In this episode:00:46 A virtual chemical library uncovers potential antidepressantsCertain psychedelic drugs are of interest to researchers due to their promising antidepressant effects.&nbsp;To help speed up the discovery of molecules with useful properties, researchers have built a virtual library of 75 million compounds related to these drugs. This approach yielded two molecules that showed antidepressant properties in mice, but without the hallucinogenic activity of psychedelic drugs.Research article: <a href="https://www.nature.com/articles/s41586-022-05258-z#?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank">Kaplan et al.</a>Research Briefing: <a href="https://www.nature.com/articles/d41586-022-03020-z#?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank">Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity</a>08:25 Research HighlightsResearch suggests that ancient artificial island settlements were hubs of activity for society’s elite, and astronomers spot possibly the most luminous star ever observed.Research Highlight: <a href="https://www.nature.com/articles/d41586-022-03053-4#?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank">Ancient DNA suggests that artificial islands were party spots for the elite</a>Research Highlight: <a href="https://www.nature.com/articles/d41586-022-03054-3#?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank">Scientists face down ‘Godzilla’, the most luminous star known</a>10:42 Nobel NewsFlora Graham from the Nature Briefing joins us to talk about the winners of this year’s Nobel Prizes.Nature News: <a href="https://www.nature.com/articles/d41586-022-03086-9#?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank">Geneticist who unmasked lives of ancient humans wins medicine Nobel</a>Nature News: <a href="https://www.nature.com/articles/d41586-022-03088-7#?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank">‘Spooky’ quantum-entanglement experiments win physics Nobel</a>Nature News: <a href="https://www.nature.com/articles/d41586-022-03087-8#?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank">Chemists who invented revolutionary 'click' reactions win Nobel</a><a href="https://www.nature.com/articles/d41586-022-03114-8#?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank">Enter Nature’s ‘Scientist at Work’ photo competition, full details here</a><a href="#" rel="noopener noreferrer" target="_blank">Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.</a><hr> Hosted on Acast. See <a style='color:grey;' target='_blank' rel='noopener noreferrer' href='https://acast.com/privacy'>acast.com/privacy</a> for more information.

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Virtual library of LSD-like drugs could reveal new antidepressants

Nature Podcast