anti-SARS-CoV-2 immune response, dispels the myth that increased mortality correlated with the first vaccine dose, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how manage long COVID including prevent burnout and compassion fatigue of caring for long COVID patients, whether the CDC or WHO definition of long COVID is beneficial or the use of directed questions, baselines test and listening to the patient tell their story are beneficial in making a long COVID diagnosis. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---<a href= "https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.6.2400046"> Nirsevimab</a> immunoprophylaxis to prevent RSV hospitalization (Eurosurveillance.) ---<a href= "https://www.gsk.com/en-gb/media/press-releases/arexvy-accepted-under-priority-review-in-us-for-the-%2520prevention-of-rsv-disease-in-adults-aged-50-59-at-increased-risk/"> Arexvy</a> given Priority Review in US for the prevention of RSV disease in adults aged 50-59 (GSK) ---Respiratory <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a> (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC) ---<a href= "https://www.nature.com/articles/s41467-023-44551-x">Can antibodies be redirected</a> from egg adapted epitopes using recombinant or cell cultured based influenza vaccines (Nat) ---Can influenza <a href= "https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae070/7603794">infection lead to</a> cardiovascular events (JID) ---<a href= "https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00739-%25209/fulltext?dgcid=raven_jbs_aip_email"> Risk of death after chikungunya infection</a> and disease (Lancet) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a>(CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map </a>(CDC) ---COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions">Variant</a> tracker (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC) ---<a href= "https://www.nature.com/articles/s41467-024-45334-8">Alternative intervals</a> between vaccine doses (Nat Comm) ---<a href= "https://academic.oup.com/cid/advance-%2520article/doi/10.1093/cid/ciad604/7595862?utm_source=advanceaccess&utm_campaign=cid&utm_medium=emai%2520l&nbd=40427954633&nbd_source=campaigner"> Early mortality</a> after first vaccination dose (CID) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---To rebound or to <a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a1.htm?s_cid=mm7251a1_e&ACSTrackingID=USCDC_921-DM119319&ACSTrackingLabel=This%2520Week%2520in%2520MMWR:%2520Vol.%252072,%2520December%252022,%25202023&deliveryName=USCDC_921-DM119319">not rebound</a> (MMWR) --- [Know your] (https://esmed.org/MRA/mra/article/view/3041) COVID-19 tools (ESMED) --- [How to pay] (https://www.paxlovid.com/paxcess) for Paxlovid (PAXCESS) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---Convalescent plasma recommendation for immunocompromised (IDSociety) ---Steroids, <a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID) ---<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org) ---<a href= "https://academic.oup.com/ofid/advance-%2520article/doi/10.1093/ofid/ofae080/7603019?utm_source=advanceaccess&utm_campaign=ofid&utm_medium=e%2520mail&nbd=40427954633&nbd_source=campaigner"> Burnout compassion</a> fatigue Long COVID (OFID) ---<a href= "https://jamanetwork.com/journals/jama/fullarticle/2805540">Scoring</a> PASC (JAMA) ---What is <a href= "https://www.who.int/europe/news-room/fact-sheets/item/post-covid-19-condition">your definition</a> of the Long COVID (WHO) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1088-letters/">Letters read</a> on TWiV 1088 ---Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+12-21-2023.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

17 Feb 2024

58 MINS

58:46

17 Feb 2024

#82

TWiV 1087: Should old infections be forgot

TWiV reviews rhinovirus complications in infants, a new influenza antiviral drug, Oropouche fever in Brazil, measles in Maryland and Ohio, effect of eliminating non-medical vaccine exemptions in NY, foot-and-mouth disease in Europe, severe primary and secondary dengue infections, and therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections. Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://trichinella.org/">Dickson Despommier</a>, [Rich Condit] (https://mgm.ufl.edu/profile/condit-rich/) , and Angela Mingarelli Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode --- [MicrobeTV Discord Server] (https://discord.gg/xA4JX7AeeU) ---MicrobeTV store at <a title="" href= "http://cafepress.com/twiv">Cafepress</a> ---Become a member of ASV (<a title="" href= "http://asv.org/">asv.org</a>) ---Research assistant position in Rosenfeld Lab CBER/FDA (<a href= "https://twiv.s3.amazonaws.com/Research+Assistant.pdf">pdf</a>) --- [The New City] (http://www.despommier.com/) by Dickson Despommier --- [Viruses of Microbes 2024] (https://www.vom2024.org/) ---Infant <a title="" href= "https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2814626">rhinovirus bronchiolitis contribution</a> to hospital bed and vent use (JAMA Net Open) ---Onradivir new <a title="" href= "https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00743-0/fulltext">influenza antiviral</a> (Lancet) ---<a title="" href= "https://www.paho.org/en/documents/epidemiological-alert-oropouche-region-americas-2-february-2024"> Oropouche fever</a> in Brazil (PAHO) ---<a title="" href= "https://health.maryland.gov/newsroom/Pages/One-Case-of-Measles-Confirmed-in-Maryland-Resident-with-Recent-International-Travel.aspx"> Maryland</a> and <a title="" href= "https://odh.ohio.gov/media-center/odh-news-releases/odh-news-release-02-03-24">Ohio</a> measles ---Repealing school <a title="" href= "https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2814630">vaccination exemptions</a> (JAMA New Open) ---Increases risk of <a title="" href= "https://www.pig333.com/latest_swine_news/increased-risk-of-foot-and-mouth-disease-entry-into-europe_20042/">FMDV entry</a> into Europe (pig333) ---Severe primary and secondary <a title="" href= "https://www.nature.com/articles/s41591-024-02798-x">dengue</a> (Nat Med) ---Mitigation of <a title="" href= "https://www.nature.com/articles/s41467-024-45418-5">measles immune amnesia</a> and exacerbated disease (Nat Comm) ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1087-letters/">Letters read</a> on TWiV 1087 ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Weekly Picks Dickson – <a title="" href= "https://science.nasa.gov/get-involved/citizen-science/for-your-processing-pleasure-the-sharpest-pictures-of-jupiters-volcanic-moon-io-in-a-generation/">For Your Processing Pleasure: The Sharpest Pictures of Jupiter’s Volcanic Moon Io in a Generation</a> Angela – <a href= "https://whalescientists.com/">Whale Scientists</a> Rich – <a href= "https://www.sciencedirect.com/science/article/pii/S0264410X23008721">Benefit-risk assessment of vaccines</a>; <a href= "https://www.sciencedirect.com/science/article/pii/S0264410X2301109X#:~:text=In%20August%202021%2C%20the%20Brighton,from%20different%20platforms%2C%20based%20on">The Brighton collaboration standardized module for vaccine benefit-risk assessment</a>; <a href= "https://www.sciencedirect.com/science/article/pii/S0140673605784233?via%3Dihub">Vaccine adverse events: causal or coincidental?</a>; <a href= "https://acappellatexas.org/singing-valentines/">Austin area Singing Valentines</a> Vincent – <a href= "https://www.un.org/en/observances/women-and-girls-in-science-day">International Day of Women and Girls in Science, 11 February</a> Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv ... Read more

11 Feb 2024

1 HR 51 MINS

1:51:55

11 Feb 2024

#81

TWiV 1086: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market and why people conceal their infectious diseases before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if susceptibility and disease severity are inheritable traits, if vaccination during pregnancy protects neonates or leads to adverse effects, the effectiveness of a monovalent XBB.1.5 against disease resulting from infection with Omicron variants, whether vaccination in the same or opposite arms effect antibody protection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how SARS-CoV-2 infection may alter one’s sleep patterns, what the health and economic burdens of mild disease are, and if there are predictors for recovery from fatigue and cognitive deficits following SARS-CoV-2 infection. Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"> Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, [email] (http://eepurl.com/Gcw59) Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV! Links for this episode ---Do you <a href= "https://jamanetwork.com/journals/jama-health-forum/fullarticle/2814360%20https:/www.cidrap.umn.edu/covid-19/pandemic-resulted-high-healthcare-worker-turnover">want a job in</a> healthcare? (JAMA) ---Why people <a href= "https://journals.sagepub.com/doi/abs/10.1177/09567976231221990">don’t tell the truth</a> about infectious diseases (Psychological Science) ---Respiratory <a href= "https://www.cdc.gov/surveillance/nrevss/index.html">disease</a> surveillance (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/index.html">surveillance</a> (CDC) ---RSV <a href= "https://www.cdc.gov/surveillance/nrevss/rsv/natl-trend.html">national</a> trend (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/index.htm">surveillance </a> (CDC) ---Influenza/flu <a href= "https://www.cdc.gov/flu/weekly/usmap.htm">map</a> (CDC) ---COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00">hospital</a> admissions (CDC) ---COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html">national</a> trend (CDC) ---COVID-19 <a href= "https://biobot.io/data/">wastewater</a> testing (biobot) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions"> Variant</a> tracker (CDC) ---<a href= "https://covid.cdc.gov/covid-data-tracker/#trends_weeklyhospitaladmissions_select_00"> Variant hospital</a> admissions (CDC) ---Is <a href= "https://www.nature.com/articles/s41467-023-44250-7">susceptibility and severity</a> of COVID-19 inheritabile (Nat Comm) ---<a href= "https://jamanetwork.com/journals/jama/fullarticle/2814537"> Neonates</a> of vaccinated mothers (JAMA) ---How is the <a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7304a2.htm?s_cid=mm7304a2_e&ACSTrackingID=USCDC_921-DM121333&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2073%2C%20February%201%2C%202024&deliveryName=USCDC_921-DM121333">monovalent XBB.1.5 vaccine</a> effectiveness against symptomatic infection Sept 2023-Jan 2024 (MMWR) ---Second dose in the <a href= "https://www.jci.org/articles/view/176411">opposite arm</a> improves antibody response (JCI) ---Virus specific <a href= "https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00308-0/fulltext">immune repsonses</a> following contralateral or ipsilateral immunication (eBioMedicine) ---<a href= "https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html"> CDC Quarantine</a> guidelines (CDC) ---To rebound or to <a href= "https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a1.htm?s_cid=mm7251a1_e&ACSTrackingID=USCDC_921-DM119319&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2072%2C%20December%2022%2C%202023&deliveryName=USCDC_921-DM119319">not rebound</a> (MMWR) ---<a href= "https://esmed.org/MRA/mra/article/view/3041">Know your</a> COVID-19 tools (ESMED) --- [How to pay] (https://www.paxlovid.com/paxcess) for Paxlovid (PAXCESS) ---Molnupiravir <a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011">safety</a> and efficacy (JMV) ---Convalescent plasma recommendation for <a href= "file:///Users/Amy/Desktop/">immunocompromised</a> (IDSociety) ---Steroids,<a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978">dexamethasone</a> at the right time (OFID) ---<a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"> Anticoagulation</a> guidelines (hematology.org) ---How COVID-19 <a href= "https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1281012/full">affected your sleep</a> (Frontiers in Public Health) ---<a href= "https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03235-5"> Health and economic burden</a> of COVID-19 after illness (BMC Medicine) ---<a href= "https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00035-X/fulltext"> Predicting recovery</a> from fatigue and cognitive deficits after COVID-19 (eClinical Medicine) ---Contribute to our <a href= "https://parasiteswithoutborders.com/">ASTMH fundraiser at PWB</a> ---<a title="" href= "https://www.microbe.tv/twiv/twiv-1086-letters/">Letters read</a> on TWiV 1086 ---Dr. Griffin’s COVID treatment summary (<a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+12-21-2023.pdf">pdf</a>) ---Timestamps by <a href= "https://ramseylab.vercel.app/">Jolene</a>. Thanks! Intro music is by <a href= "http://www.ronaldjenkees.com/">Ronald Jenkees</a> Send your questions for Dr. Griffin to daniel@microbe.tv ... Read more

10 Feb 2024

43 MINS

43:14

10 Feb 2024

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