<blockquote>“Your genes are not your destiny.”</blockquote><blockquote>David Sinclair, PhD</blockquote>Aging is inevitable. Everybody grows old. Everyone dies.We accept these statements as fact.But what if they're just stories based on history and our current understanding of biology?What if everything we think we know about aging is about to change?Across the globe, scientists are working on treatments and therapies that are designed to extend healthy human lifespans well beyond what we know today.At the bleeding edge of such breakthroughs you will find&nbsp;David Sinclair, PhD,&nbsp;one of the world’s leading scientific authorities on longevity, aging and how to slow its effects.Returning for his second appearance on the podcast, David is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher&nbsp;at M.I.T. where, among other things, he co-discovered the cause of aging for yeast.The co-founder of several biotechnology companies, David is also co-founder and co-chief editor of the journal&nbsp;Aging. His work has been featured in a variety of books, documentaries, and media, including&nbsp;60 Minutes, Nightline&nbsp;and&nbsp;NOVA. He is an inventor on 35 patents, has been lauded as one of the&nbsp;Top 100 Australian Innovators, and made&nbsp;TIME&nbsp;magazine’s list of the&nbsp;100 most influential people in&nbsp;the world.In addition, David is the author of&nbsp;Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To&nbsp;-- a&nbsp;New York Times bestseller that&nbsp;proposes a radical new theory of aging. As he writes: “Aging is a disease, and that disease is treatable.”<a href="https://www.http://bit.ly/richroll498A" target="_blank"><img src="https://www.richroll.com/wp-content/uploads/podcast/DavidSinclair_498_quote_910x512-copy.jpg"></a>Last year I convened my first conversation with David (<a href="https://www.richroll.com/podcast/david-sinclair-436/" target="_blank">RRP #436</a>), a scintillating and science-heavy primer on all things human lifespan, aging and longevity. It was a runaway hit with the listeners -- and left me wanting to know more.So today we pick up where we last left off, diving deeper into the physiological mechanisms that contribute to biological degeneration. And we&nbsp;go further into the current state of research to better understand what contributes to aging and what can be done to counteract it.Call him a dreamer, but David believes living to 200+ is a plausible reality. If you could double your lifespan, how would this impact how you choose to live? What would it mean for the future of humanity? And for the ecological stability of the planet? The implications are profound.Equal parts philosophic and scientific, this conversation will forever change&nbsp;the way you think about why you age and what you can do about it. And it will leave you armed simple lifestyle practices you can deploy -- intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat -- that will help you live younger and healthier for longer.Brilliant and lovely, it’s an honor to once again share this man's wisdom with you today. So break out that pen and paper, because you're going to want to take notes on this one.The visually inclined can watch it all go down on&nbsp;<a href="http://bit.ly/davidsinclair498" target="_blank">YouTube</a>.&nbsp;And as always, the audio version streams wild and free on&nbsp;<a href="http://bit.ly/rrpitunes" target="_blank">Apple Podcasts</a>&nbsp;and&nbsp;<a href="http://bit.ly/rrpspotify" target="_blank">Spotify.</a>I sincerely hope you enjoy the episode.Peace + Plants,<img src="http://www.richroll.com/wp-content/uploads/2014/11/RR-SIGNATURE-FOR-WEB-1101.png">Listen, Watch &amp; Subscribe<a href="http://bit.ly/rrpitunes" target="_blank"><img src="http://www.richroll.com/wp-content/uploads/podcast/Listen-on-Apple-Podcasts-badge-e1526004054435.jpg"></a>&nbsp;&nbsp;&nbsp;<a href="http://youtube.com/richroll" target="_blank"><img src="http://www.richroll.com/wp-content/uploads/podcast/YT-logo-e1526003355103.png"></a>&nbsp;&nbsp;&nbsp;<a href="http://bit.ly/rrpspotify" target="_blank"><img src="http://www.richroll.com/wp-content/uploads/podcast/SPOTIFY-LOGO.png"></a>&nbsp;&nbsp;&nbsp;<a href="http://bit.ly/rrpgoogle" target="_blank"><img src="http://www.richroll.com/wp-content/uploads/podcast/Google-Podcasts-Header-1080x750.png"></a>&nbsp;&nbsp;&nbsp;&nbsp;<a href="http://bit.ly/rrpstitcher" target="_blank"><img src="http://www.richroll.com/wp-content/uploads/podcast/STITCHER-NEW-LOGO1.png"></a><a href="http://bit.ly/rrpitunes" target="_blank">Apple Podcasts</a>&nbsp;|&nbsp;<a href="http://youtube.com/richroll" target="_blank">YouTube</a>&nbsp;|&nbsp;<a href="http://bit.ly/rrpspotify" target="_blank">Spotify</a>&nbsp;|&nbsp;<a href="http://bit.ly/rrpstitcher" target="_blank">Stitcher</a>&nbsp;|&nbsp;<a href="http://bit.ly/rrpgoogle" target="_blank">Google Podcasts</a>Thanks to this week’s sponsorsOn Running:&nbsp;Born in the Swiss Alps,&nbsp;On Running is the world's fastest growing running brand. From their patented cushioning system to their gorgeous minimal design aesthetic, On has become my got to for all my trail and road running needs with gear that fits, performs and looks great. To learn more about On go to&nbsp;<a href="http://www.on-running.com/richroll" target="_blank">on-running.com/richroll</a>, pick your favorite shoe or apparel piece, and run in it for 30 days after which you can keep ‘em or return ‘em for a full refund no questions asked - an amazing no risk deal.Squarespace:&nbsp;The easiest way to create a beautiful website, blog, or online store for you and your ideas.&nbsp;Save 10%&nbsp;at checkout&nbsp;when visit&nbsp;<a href="https://www.squarespace.com/richroll" target="_blank">squarespace.com/richroll</a>&nbsp;and use the offer code&nbsp;RICHROLL&nbsp;at checkout.Zip Recruiter:&nbsp;Search for jobs hiring in your area using ZipRecruiter’s job search engine – the best way to find a job. To find jobs hiring near you and apply with just 1 click, visit:&nbsp;<a href="https://www.ziprecruiter.com/richroll" target="_blank">ziprecruiter.com/richroll</a>Note:&nbsp;One of the best ways to support the podcast is to support the sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes,&nbsp;<a href="http://www.richroll.com/resources/" target="_blank">visit my Resources page and click "Sponsors".</a>SHOW NOTESCheck out David's NYT bestseller:&nbsp;<a href="https://www.amazon.com/gp/product/1501191977/ref=as_li_qf_asin_il_tl?ie=UTF8&amp;tag=ricroloffweb-20&amp;creative=9325&amp;linkCode=as2&amp;creativeASIN=1501191977&amp;linkId=8ea96c523b2cd4a3ca2b0dc44650d195" target="_blank">Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To*</a><ul><li>Connect With David:&nbsp;<a href="https://lifespanbook.com" target="_blank">Website</a>&nbsp;|&nbsp;<a href="https://www.facebook.com/davidsinclairphd/" target="_blank">Facebook</a>&nbsp;|&nbsp;<a href="https://twitter.com/davidasinclair/" target="_blank">Twitter</a>&nbsp;|&nbsp;<a href="https://www.instagram.com/davidsinclairphd/" target="_blank">Instagram</a>&nbsp;|&nbsp;<a href="https://www.linkedin.com/in/sinclairda" target="_blank">LinkedIn</a></li><li>Life Biosciences:&nbsp;<a href="http://lifebiosciences.com/about-us/" target="_blank">Life Biosciences</a></li><li>Podcast Notes:&nbsp;<a href="https://podcastnotes.org/2019/04/22/sinclair-2/" target="_blank">David Sinclair on The Rich Roll Podcast</a></li><li>Harvard Medical School:&nbsp;<a href="https://genetics.med.harvard.edu/sinclair/" target="_blank">The Sinclair Lab</a></li><li>Harvard Medical School:&nbsp;<a href="https://hms.harvard.edu/news/rewinding-clock" target="_blank">Rewinding The Clock</a></li><li>Harvard Magazine:&nbsp;<a href="https://www.harvardmagazine.com/2017/09/anti-aging-breakthrough" target="_blank">Anti-Aging Approaches: David Sinclair's anti-aging science</a></li><li>TIME Magazine:&nbsp;<a href="http://time.com/5159879/is-an-anti-aging-pill-on-the-horizon/" target="_blank">Is an Anti-Aging Pill on the Horizon?</a></li><li>TIME Magazine:&nbsp;<a href="http://time.com/5209427/aging-nicotinamide-mononucleotide-nmn/" target="_blank">This Compound Can Reverse Aging in Mice. Will It Work in People?</a></li><li>Longevity Facts:&nbsp;<a href="http://longevityfacts.com/harvard-professor-dr-david-sinclair-nmn-nad-reverses-vascular-aging/" target="_blank">NMN and NAD Reverse Aging of Blood Vessels in New Study</a></li><li>Inside Tracker:&nbsp;<a href="http://blog.insidetracker.com/david-sinclair-harvard-anti-aging-success" target="_blank">Q&amp;A: How Harvard's David Sinclair Unlocked His Own Fountain of Youth</a></li><li>Slate:&nbsp;<a href="https://www.nextbigfuture.com/2019/02/anti-aging-researcher-david-sinclair-takes-metformin-nmn-nad-for-longevity.html" target="_blank">Could A Pill Slow Aging? Geneticist David Sinclair Thinks So</a></li><li>Next big Future:&nbsp;<a href="https://www.nextbigfuture.com/2019/02/anti-aging-researcher-david-sinclair-takes-metformin-nmn-nad-for-longevity.html" target="_blank">Anti-Aging Researcher David Sinclair Takes Metformin, NMN, NAD for Longevity</a></li><li>YouTube: (VIDEO)&nbsp;<a href="https://www.youtube.com/watch?v=9bhDgBhRgtk" target="_blank">David Sinclair Slowing down Aging</a>&nbsp;| My NMN Journey</li><li>TedMed: (VIDEO)&nbsp;<a href="https://www.tedmed.com/talks/show?id=7149" target="_blank">"Can a pill a day help keep aging away?"</a>&nbsp;| David Sinclair, PhD</li><li>Book:&nbsp;<a href="https://www.amazon.com/gp/product/0525444467/ref=as_li_qf_asin_il_tl?ie=UTF8&amp;tag=ricroloffweb-20&amp;creative=9325&amp;linkCode=as2&amp;creativeASIN=0525444467&amp;linkId=e8ce40e1e02aaa466fdd6d3482c14177" target="_blank">Now We Are Six (Winnie-the-Pooh)</a>* by A.A. Milne</li><li>Supplement:&nbsp;<a href="https://www.amazon.com/gp/product/B01LWYNYAU/ref=as_li_qf_asin_il_tl?ie=UTF8&amp;tag=ricroloffweb-20&amp;creative=9325&amp;linkCode=as2&amp;creativeASIN=B01LWYNYAU&amp;linkId=bd7befeb7dcc13350febe8f8f94ab994" target="_blank">M98 Micronized Resveratrol by Revgenetics</a>*</li></ul>Related Podcasts You Might Enjoy:<ul><li><a href="https://www.richroll.com/podcast/david-sinclair-436/" target="_blank">RRP #436: David Sinclair On Extending Human Lifespan</a></li><li><a href="https://www.richroll.com/podcast/valter-longo-367/" target="_blank">RRP #367: Fasting For Longevity With Valter Longo, Ph.D.</a></li><li><a href="https://www.richroll.com/podcast/danbuettner/" target="_blank">RRP #139: How To Live To Be 100+ With Dan Buettner</a></li><li><a href="https://www.richroll.com/podcast/rhonda-patrick/" target="_blank">RRP #209: Rhonda Patrick, PhD On Longevity, Epigenetics &amp; Microbiome Health</a></li></ul>Thanks to&nbsp;<a href="http://www.jasoncamiolo.com/" target="_blank">Jason Camiolo</a>&nbsp;for production, audio engineering and show notes; Margo Lubin and&nbsp;<a href="https://www.blakecurtis.net/" target="_blank">Blake Curtis</a>&nbsp;for video, editing and graphics; portraits by&nbsp;<a href="http://pranalens.com" target="_blank">Ali Rogers;</a>&nbsp;and theme music by&nbsp;<a href="https://soundcloud.com/user-981033703" target="_blank">Ana Leimma</a>.*Disclosure:&nbsp;Books and products denoted with an asterisk are hyperlinked to an affiliate program.&nbsp;We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.<a href="http://meals.richroll.com" target="_blank"><img src="https://www.richroll.com/wp-content/uploads/podcast/PLANTPOWER-MEAL-PLANNER-BANNER-6001.jpg"></a><a href="http://meals.richroll.com" target="_blank">for 1000s of delicious, customized plant-based recipes &amp; so much more, check out our Plantpower Meal Planner</a>HOW&nbsp;CAN I SUPPORT THE PODCAST?Tell Your Friends &amp; Share Online!Subscribe &amp; Review:&nbsp;&nbsp;<a href="https://itunes.apple.com/us/podcast/the-rich-roll-podcast/id582272991?mt=2" target="_blank">iTunes</a>&nbsp;|&nbsp;<a href="http://bit.ly/rrpspotify" target="_blank">Spotify</a>&nbsp;|&nbsp;<a href="http://www.stitcher.com/podcast/30437" target="_blank">Stitcher</a>&nbsp;|&nbsp;<a href="https://soundcloud.com/richroll" target="_blank">Soundcloud</a>&nbsp;|&nbsp;<a href="https://play.google.com/music/m/Ik2a22yi44ypcky7h6vnjvran4e?t=The_Rich_Roll_Podcast" target="_blank">Google Podcasts</a>Donate:&nbsp;Check out our&nbsp;<a href="https://www.patreon.com/richroll" target="_blank">Patreon account</a>Support The Sponsors:&nbsp;One of the best ways to support the podcast is to support our sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes,&nbsp;<a href="http://www.richroll.com/resources/" target="_blank">visit my Resources page and click "Sponsors".</a><blockquote> </blockquote>

Podurama

Home

Trending

Personal

Your Podcasts

New Episodes

My Files

Favourite Episodes

Tags (Folders)

Recently Played

Bookmarks

Followed Playlists

Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Aging

Rich Roll